Topical medicines are the first-line treatment for most skin conditions. Effective use of topical medicines requires their transport and crossing the epidermal barrier. For this purpose, various methods of drug delivery to the skin are used: introduction of components that change the structure of the stratum corneum of the epidermis or introduction of special transport systems into their formulation. Currently, different types of lipid transport systems are most commonly used for transdermal drug transfer. Among them, microemulsions should be highlighted as a universal carrier of active ingredients of drugs. Virtually all types of drugs, including both lipophilic and hydrophilic substances, can be transferred transdermally using a microemulsion. The use of these transport systems provides increased bioavailability of poorly soluble substances, their rapid penetration into the skin, as well as the cost-effectiveness of the final product. Topical corticosteroids are one of the most commonly used medications in dermatology. They have long been widely used in clinical practice; nevertheless, their formulations and composition continue to improve. An example would be an ointment containing 0.1% micronized methylprednisolone aceponate. The introduction of the proprietary base into the formulation allows for the presence of methylprednisolone aceponate in the form of microparticles, which further optimizes the bioavailability, and efficacy/safety ratio.