The study of the new coronavirus infection COVID-2019 caused by SARS-CoV-2 continues around the world. As an acute respiratory viral infection, SARS-CoV-2 (and earlier SARS-CoV) has a special pathogenic potential, the basis of the various pathological manifestations including nonspecific lesion of the vessels of the microvasculature. We present our own clinical observations describing the course of COVID-2019 accompanied by hemorrhagic angiitis with manifestations on the skin both at the onset of the disease and after clinical and virological cure. Modern scientific knowledge in the field of immunology, pathophysiology, clinical medicine makes it possible to assume the leading role in the pathogenesis of the infectious process caused by SARS-CoV-2, endothelial dysfunction involving the implementation of morphofunctional disorders of the system of adhesive molecules of endothelial cells, platelets and immunocytes. It is proposed to interpret skin angiitis in such patients as a complication with the formulation «virus-associated angiitis». The presented clinical material demonstrates the obvious commonality of the mechanisms of angiitis development that is a morphological substrate of organ lesions including skin, in COVID-2019 the absence of an autoimmune component that is confirmed by the effectiveness of low doses of systemic glucocorticosteroids. The issues of pathogenesis and pharmacological correction of vascular, immunological disorders and coagulopathy using SARS-CoV-2 as an example require further study that requires the involvement of a wide range of researchers to study and discuss the hypothesis put forward.