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Danilevskaya O.V.

Research Pulmonology Institute of the Federal Medical Biological Agency;
Moscow City Clinical Oncology Hospital No. 1

Chernikova E.N.

Loginov Moscow Clinical Research Center

Esakov Yu.S.

Moscow City Clinical Oncology Hospital No. 1

Averyanov A.V.

Research Pulmonology Institute of the Federal Medical Biological Agency

Karnaukhov N.S.

Loginov Moscow Clinical Research Center

Shishin K.V.

Loginov Moscow Clinical Research Center

Transbronchial cryobiopsy for mediastinal lesions: a pilot study

Authors:

Danilevskaya O.V., Chernikova E.N., Esakov Yu.S., Averyanov A.V., Karnaukhov N.S., Shishin K.V.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2023;(11): 16‑24

DOI: 10.17116/hirurgia202311116

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Table of contents

TRANSBRONCHIAL CRYOBIOPSY FOR MEDIASTINAL LESIONS: A PILOT STUDY
TRANSBRONCHIAL CRYOBIOPSY FOR MEDIASTINAL LESIONS: A PILOT STUDY

To cite this article:

Danilevskaya OV, Chernikova EN, Esakov YuS, Averyanov AV, Karnaukhov NS, Shishin KV. Transbronchial cryobiopsy for mediastinal lesions: a pilot study. Pirogov Russian Journal of Surgery. 2023;(11):16‑24. (In Russ.)
https://doi.org/10.17116/hirurgia202311116

Подписка 2025-2 (Pirogov Russian Journal of Surgery)
МСФ на ЯМ
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OBJECTIVE

To describe a novel transbronchial cryobiopsy technique for mediastinal lesions after initial ultrasound assessment and EBUS-TBNA.

MATERIAL AND METHODS

Transbronchial cryobiopsy (TBCB) was performed in 35 patients with suspicious mediastinal lesions between November 2020 and September 2022. Age of patients ranged from 22 to 75 years (median 50 [39; 62]). Men-to-women ratio was 13:22.

RESULTS

According to morphological data, patients with sarcoidosis (n=13), NSCLC (n=7) and metastases of other tumors (n=3) prevailed. There were patients with B-cell lymphoma (n=1), Castleman disease (n=1) and small cell lung cancer (n=2). Among 15 biopsies for immunohistochemical examination, samples were sufficient for final morphological conclusion in 11 (73.3%) cases (95% CI 48.5—89.1). In 4 (11.4%) cases (95% CI 4.5—26), examination was uninformative. Repeated biopsy was performed in 2 cases, and sarcoidosis of thoracic lymph nodes was confirmed. Sensitivity, specificity and accuracy of transbronchial cryobiopsy were 93.3, 100 and 94%, respectively. There were no clinically significant complications. In one case, chest X-ray revealed pneumomediastinum without need for additional treatment.

CONCLUSION

Transbronchial mediastinal cryobiopsy is a perspective method for diagnosis of mediastinal neoplasms. Apparently, this approach may be advisable in patients with suspected sarcoidosis or lymphoproliferative diseases.

Keywords:

transbronchial mediastinal cryobiopsy
endobronchial ultrasound needle aspiration (EBUS)
mediastinal lesions

Authors:

Danilevskaya O.V.

Research Pulmonology Institute of the Federal Medical Biological Agency;
Moscow City Clinical Oncology Hospital No. 1

Chernikova E.N.

Loginov Moscow Clinical Research Center

Esakov Yu.S.

Moscow City Clinical Oncology Hospital No. 1

Averyanov A.V.

Research Pulmonology Institute of the Federal Medical Biological Agency

Karnaukhov N.S.

Loginov Moscow Clinical Research Center

Shishin K.V.

Loginov Moscow Clinical Research Center

Received:

04.04.2023

Accepted:

12.05.2023

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