The paper provides and analyzes the data of a follow-up of 22 patients with common chronic dermatoses (psoriasis, atopic dermatitis) who were constantly admitted to the clinic of the Nizhny Dermatovenereology Research Institute for treatment for a few years (3-10 years). The body's metabolic changes were investigated from the spectrum of protein fractions and major immunoglobulin classes (IgА, IgМ, and IgG), the concentration of effective albumin, the level of circulating immune complexes, average mass molecules, and the activities of glutathione transferase, trypsin, and α2-macroglobulin. Despite the fairly noticeable clinical efficacy of current agents (immunodepressants, protein preparations), prolonged chronic skin inflammation was shown to lead to the progression of endointoxication processes in the body, mainly those of protein origin, and to the diminished functional activity of detoxifying organs.