Certain chronic dermatoses such as atopic dermatitis and eczema are often complicated by various secondary infection (bacterial and/or mycotic). This is caused by impaired barrier function of the skin due to intense itching and reduced immune response. Inadequate care for inflamed skin is also risk factor of secondary infection. Staphylococcus aureus, Candida albicans and other microorganisms are the most common causative agent of infection. Diagnosis of this complication is relatively clear while therapy requires adequate selection of the drug. Combined drugs containing glucocorticosteroids, antibacterial and antimycotic components should be first-line medicines in these clinical cases. Medical records of patients with complicated atopic dermatitis and eczema confirm the effectiveness of the drug consisting of mometasone furoate, gentamicin, econazole, and dexapanthenol. Administration of combined medicines for dermatosis complicated by secondary infection allows you to accelerate regression of skin lesion and remission onset.