According to the current regulatory documents for the management of patients with syphilis, children who received treatment for early congenital syphilis are under clinical and serological control for 3 years. Later on, in the absence of indications for further observation or additional treatment, they are excluded from the observation, dissolved in the population, and their subsequent fate remains unknown, in any case, to the dermatovenerologists who treated them. A coincidence allowed the authors of this article to be acquainted with the health problems of three adult young people (two girls and one young man), whom they consulted and treated in the neonatal period for early congenital syphilis. The clinical forms of early congenital syphilis in all three patients were different: in two patients it was manifest and in one patient it was latent. The latent variant of congenital syphilis left virtually no consequences: a 20-year-old woman sought counseling during pregnancy, had a negative nontreponemal test, she was not given preventive treatment in accordance with current recommendations and she gave birth to a healthy baby on time. The situation was worse for the 18-year-old boy: he was diagnosed only at the age of 2 months and then treatment was prescribed. Despite 3 full-fledged additional courses over the next few years the nontreponemal test remained positive which suggests the possibility of developing late lesions of the internal organs and nervous system. The most serious consequences were the 23-year-old girl who had clinical manifestations not only on the skin, mucous membranes and internal organs, but also on the nervous system (meningitis) during the neonatal period. In childhood during the growth period there were learning difficulties, behavioral instability, treatment by a psychiatrist and psychologist, at present there is depression, memory impairment, poor sleep; treatment by a psychiatrist.