Transbronchial cryobiopsy for mediastinal lesions: a pilot study

Danilevskaya O.V.; Chernikova E.N.; Esakov Yu.S.; Averyanov A.V.; Karnaukhov N.S.; Shishin K.V.

doi:https://doi.org/10.17116/hirurgia202311116

Danilevskaya O.V.

Research Pulmonology Institute of the Federal Medical Biological Agency;
Moscow City Clinical Oncology Hospital No. 1

ORCID: 0000-0002-7573-3554

Chernikova E.N.

Loginov Moscow Clinical Research Center

Esakov Yu.S.

Moscow City Clinical Oncology Hospital No. 1

ORCID: 0000-0002-5933-924X

Averyanov A.V.

Research Pulmonology Institute of the Federal Medical Biological Agency

ORCID: 0000-0003-1031-6933

Karnaukhov N.S.

Loginov Moscow Clinical Research Center

ORCID: 0000-0003-0625-2973

Shishin K.V.

Loginov Moscow Clinical Research Center

ORCID: 0000-0003-0010-5294

Transbronchial cryobiopsy for mediastinal lesions: a pilot study

Authors:

Danilevskaya O.V., Chernikova E.N., Esakov Yu.S., Averyanov A.V., Karnaukhov N.S., Shishin K.V.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2023;(11): 16‑24

DOI: 10.17116/hirurgia202311116

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To cite this article:

Danilevskaya OV, Chernikova EN, Esakov YuS, Averyanov AV, Karnaukhov NS, Shishin KV. Transbronchial cryobiopsy for mediastinal lesions: a pilot study. Pirogov Russian Journal of Surgery. 2023;(11):16‑24. (In Russ.)
https://doi.org/10.17116/hirurgia202311116

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)

Использование инфографики авторами научных работ

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Abstract:

OBJECTIVE

To describe a novel transbronchial cryobiopsy technique for mediastinal lesions after initial ultrasound assessment and EBUS-TBNA.

MATERIAL AND METHODS

Transbronchial cryobiopsy (TBCB) was performed in 35 patients with suspicious mediastinal lesions between November 2020 and September 2022. Age of patients ranged from 22 to 75 years (median 50 [39; 62]). Men-to-women ratio was 13:22.

RESULTS

According to morphological data, patients with sarcoidosis (n=13), NSCLC (n=7) and metastases of other tumors (n=3) prevailed. There were patients with B-cell lymphoma (n=1), Castleman disease (n=1) and small cell lung cancer (n=2). Among 15 biopsies for immunohistochemical examination, samples were sufficient for final morphological conclusion in 11 (73.3%) cases (95% CI 48.5—89.1). In 4 (11.4%) cases (95% CI 4.5—26), examination was uninformative. Repeated biopsy was performed in 2 cases, and sarcoidosis of thoracic lymph nodes was confirmed. Sensitivity, specificity and accuracy of transbronchial cryobiopsy were 93.3, 100 and 94%, respectively. There were no clinically significant complications. In one case, chest X-ray revealed pneumomediastinum without need for additional treatment.

CONCLUSION

Transbronchial mediastinal cryobiopsy is a perspective method for diagnosis of mediastinal neoplasms. Apparently, this approach may be advisable in patients with suspected sarcoidosis or lymphoproliferative diseases.

Keywords:

transbronchial mediastinal cryobiopsy

endobronchial ultrasound needle aspiration (EBUS)

mediastinal lesions

Authors:

Danilevskaya O.V.

Research Pulmonology Institute of the Federal Medical Biological Agency;
Moscow City Clinical Oncology Hospital No. 1

ORCID: 0000-0002-7573-3554

Chernikova E.N.

Loginov Moscow Clinical Research Center

Esakov Yu.S.

Moscow City Clinical Oncology Hospital No. 1

ORCID: 0000-0002-5933-924X

Averyanov A.V.

Research Pulmonology Institute of the Federal Medical Biological Agency

ORCID: 0000-0003-1031-6933

Karnaukhov N.S.

Loginov Moscow Clinical Research Center

ORCID: 0000-0003-0625-2973

Shishin K.V.

Loginov Moscow Clinical Research Center

ORCID: 0000-0003-0010-5294

Received:

04.04.2023

Accepted:

12.05.2023

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