Changes in the epidermal barrier are observed for dermatoses accompanied by dry skin and impaired desquamation of keratinocytes. Increased evaporation of water through the epidermis stratum corneum is known to facilitate dehydration and development of skin dryness (xerosis). This problem underlay the study evaluating the efficacy of skin care product TOPICREM light soothing face cream in patients with hypersensitive normal and combination skin. The study included 30 patients: 12 (40%) men and 18 (60%) women aged 18 to 60 years (mean age 31±2.1 years). The irritable skin syndrome accompanied by rosacea was diagnosed in 10 (33.3%) patients; perioral dermatitis, in 4 (13.4%) patients; seborrheic dermatitis, in 9 (30%) patients; and retinoid dermatitis, 7 (23.3%) patients. The TOPICREM light soothing face cream was applied to the skin with light massage movements twice a day (in the morning and evening) for 1 month. The prevalence of skin process was estimated by specialists before the study was started, on the 8th, 15th and 30th days of the treatment, and included evaluation of tolerance, level of sensitivity, and the skin moisture status both visually and using a SOFT PLUS Callegari device (Italy). The findings revealed that TOPICREM light soothing face cream is characterized by high therapeutic efficacy and has a positive cosmetic effect. It moisturizes and restores the skin, improves skin's resistance to aggressive environmental factors, reduces skin discomfort and tightness. This cosmetic product can be used in complex treatment of the irritable facial skin syndrome.