Relevance of the problem is related to the increased number of patients with inflammatory diseases of the urinary tract in combination with cytomegalovirus (CMV) infection. Meanwhile, despite the rather large range of treatment methods, it is not always possible to take control over the disease. Objective. To improve therapy of urogenital tract inflammatory diseases accompanied by the reactivation of CMV infection associated with co-infections using Panavir drug and antibacterial therapy. Material and methods. The study involved 136 males with CMV infection. Laser treatment was performed using the Matrix urologist magneto-laser complex with a KLO3 radiating head through a P-3 rectal optical nozzle (parameters: wavelength of 0.63 µm, power 5 W, frequency 80 Hz, time 5 min). The course included 10 sessions every other day concomitantly with administration of Panavir and antibiotic therapy. Results. Combined therapy using the Matrix urologist magneto-laser complex and Panavir in patients with reactivated CMV infection in the pelvic organs was successful in 86.89% of cases.