ACTUALIZATION

The program of saturating aging skin with the necessary substances is one of the leading places in injection cosmetology.

OBJECTIVE

Evaluation of morphological changes in the skin upon intradermal administration of a preparation containing a germanium-organic chelate complex with succinic acid using histological and immunohistochemical research methods.

MATERIALS AND METHODS

The course of intradermal injections of the drug was administered to 20 volunteers (12 women, 8 men, mean age 55 years). The implants of the preparation were injected using the multi-puncture technique into the skin behind the ear area 4 times with an interval of 14 days. All volunteers at 5 stages of observation (before the start of the course, after 2 procedures, 2 weeks after 4 procedures, 2.5 months after 4 procedures, 5.5 months after the start of the procedures), a skin biopsy was performed in the injection zone, followed by histological and immunohistochemical examination.

RESULTS

With intradermal injection of the drug in the skin of volunteers, an increase in the formation of type I and III collagen and neutral mucopolysaccharides, as well as an increase in neoangiogenesis in the dermis, was detected.

CONCLUSION

The use of a preparation containing an organic germanium chelate complex with succinic acid leads to dermal restructuring, which, in turn, helps to strengthen the skin frame and prevent aging processes.