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Chupin A.V.

Vishnevsky National Medical Research Center of Surgery

Verdikhanov N.I.

Sklifosovsky Research Institute of Emergency Care

Golovyuk A.L.

Vishnevsky National Medical Research Center of Surgery

Modern conceptions on neck paragangliomas

Authors:

Chupin A.V., Verdikhanov N.I., Golovyuk A.L.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2022;(7): 64‑70

DOI: 10.17116/hirurgia202207164

Read: 9949 times

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Table of contents

MODERN CONCEPTIONS ON NECK PARAGANGLIOMAS
MODERN CONCEPTIONS ON NECK PARAGANGLIOMAS

To cite this article:

Chupin AV, Verdikhanov NI, Golovyuk AL. Modern conceptions on neck paragangliomas. Pirogov Russian Journal of Surgery. 2022;(7):64‑70. (In Russ.)
https://doi.org/10.17116/hirurgia202207164

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Neck paragangliomas are orphan diseases with incidence 1:30 000—1:100 000. Life expectancy is poor in patients with distant metastasis (5-year overall survival 11.8%), whereas 5-year overall survival in patients with regional metastasis is 76.8—82.4%. Meanwhile, there is still no any reliable tool for prediction of malignant potential of paraganglioma. Above-mentioned data indicate an importance of early diagnosis and timely treatment of neck paragangliomas. Total resection of tumor in ablastic conditions is a gold standard of treatment. However, surgery is associated with a high risk of neurovascular complications and requires multidisciplinary approach. Nevertheless, new knowledge dedicated to different aspects of pathogenesis of neck paraganglioma, diagnosis and treatment arise every year. This review is devoted to modern data on neck paragangliomas.

Keywords:

carotid body tumor
carotid paraganglioma
vagal paraganglioma
vagal chemodectoma
neck paragangliomas

Authors:

Chupin A.V.

Vishnevsky National Medical Research Center of Surgery

Verdikhanov N.I.

Sklifosovsky Research Institute of Emergency Care

Golovyuk A.L.

Vishnevsky National Medical Research Center of Surgery

Received:

09.11.2021

Accepted:

15.12.2021

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References:

  1. Darouassi Y, Alaoui M, Mliha Touati M et al. Carotid Body Tumors: A Case Series and Review of the Literature. Ann Vasc Surg. 2017;43:265-271.  https://doi.org/10.1016/j.avsg.2017.03.167
  2. Pellitteri P. Paragangliomas of the head and Neck. Oral Oncology. 2004;40(6):563-575.  https://doi.org/10.1016/j.oraloncology.2003.09.004
  3. Wernick BD, Furlough CL, Patel U, et al. Contemporary management of carotid body tumors in a Midwestern academic center. Surgery. 2021;169(3):700-704.  https://doi.org/10.1016/j.surg.2020.07.030
  4. Lamblin E, Atallah I, Reyt E, Schmerber S, Magne J-L, Righini C. Neurovascular complications following carotid body paraganglioma resection. European Annals of Otorhinolaryngology, Head and Neck Diseases. 2016;133(5):319-324.  https://doi.org/10.1016/j.anorl.2016.05.006
  5. Kim Y, Goldenberg D. Anatomy, physiology, and genetics of paragangliomas. Operative Techniques in Otolaryngology-Head and Neck Surgery. 2016;27(1):2-6.  https://doi.org/10.1016/j.otot.2015.12.003
  6. Shamblin WR, ReMine WH, Sheps SG, Harrison EG Jr. Carotid body tumor (chemodectoma). Clinicopathologic analysis of ninety cases. Am J Surg. 1971;122(6):732-739.  https://doi.org/10.1016/0002-9610(71)90436-3
  7. Davila VJ, Chang JM, Stone WM, et al. Current surgical management of carotid body tumors. J Vasc Surg. 2016;64(6):1703-1710. https://doi.org/10.1016/j.jvs.2016.05.076
  8. Sajid MS, Hamilton G, Baker DM; Joint Vascular Research Group. A multicenter review of carotid body tumour management. Eur J Vasc Endovasc Surg. 2007;34(2):127-130.  https://doi.org/10.1016/j.ejvs.2007.01.015
  9. Gordon-Taylor G. On carotid tumors. Br J Surg. 1940;28(110):163-172.  https://doi.org/10.1002/bjs.18002811003
  10. Robertson V, Poli F, Hobson B, Saratzis A, Ross Naylor A. A Systematic Review and Meta-Analysis of the Presentation and Surgical Management of Patients With Carotid Body Tumours. Eur J Vasc Endovasc Surg. 2019;57(4):477-486.  https://doi.org/10.1016/j.ejvs.2018.10.038
  11. Persky M, Tran T. Acquired Vascular Tumors of the Head and Neck. Otolaryngol Clin North Am. 2018;51(1):255-274.  https://doi.org/10.1016/j.otc.2017.09.015
  12. Torrealba JI, Valdés F, Krämer AH, Mertens R, Bergoeing M, Mariné L. Management of Carotid Bifurcation Tumors: 30-Year Experience. Ann Vasc Surg. 2016;34:200-205.  https://doi.org/10.1016/j.avsg.2015.12.029
  13. Kikuta S, Iwanaga J, Kusukawa J, Tubbs RS. Carotid Sinus Nerve: A Comprehensive Review of Its Anatomy, Variations, Pathology, and Clinical Applications. World Neurosurg. 2019;127:370-374.  https://doi.org/10.1016/j.wneu.2019.04.064
  14. Schulz SA, Wöhler A, Beutner D, Angelov DN. Microsurgical anatomy of the human carotid body (glomus caroticum): Features of its detailed topography, syntopy and morphology. Ann Anat. 2016;204:106-113.  https://doi.org/10.1016/j.aanat.2015.11.009
  15. Shibao S, Akiyama T, Ozawa H, Tomita T, Ogawa K, Yoshida K. Descending musculospinal branch of the ascending pharyngeal artery as a feeder of carotid body tumors: Angio-architecture and embryological consideration. J Neuroradiol. 2020;47(3):187-192.  https://doi.org/10.1016/j.neurad.2018.10.002
  16. Kim GY, Lawrence PF, Moridzadeh RS, et al. New predictors of complications in carotid body tumor resection. J Vasc Surg. 2017;65(6):1673-1679. https://doi.org/10.1016/j.jvs.2016.12.124
  17. Bobadilla-Rosado LO, Garcia-Alva R, Anaya-Ayala JE, et al. Surgical Management of Bilateral Carotid Body Tumors. Ann Vasc Surg. 2019;57:187-193.  https://doi.org/10.1016/j.avsg.2018.10.019
  18. Jiang X, Fang G, Guo D, et al. Surgical Management of Carotid Body Tumor and Risk Factors of Postoperative Cranial Nerve Injury. World J Surg. 2020;44(12):4254-4260. https://doi.org/10.1007/s00268-020-05723-8
  19. Guilmette J, Sadow PM. A Guide to Pheochromocytomas and Paragangliomas. Surg Pathol Clin. 2019;12(4):951-965.  https://doi.org/10.1016/j.path.2019.08.009
  20. Mediouni A, Ammari S, Wassef M, et al. Malignant head/neck paragangliomas. Comparative study. Eur Ann Otorhinolaryngol Head Neck Dis. 2014;131(3):159-166.  https://doi.org/10.1016/j.anorl.2013.05.003
  21. Gu G, Wang Y, Liu B, et al. Distinct features of malignant carotid body tumors and surgical techniques for challengeable lesions: a case series of 11 patients. Eur Arch Otorhinolaryngol. 2020;277(3):853-861.  https://doi.org/10.1007/s00405-019-05740-x
  22. Hensen EF, Bayley JP. Recent advances in the genetics of SDH-related paraganglioma and pheochromocytoma. Fam Cancer. 2011;10(2):355-363.  https://doi.org/10.1007/s10689-010-9402-1
  23. Mannelli M, Castellano M, Schiavi F, et al. Clinically guided genetic screening in a large cohort of italian patients with pheochromocytomas and/or functional or nonfunctional paragangliomas. J Clin Endocrinol Metab. 2009;94(5):1541-1547. https://doi.org/10.1210/jc.2008-2419
  24. Heutink P, van der Mey AG, Sandkuijl LA, et al. A gene subject to genomic imprinting and responsible for hereditary paragangliomas maps to chromosome 11q23-qter. Hum Mol Genet. 1992;1(1):7-10.  https://doi.org/10.1093/hmg/1.1.7
  25. Hirawake H, Taniwaki M, Tamura A, Kojima S, Kita K. Cytochrome b in human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of the components in liver mitochondria and chromosome assignment of the genes for the large (SDHC) and small (SDHD) subunits to 1q21 and 11q23. Cytogenet Cell Genet. 1997;79(1-2):132-138.  https://doi.org/10.1159/000134700
  26. Mariman EC, van Beersum SE, Cremers CW, Struycken PM, Ropers HH. Fine mapping of a putatively imprinted gene for familial non-chromaffin paragangliomas to chromosome 11q13.1: evidence for genetic heterogeneity. Hum Genet. 1995;95(1):56-62.  https://doi.org/10.1007/BF00225075
  27. Hao HX, Khalimonchuk O, Schraders M, et al. SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma. Science. 2009;325(5944):1139-1142. https://doi.org/10.1126/science.1175689
  28. Astuti D, Latif F, Dallol A, et al. Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. Am J Hum Genet. 2001;69(1):49-54.  https://doi.org/10.1086/321282
  29. Niemann S, Müller U. Mutations in SDHC cause autosomal dominant paraganglioma, type 3. Nat Genet. 2000;26(3):268-270.  https://doi.org/10.1038/81551
  30. Neumann HP, Bausch B, McWhinney SR, et al. Germ-line mutations in nonsyndromic pheochromocytoma. N Engl J Med. 2002;346(19):1459-1466. https://doi.org/10.1056/NEJMoa020152
  31. Cohen S, Netterville J. Surgical management of vagal paragangliomas. Operative Techniques in Otolaryngology-Head and Neck Surgery. 2004;15(3):196-200.  https://doi.org/10.1016/j.otot.2004.07.004
  32. Khan MJ, Goldenberg D, Myssiorek D. Surgical management of vagal paraganglioma. Operative Techniques in Otolaryngology-Head and Neck Surgery. 2016;27(1):25-29.  https://doi.org/10.1016/j.otot.2015.12.007
  33. Wang X, Chen Y, Chen X, Xian J. Parapharyngeal space paraganglioma: distinguishing vagal paragangliomas from carotid body tumours using standard MRI. Clin Radiol. 2019;74(9):734.e1-734.e6.  https://doi.org/10.1016/j.crad.2019.04.018
  34. Mendenhall W, Amdur R. Radiotherapy for head and neck paragangliomas. Operative Techniques in Otolaryngology-Head and Neck Surgery. 2016;27(1):55-57.  https://doi.org/10.1016/j.otot.2015.12.011
  35. Hallett JW Jr, Nora JD, Hollier LH, Cherry KJ Jr, Pairolero PC. Trends in neurovascular complications of surgical management for carotid body and cervical paragangliomas: a fifty-year experience with 153 tumors. J Vasc Surg. 1988;7(2):284-291.  https://doi.org/10.1016/0741-5214(88)90147-4
  36. Matyakin EG, Dan VN, Shubin AA, Vel’sher LZ, Duditskaya TK. Paragangliomy shei (khemodektomy). M.: Verdana; 2005. (In Russ.).
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