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Krylov N.N.

Sechenov First Moscow State Medical University (Sechenov University)

Kazhlaev A.Yu.

Sechenov First Moscow State Medical University (Sechenov University)

Karpenko I.V.

Sechenov First Moscow State Medical University (Sechenov University)

Batoev S.D.

Sechenov First Moscow State Medical University (Sechenov University)

In searching for perfect blood substitute. Creation and application of perftorane

Authors:

Krylov N.N., Kazhlaev A.Yu., Karpenko I.V., Batoev S.D.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2024;(2): 111‑117

DOI: 10.17116/hirurgia2024021111

Views: 727

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Table of contents

To cite this article:

Krylov NN, Kazhlaev AYu, Karpenko IV, Batoev SD. In searching for perfect blood substitute. Creation and application of perftorane. Pirogov Russian Journal of Surgery. 2024;(2):111‑117. (In Russ.)
https://doi.org/10.17116/hirurgia2024021111

Подписка 2025 (Pirogov Russian Journal of Surgery)
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The article is devoted to historiography of perfluorocarbons, as well as discoverers of perftorane and their discoveries. There would be no national priority in transfusiology without these discoveries. Perftorane is the only one of the world series of perfluorocarbon emulsion drugs that has passed all phases of clinical trials. Perftorane has been used in clinical medicine for 30 years.

Keywords:

perfluorocarbons
perftorane
clinical application

Authors:

Krylov N.N.

Sechenov First Moscow State Medical University (Sechenov University)

Kazhlaev A.Yu.

Sechenov First Moscow State Medical University (Sechenov University)

Karpenko I.V.

Sechenov First Moscow State Medical University (Sechenov University)

Batoev S.D.

Sechenov First Moscow State Medical University (Sechenov University)

Received:

17.10.2023

Accepted:

15.11.2023

List of references:

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  10. Maevskii EI. Possible causes of acute reactogenicity of perfluorocarbon emulsions. Part 1. Perfluorane. Proceedings of the Institute of Engineering Physics. 2016;1(39):79-87. (In Russ.).
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  14. Monk TG, Winston RS, Wahr JA, et al.: Perflubron emulsion is more effective than blood for transfusion trigger reversal [Abstract]. Anesth Analg. 1998;86(suppl):142. 
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  16. Spence RK, McCoy S, Costabile J, Norcross ED, Pello MJ, Alexander JB, Wisdom C, Camishion RC. Fluosol DA-20 in the treatment of severe anemia: randomized, controlled study of 46 patients. Critical Care Medicine. 1990;18(11):1227-1230. https://doi.org/10.1097/00003246-199011000-00008
  17. Moroz VV, Krylov NL, Ivanitsky GR, Kaydash AN, Onishchenko NA, Simanov VA, Vorobyov SI. Application of perftoran in clinical medicine. Anesthesiology and resuscitation. Application. Alternatives to blood transfusions in surgery. M.: Medicine; 1999;126-135. (In Russ.).
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  20. Vecherko AV, Glushchenko YuI, Zaraev AA, Filina NG, Shkuropatov YuF, Bondar OG. The use of perfluorane in medical practice (according to the results of the questionnaire). Transfusiology. 2003;1(4):54-56. (In Russ.).
  21. Maevsky E, Ivanitsky G, Bogdanova L, Axenova O, Karmen N, Zhiburt E, Senina R, Pushkin S, Maslennikov I, Orlov A, Marinicheva I. Clinical results of Perftoran application: present and future. Artificial Cells, Blood Substitutes, and. Immobilization Biotechnology. 2005;33(1):37-46.  https://doi.org/10.1081/bio-200046654
  22. Verdin-Vasquez RC, Zepeda-Perez C, Ferra-Ferrer R, Chavez-Negrete A, Contreras F, Barroso-Aranda J. Use of perftoran emulsion to decrease allogeneic blood transfusion in cardiac surgery: clinical trial. Artificial Cells, Blood Substitutes, and. Immobilization Biotechnology. 2006;34(4):433-454.  https://doi.org/10.1080/10731190600683969
  23. Lowe KC. Chapter 25 — Fluosol: The First Commercial Injectable Perfluorocarbon Oxygen Carrier. In: Blood Substitutes. Winslow RM, ed. Academic Press; 2006;276-287.  https://doi.org/10.1016/b978-012759760-7/50034-2
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