Relevance. Microbial associations with fungal components in chronic recurrent infected dermatoses can worsen their course, causing and maintaining skin inflammation. In cases of clinical practice, when it is necessary to use a combination therapy, the dermato-venerologist faces the question of prescribing the most effective topical drug with the maximum therapeutic effect on the infected focus.

OBJECTIVE

To study the fungicidal activity of combined preparations for external therapy in the treatment of chronic recurrent infected dermatoses.

MATERIAL AND METHODS

An experimental study of the fungicidal activity of external drugs recommended for the treatment of patients with HRD was carried out by the agar diffusion method. Reference strains were used as test microorganisms: Candida albicans, Trichophyton rubrum, Aspergillus niger, Penicillium chrisogenum, Fusarium oxysporum, Rhizopus nigricans, Alternaria alternata. The size of the growth retardation zone around the ring was used to judge the antifungal effect of substances.

RESULTS

Analysis of the fungicidal activity of combined preparations for external use showed that a cream containing betamethasone dipropionate, clotrimazole and gentamicin sulfate has an antifungal effect against the genera of Candida, Penicillium, Fusarium, Rhizopus, Alternaria. The cream containing oxytetracycline hydrochloride and hydrocortisone did not show fungicidal activity. However, it showed a pronounced fungistatic activity on the active growth and formation of reproductive structures of fungi of the genus Alternaria and Rhizopus. It was also an inducer of pigment formation in Fusarium fungi.

Summary. An external preparation containing betamethasone dipropionate, clotrimazole, and gentamicin sulfate had an antifungal effect against fungi that most often caused exacerbations of CRID.