The article provides a literature review and clinical presentation of rare precancerous disease, Gottron’s cutaneous carcinoid papillomatosis. This rare disease is characterized by pseudoepitheliomatous hyperplasia of the epidermis. Histogenesis of the disease in not fully understood. Histological examination shows pseudoepitheliomatous hyperplasia of the epidermis. Etiology and pathogenesis of the disease are insufficiently studied. Mechanical trauma, chronic inflammation with long-existing dermatoses, as well as circulatory disorders and acroasphyxia, and predisposition of the organism to papillomatous reactions play an important role in the development of the disease. The article presents three cases of the disease. Development of the disease was associated with vascular pathology of the lower extremities in two patients and with post-surgical scars in one patients.