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Volkov A.Yu.

Blokhin National Medical Research Center of Oncology

Nered S.N.

Blokhin National Medical Research Center of Oncology

Kozlov N.A.

Blokhin National Medical Research Center of Oncology

Stilidi I.S.

Blokhin National Medical Research Center of Oncology

Arkhiri P.P.

Blokhin National Medical Research Center of Oncology

Antonova E.Yu.

Blokhin National Medical Research Center of Oncology

Privezentsev S.A.

Pletnev City Clinical Hospital

Active surgical approach for retroperitoneal liposarcoma

Authors:

Volkov A.Yu., Nered S.N., Kozlov N.A., Stilidi I.S., Arkhiri P.P., Antonova E.Yu., Privezentsev S.A.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2021;(11): 5‑11

DOI: 10.17116/hirurgia20211115

Read: 2872 times

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Table of contents

ACTIVE SURGICAL APPROACH FOR RETROPERITONEAL LIPOSARCOMA
ACTIVE SURGICAL APPROACH FOR RETROPERITONEAL LIPOSARCOMA

To cite this article:

Volkov AYu, Nered SN, Kozlov NA, Stilidi IS, Arkhiri PP, Antonova EYu, Privezentsev SA. Active surgical approach for retroperitoneal liposarcoma. Pirogov Russian Journal of Surgery. 2021;(11):5‑11. (In Russ.)
https://doi.org/10.17116/hirurgia20211115

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To assess the influence of active surgical approach on the long-term postoperative outcomes in patients with retroperitoneal liposarcoma.

MATERIAL AND METHODS

A retrospective study included 190 patients with retroperitoneal liposarcoma. The effect of malignancy grade, adjuvant chemotherapy, number of separate tumor nodes in primary neoplasm and the first relapse, as well as the number of previous total resections on survival rate was analyzed.

RESULTS

Overall and relapse-free survival is significantly worse in patients with high-grade retroperitoneal liposarcoma (G2-3) compared to low-grade (G1) tumor (plog-rank=0.000). Multifocal growth of primary tumor (p=0.869; plog-rank=0.607) and multiple (>1) separately located nodes in abdominal cavity and retroperitoneal space at the first relapse (plog-rank=0.158 to 0.985) did not significantly impair prognosis after total resection of all types of retroperitoneal liposarcoma regardless malignancy grade. Adjuvant chemotherapy does not significantly improve relapse-free survival. Overall survival was significantly higher in patients who underwent ≥4 previous total resections compared to 1 surgical treatment for all types of retroperitoneal liposarcoma regardless malignancy grade (p=0.000; plog-rank=0.001).

CONCLUSION

The only potentially radical treatment for patients with retroperitoneal liposarcoma is surgery. We reported the advantages of active surgical approach for improvement of long-term outcomes in patients with retroperitoneal liposarcoma.

Keywords:

retroperitoneal liposarcoma
liposarcoma
active surgical approach
retroperitoneal tumors
adjuvant chemotherapy
multifocal growth

Authors:

Volkov A.Yu.

Blokhin National Medical Research Center of Oncology

Nered S.N.

Blokhin National Medical Research Center of Oncology

Kozlov N.A.

Blokhin National Medical Research Center of Oncology

Stilidi I.S.

Blokhin National Medical Research Center of Oncology

Arkhiri P.P.

Blokhin National Medical Research Center of Oncology

Antonova E.Yu.

Blokhin National Medical Research Center of Oncology

Privezentsev S.A.

Pletnev City Clinical Hospital

Received:

21.01.2021

Accepted:

08.04.2021

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