Clinical and laboratory aspects of ultrasound treatment for chronic wounds

Stavchikov E.L.; Zinovkin I.V.; Savostenko I.Ya.; Marochkov A.V.

doi:https://doi.org/10.17116/hirurgia202509136

Stavchikov E.L.

Mogilev Regional Clinical Hospital;
Vitebsk State Order of Friendship of Peoples Medical University

ORCID: 0000-0001-5147-5274

Zinovkin I.V.

Mogilev Regional Clinical Hospital

ORCID: 0009-0004-4168-3183

Savostenko I.Ya.

Mogilev Regional Clinical Hospital

ORCID: 0009-0004-4751-5551

Marochkov A.V.

Mogilev Regional Clinical Hospital;
Vitebsk State Order of Friendship of Peoples Medical University

ORCID: 0000-0001-5092-8315

Clinical and laboratory aspects of ultrasound treatment for chronic wounds

Authors:

Stavchikov E.L., Zinovkin I.V., Savostenko I.Ya., Marochkov A.V.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2025;(9): 36‑43

DOI: 10.17116/hirurgia202509136

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To cite this article:

Stavchikov EL, Zinovkin IV, Savostenko IYa, Marochkov AV. Clinical and laboratory aspects of ultrasound treatment for chronic wounds. Pirogov Russian Journal of Surgery. 2025;(9):36‑43. (In Russ.)
https://doi.org/10.17116/hirurgia202509136

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)

Использование инфографики авторами научных работ

Abstract:

OBJECTIVE

To evaluate clinical and laboratory effectiveness of ultrasound treatment for purulent wounds.

MATERIAL AND METHODS

The study enrolled 46 patients with purulent wounds divided into the main group (23 patients, ultrasonic treatment) and the control group (23 patients, traditional treatment). We assessed treatment effectiveness considering visual data, quality of granulation tissue, wound defect area and marginal epithelialization, complete blood count and C-reactive protein. Smear prints and acidity of wound discharge were analyzed.

RESULTS

In the main group, there was a faster completion of inflammatory phase and transition to proliferative one. This was accompanied by earlier granulations, reduced wound area and active marginal epithelialization with neutral pH of wound discharge. Neutrophil-lymphocytic and platelet-lymphocytic ratios significantly decreased after 3 days (2.56 and 118.23, respectively, p<0.05) compared to the control group. This decrease persisted at all stages of the study. After 10 days, NLR and TLR in the main group were 1.88 and 96.12, in the control group — 2.48 and 118.87, respectively. Serum CRP significantly decreased after 3 days in the main group (67.45 mg/l). After 10 days, CRP in the main group was 20.01 mg/l, in the control group — 56.87 mg/l (p<0.05).

CONCLUSION

Ultrasonic treatment of purulent wounds significantly improves cytological picture of wounds, accelerates wound debridement from devitalized tissues and epithelization, as well as reduces inflammation. These findings indicate higher effectiveness of treatment.

Keywords:

purulent wounds

ultrasonic treatment

efficiency criteria

Authors:

Stavchikov E.L.

Mogilev Regional Clinical Hospital;
Vitebsk State Order of Friendship of Peoples Medical University

ORCID: 0000-0001-5147-5274

Zinovkin I.V.

Mogilev Regional Clinical Hospital

ORCID: 0009-0004-4168-3183

Savostenko I.Ya.

Mogilev Regional Clinical Hospital

ORCID: 0009-0004-4751-5551

Marochkov A.V.

Mogilev Regional Clinical Hospital;
Vitebsk State Order of Friendship of Peoples Medical University

ORCID: 0000-0001-5092-8315

Received:

31.10.2024

Accepted:

19.11.2024

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References:

Kuz’michev AS, Bogatikov AA, Dobrecov KG, Zajceva IV. Primenenie nanochastic v lechenii gnojnyh ran. Rossijskie biomedicinskie issledovaniya. 2022;7(3):36-42. (In Russ.). https://doi.org/10.56871/9654.2022.99.32.006
Grigor’yan AYu, Bezhin AI, Pankrusheva TA, Zhilyaeva LV, Mishina ES, Chekmareva MS. Eksperimental’naya ocenka osobennostej techeniya ranevogo processa pri ispol’zovanii original’nogo ranevogo pokrytiya. Sibirskoe medicinskoe obozrenie. 2023;3(141):93-99. (In Russ.).
Proshin AV, Sulimanov RA, Zavalij IP, Rebinok AV. Processy reparativnoj regeneracii v gnojnyh ranah pri mestnom sochetannom lechenii fizicheskimi metodami i biologicheski aktivnymi materialami. Vestnik Novgorodskogo gosudarstvennogo universiteta im. Yaroslava Mudrogo. 2017;101:61-65. (In Russ.).
Chen Y, Du P, Lv G. A meta-analysis examined the effect of oxidised regenerated cellulose/collagen dressing on the management of chronic skin wounds. Int Wound J. 2023;20(5):1544-1551. https://doi.org/10.1111/iwj.14009
Rajhathy EM, Meer JV, Valenzano T, et al. Wound irrigation versus swabbing technique for cleansing noninfected chronic wounds: A systematic review of differences in bleeding, pain, infection, exudate, and necrotic tissue. J Tissue Viability. 2023;32(1):136-143. https://doi.org/10.1016/j.jtv.2022.11.002
Heras KL, Igartua M, Santos-Vizcaino E, Hernandez RM. Cell-based dressings: A journey through chronic wound management. Biomater Adv. 2022;135:212738. https://doi.org/10.1016/j.bioadv.2022.212738
Kurbanova CG, Smol’kina AV, Chebykin SG, Barbashin SI. Opyt lecheniya gnojnyh ran metodom tangencial’noj nekrektomii i autodermoplastiki. Vestnik novyh medicinskih tekhnologij. 2024;3(2):44-47. (In Russ.). https://doi.org/10.24412/1609-2163-2024-2-44-47
Mitish VA, Paskhalova YuS, Mun’os Sepeda PA, Ushakov AA, Blatun LA, Borisov IV, Magomedova SD. Ul’trazvukovaya kavitaciya v lechenii nejroishemicheskoj formy sindroma diabeticheskoj stopy pri nalichii bioplenochnyh form bakterij (obzor literatury). Rany i ranevye infekcii. Zhurnal imeni professora B.M. Kostyuchyonka. 2020;7(3):20-30. (In Russ.). https://doi.org/10.25199/2408-9613-2020-7-3-20-31
Vinnik YuS, Kochetova LV, Kulikova AB, Medvedeva NN. Effektivnost’ ozonoterapii i ul’trazvuka pri regeneracii inficirovannoj rany v eksperimente. Sibirskoe medicinskoe obozrenie. 2022;3(135):100-104. (In Russ.). https://doi.org/10.20333/25000136-2022-3-100-104
Zhang K, Ding S, Lyu X, Tan Q, Wang Z. Correlation between the platelet-to-lymphocyte ratio and diabetic foot ulcer in patients with type 2 diabetes mellitus. J Clin Lab Anal. 2021;35(4):e23719. https://doi.org/10.1002/jcla.23719
Rizo-Téllez, SA., Sekheri, M, Filep, JG. C-reactive protein: a target for therapy to reduce inflammation. Frontiers in immunology. 2023;14,1237729. https://doi.org/10.3389/fimmu.2023.1237729
Borodina MA, Naser NR, Batyrshin IM, Sklizkov DS, Ryazanova EP, Kozhevnikov VB. Ob»ektivnye metody ocenki dinamiki ranevogo processa. Vestnik Nacional’nogo mediko-hirurgicheskogo Centra im. N.I. Pirogova. 2021;16(2):61-65. (In Russ.). https://doi.org/10.25881/20728255_2021_16_2_61
Rubanov LN, Yarec YuI, Dundarov ZA. Kliniko-laboratornoe podtverzhdenie effektivnosti ispol’zovaniya ul’trazvukovogo debridmenta hronicheskoj rany v processe podgotovki pacientov k autodermoplastike. Novosti hirurgii. 2012;20(5):70-76. (In Russ.). https://doi.org/10.13140/RG.2.1.4525.7121
Flores-Escobar S, Álvaro-Afonso FJ, García-Álvarez Y, López-Moral M, Lázaro-Martínez JL, García-Morales E. Ultrasound-Assisted Wound (UAW) Debridement in the Treatment of Diabetic Foot Ulcer: A Systematic Review and Meta-Analysis. J Clin Med. 2022;11(7):1911. https://doi.org/10.3390/jcm11071911