The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Krylov N.N.

Sechenov First Moscow State Medical University (Sechenov University)

Kazhlaev A.Yu.

Sechenov First Moscow State Medical University (Sechenov University)

Karpenko I.V.

Sechenov First Moscow State Medical University (Sechenov University)

Batoev S.D.

Sechenov First Moscow State Medical University (Sechenov University)

In searching for perfect blood substitute. Creation and application of perftorane

Authors:

Krylov N.N., Kazhlaev A.Yu., Karpenko I.V., Batoev S.D.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2024;(2): 111‑117

Read: 3007 times


To cite this article:

Krylov NN, Kazhlaev AYu, Karpenko IV, Batoev SD. In searching for perfect blood substitute. Creation and application of perftorane. Pirogov Russian Journal of Surgery. 2024;(2):111‑117. (In Russ.)
https://doi.org/10.17116/hirurgia2024021111

References:

  1. Fabian TC. Perfluorocarbons. The Journal of Trauma. 2011;70(5 suppl):42-44.  https://doi.org/10.1097/TA.0b013e31821a5a3f
  2. Latson GW. Perftoran (Vidaphor)-Introduction to Western Medicine. Shock. 2019;52(1S suppl 1):65-69.  https://doi.org/10.1097/SHK.0000000000001063
  3. Kylstra JA, Tissing MOo, van der Maen. Of mice as fish. Transactions of the American Society for Artificial Internal Organs. 1962;8:378-383.  https://doi.org/10.1097/00002480-196204000-00077
  4. Clark LC Jr, Gollan F. Survival of mammals breathing organic liquids equilibrated with oxygen at atmospheric pressure. Science. 1966;152(3730):1755-1756. https://doi.org/10.1126/science.152.3730.1755
  5. Gollan F, Clark L. Organ perfusion with fluorocarbon. Physiologist. 1966;9:191. 
  6. Sloviter HA, Kamimoto T. Erythrocyte Substitute for Perfusion of Brain. Nature. 1967;216:458-460. 
  7. Geyer RP, Monroe RG, Taylor K: Survival of rats totally perfused with a fluorocarbon-detergent preparation. In: Organ Perfusion and Preservation. Norman J.C., Folkman J., Hardison W.G., Rudolf L.E., Veith F.J., eds. New York: Appleton-Cen-tury-Crofts; 1968;85-96. 
  8. Honda K, Hoshino S, Shoji M, Usuba A, Motoki R, Tsuboi M, Inoue H, Iwaya F. Clinical use of a blood substitute. The New England Journal of Medicine. 1980;303(7):391-392.  https://doi.org/10.1056/NEJM198008143030710
  9. Suyama T, Yokoyama K, Naito R. Development of a perfluorochemical whole blood substitute (Fluosol-DA, 20%)-an overview of clinical studies with 185 patients. Progress in clinical and biological research. 1981;55:609-628. 
  10. Maevskii EI. Possible causes of acute reactogenicity of perfluorocarbon emulsions. Part 1. Perfluorane. Proceedings of the Institute of Engineering Physics. 2016;1(39):79-87. (In Russ.).
  11. Интервью с мамой А. Гришиной. Личный архив автора. Personal Communication, August 2023. (In Russ.).
  12. Krylov HL, Moroz VV, Beloyartsev FF. The use of fluorocarbon blood substitute perfluorane in the clinic. Military Medical Journal. 1985;306(8):36-40. (In Russ.).
  13. Chen HS, Yang ZH. Perfluorocarbon as blood substitute in clinical applications and in war casualties. Biomaterials, artificial cells, and artificial organs. 1988;16:403-409. 
  14. Monk TG, Winston RS, Wahr JA, et al.: Perflubron emulsion is more effective than blood for transfusion trigger reversal [Abstract]. Anesth Analg. 1998;86(suppl):142. 
  15. Spahn DR, van Brempt R, Theilmeier G, Reibold JP, Welte M, Heinzerling H, Birck KM, Keipert PE, Messmer K, Heinzerling H, Birck KM, Keipert PE, Messmer K. Perflubron emulsion delays blood transfusions in orthopedic surgery. European Perflubron Emulsion Study Group. Anesthesiology. 1999;91(5):1195-1208. https://doi.org/10.1097/00000542-199911000-00009
  16. Spence RK, McCoy S, Costabile J, Norcross ED, Pello MJ, Alexander JB, Wisdom C, Camishion RC. Fluosol DA-20 in the treatment of severe anemia: randomized, controlled study of 46 patients. Critical Care Medicine. 1990;18(11):1227-1230. https://doi.org/10.1097/00003246-199011000-00008
  17. Moroz VV, Krylov NL, Ivanitsky GR, Kaydash AN, Onishchenko NA, Simanov VA, Vorobyov SI. Application of perftoran in clinical medicine. Anesthesiology and resuscitation. Application. Alternatives to blood transfusions in surgery. M.: Medicine; 1999;126-135. (In Russ.).
  18. Maevskii EI, Aksenova OG, Bogdanova LA, Moroz VV, Senina RYa, Pushkin SYu, Ivanitsky GR. Analysis of side effects and clinical effects during phase 1 and 2 clinical trials of perfluorane. Bulletin of the Russian Blood Service. 2001;4:23-29. (In Russ.).
  19. Krichevskii AL. Compression injury of soft tissues. Guidelines for doctors. Krichevsky A.L., ed. Kemerovo: Kuzbassmedkat; 2005;333. (In Russ.).
  20. Vecherko AV, Glushchenko YuI, Zaraev AA, Filina NG, Shkuropatov YuF, Bondar OG. The use of perfluorane in medical practice (according to the results of the questionnaire). Transfusiology. 2003;1(4):54-56. (In Russ.).
  21. Maevsky E, Ivanitsky G, Bogdanova L, Axenova O, Karmen N, Zhiburt E, Senina R, Pushkin S, Maslennikov I, Orlov A, Marinicheva I. Clinical results of Perftoran application: present and future. Artificial Cells, Blood Substitutes, and. Immobilization Biotechnology. 2005;33(1):37-46.  https://doi.org/10.1081/bio-200046654
  22. Verdin-Vasquez RC, Zepeda-Perez C, Ferra-Ferrer R, Chavez-Negrete A, Contreras F, Barroso-Aranda J. Use of perftoran emulsion to decrease allogeneic blood transfusion in cardiac surgery: clinical trial. Artificial Cells, Blood Substitutes, and. Immobilization Biotechnology. 2006;34(4):433-454.  https://doi.org/10.1080/10731190600683969
  23. Lowe KC. Chapter 25 — Fluosol: The First Commercial Injectable Perfluorocarbon Oxygen Carrier. In: Blood Substitutes. Winslow RM, ed. Academic Press; 2006;276-287.  https://doi.org/10.1016/b978-012759760-7/50034-2
  24. Khan F, Singh K, Friedman MT. Artificial Blood: The History and Current Perspectives of Blood Substitutes. Discoveries. 2020;8(1):e104. https://doi.org/10.15190/d.2020.1
  25. Dvornikov MV, Medenkov AA, Frantsuzov VN. Development of new technologies to save the lives of the wounded and sick. Aerospace medicine, psychology and ergonomics. 2020;1:76-83. (In Russ.).
  26. Mayevsky EI, Golovnenkova AE, Alekseev SV, Kaptsov AV, Bogdanova LA. Perftoran. The untapped potential of medicine against COVID-19. Medline.ru. 2020;21:854-869. (In Russ.).
  27. Интервью с членом-корреспондентом РАН Г.Р. Иваницким. Личный архив автора. Personal Communication, Mart 2023. (In Russ.).

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.