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Timerbulatov M.V.

Bashkir State Medical University

Aitova L.R.

Bashkir State Medical University

Grishina E.E.

Bashkir State Medical University

Sakaev E.M.

Bashkir State Medical University

Shchekin V.S.

Ufa City Clinical Hospital No. 21

Shchekin S.V.

Ufa City Clinical Hospital No. 21

Nizamutdinov T.R.

Bashkir State Medical University

Severe pseudomembranous colitis in patients with previous coronavirus infection

Authors:

Timerbulatov M.V., Aitova L.R., Grishina E.E., Sakaev E.M., Shchekin V.S., Shchekin S.V., Nizamutdinov T.R.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2022;(8): 53‑60

DOI: 10.17116/hirurgia202208153

Read: 4863 times

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Table of contents

SEVERE PSEUDOMEMBRANOUS COLITIS IN PATIENTS WITH PREVIOUS CORONAVIRUS INFECTION
SEVERE PSEUDOMEMBRANOUS COLITIS IN PATIENTS WITH PREVIOUS CORONAVIRUS INFECTION

To cite this article:

Timerbulatov MV, Aitova LR, Grishina EE, Sakaev EM, Shchekin VS, Shchekin SV, Nizamutdinov TR. Severe pseudomembranous colitis in patients with previous coronavirus infection. Pirogov Russian Journal of Surgery. 2022;(8):53‑60. (In Russ.)
https://doi.org/10.17116/hirurgia202208153

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To analyze treatment outcomes in patients with severe pseudomembranous colitis and previous coronavirus infection.

MATERIAL AND METHODS

We retrospectively analyzed treatment outcomes, clinical, laboratory and histological data in convalescents of COVID-19 who admitted to the department of coloproctology for moderate-to-severe pseudomembranous colitis confirmed by endoscopic examination between 2020 and 2021.

RESULTS

There were 13 patients with moderate pseudomembranous colitis and 6 ones with severe pseudomembranous colitis. Mean period after recovery from coronavirus infection was 19 days. Endoscopy revealed whitish-yellow or gray raised plaques on colonic mucosa in all cases. Four patients with signs of peritonitis underwent emergency surgery. Three patients had perforation of caecum; one patient had perforation of sigmoid colon and widespread peritonitis. Two patients underwent urgent surgery for progressive toxic megacolon and ineffective therapy. Subtotal colectomy and ileostomy were performed in all cases. Histological examination revealed necrosis of not only superficial layer of colon mucosa typical for clostridial colitis, but also the entire thickness of mucosa, as well as submucosal and partially muscular layers in some cases. Mucosal crypt atrophy, fibrinoid effusion in muscular layer, diffuse polymorphonuclear cell infiltration and necrosis of muscular and submucosal nerve plexuses, as well as necrosis of vascular walls with deposition of hyaline-like structures characterize microcirculatory ischemic processes in the colon wall.

CONCLUSION

Severe pseudomembranous colitis associated with COVID-19 may not be associated with clostridial infection. Further analysis of possible ischemic etiology and pathogenesis of gastrointestinal lesions in COVID-19 is needed for preventive and therapeutic measures.

Keywords:

pseudomembranous colitis
clostridium colitis
complications of COVID-19
ischemic colitis

Authors:

Timerbulatov M.V.

Bashkir State Medical University

Aitova L.R.

Bashkir State Medical University

Grishina E.E.

Bashkir State Medical University

Sakaev E.M.

Bashkir State Medical University

Shchekin V.S.

Ufa City Clinical Hospital No. 21

Shchekin S.V.

Ufa City Clinical Hospital No. 21

Nizamutdinov T.R.

Bashkir State Medical University

Received:

15.11.2021

Accepted:

10.12.2021

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