Neutrophils are known to be phagocytic cells ensuring anti-infective defense of an organism. Their behavior in the blood is regulated by several classes of adhesion proteins, including selectins, integrins, and immunoglobulins. There is, however, almost no information on the effect of morphological changes in these cells in patients with psoriasis on the level of adhesion molecule expression on neutrophils. The aim of the study was to determine the level of adhesion molecule expression by neutrophils depending on their nuclear segmentation. Material and Methods. The level of adhesion molecule expression by neutrophils was measured in venous blood of 71 patients with psoriasis and 50 healthy volunteers aged 20 to 60 by flow cytometry. The cytoscopy examination of neutrophilic leukocytes was performed by counting the average number of nuclear fragments in 100 cells. Results. No differences in the total number of neutrophils between patients with psoriasis and healthy volunteers were revealed. However, a significant decrease in the segmentation index in patients with psoriasis was observed due to the increased amounts of 2-3 segmental forms and decreased concentration of neutrophils with 4 and 5 segments in the nucleus, which was accompanied by lower levels of expression of adhesion molecules involved in rolling adhesion, tight adhesion, and transmigration. Decreased concentrations of neutrophils with L-selectin molecules (CD62L), LFA-1 (CD11a/CD18), ICAM-1 (CD54), LFA-3 (CD58), PECAM-1 (CD31) were observed. Conclusions. Changes in nuclear segmentation in patients with psoriasis may be indicative of changes occurring in the non-mitotic bone marrow pool. Segmentation of the nuclei of neutrophils in non-mitotic pool can be regarded as a compensatory response induced by enhanced migration of neutrophils from the microvasculature into the tissues. Meanwhile, more intense migration of 2-3 segmental forms of neutrophils in patients with psoriasis may explain the lesser rate of neutrophil apoptosis.