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Morozova M.M.

Petrovsky Russian Research Center of Surgery

Ivanova E.I.

National Medical Research Center for Therapy and Preventive Medicine

Chardarov N.K.

Petrovsky Russian Research Center of Surgery

Dolzhansky O.V.

Petrovsky Russian Scientific Center of Surgery

Shatveryan G.A.

Petrovsky Russian Research Center of Surgery

Kamalov Yu.R.

Petrovsky Russian Research Center of Surgery

Multiple hepatocellular adenomas and renal cell carcinoma associated with anabolic androgenic steroids

Authors:

Morozova M.M., Ivanova E.I., Chardarov N.K., Dolzhansky O.V., Shatveryan G.A., Kamalov Yu.R.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2021;(10): 105‑109

DOI: 10.17116/hirurgia2021101105

Read: 6592 times

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Table of contents

MULTIPLE HEPATOCELLULAR ADENOMAS AND RENAL CELL CARCINOMA ASSOCIATED WITH ANABOLIC ANDROGENIC STEROIDS
MULTIPLE HEPATOCELLULAR ADENOMAS AND RENAL CELL CARCINOMA ASSOCIATED WITH ANABOLIC ANDROGENIC STEROIDS

To cite this article:

Morozova MM, Ivanova EI, Chardarov NK, Dolzhansky OV, Shatveryan GA, Kamalov YuR. Multiple hepatocellular adenomas and renal cell carcinoma associated with anabolic androgenic steroids. Pirogov Russian Journal of Surgery. 2021;(10):105‑109. (In Russ.)
https://doi.org/10.17116/hirurgia2021101105

 
Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The authors report a rare case of combination of chromophobe renal cell carcinoma Grade 2 pT2aN0 with multiple hepatocellular adenomas in a 31-year-old bodybuilder who received anabolic androgenic steroids at high doses for 8 years. According to MRI data, over 15 liver adenomas and tumor in the lower segment of the right kidney were detected. The patients underwent laparascopic resection of the right kidney and liver segments 2, 3 and 4 with large adenomas. Histological study and immunohistochemistry revealed no malignancy signs in hepatocellular adenomas. Nuclear β-catenin expression was absent. Kidney tumor had a structure of chromophobe renal cell carcinoma. The patient is currently being followed-up due to residual small liver adenomas. In our opinion, liver adenomatosis and renal cancer have the same cause in this case (chronic toxic effect of androgens).

Keywords:

anabolic androgenic steroids
chromophobe renal cell carcinoma
hepatocellular adenomas
nuclear β-catenin expression

Authors:

Morozova M.M.

Petrovsky Russian Research Center of Surgery

Ivanova E.I.

National Medical Research Center for Therapy and Preventive Medicine

Chardarov N.K.

Petrovsky Russian Research Center of Surgery

Dolzhansky O.V.

Petrovsky Russian Scientific Center of Surgery

Shatveryan G.A.

Petrovsky Russian Research Center of Surgery

Kamalov Yu.R.

Petrovsky Russian Research Center of Surgery

Received:

25.11.2020

Accepted:

09.01.2021

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References:

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  12. Paner GP, Amin MB. Alvarado-Cabrero I, et al. A novel tumor grading scheme for chromophobe renal cell carcinoma: prognostic utility and comparison with Furman nuclear grade. The American Journal of Surgical Pathology. 2010;34(9):1233-1240. https://doi.org/10.1097/PAS.0b013e3181e96f2a
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