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Petrikov A.S.

Altai State Medical University;
Diagnostic Center of Altai Territory

Parnaparin sodium — modern therapy options and prevention of venous thromboembolic complications

Authors:

Petrikov A.S.

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Journal: Pirogov Russian Journal of Surgery. 2020;(11): 115‑126

DOI: 10.17116/hirurgia2020111115

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Table of contents

PARNAPARIN SODIUM — MODERN THERAPY OPTIONS AND PREVENTION OF VENOUS THROMBOEMBOLIC COMPLICATIONS
PARNAPARIN SODIUM — MODERN THERAPY OPTIONS AND PREVENTION OF VENOUS THROMBOEMBOLIC COMPLICATIONS

To cite this article:

Petrikov AS. Parnaparin sodium — modern therapy options and prevention of venous thromboembolic complications. Pirogov Russian Journal of Surgery. 2020;(11):115‑126. (In Russ.)
https://doi.org/10.17116/hirurgia2020111115

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Venous thromboembolic complications (VTEC) including pulmonary embolism and acute thrombosis of deep and superficial veins of the lower extremities are often observed in postoperative period. Low-molecular-weight heparin (LMWH) is a common remedy for prevention and treatment of VTEC due to high efficiency, safety, easy use and dosage. According to the modern literature data, LMWH is characterized by different effectiveness in relation to VTEC and risk of bleeding in patients after surgical and traumatological procedures, as well as in ones with severe forms of chronic venous diseases. However, their antithrombin activity varies significantly depending on mean molecular weight. The authors analyze LMWH action mechanism, pharmacokinetic and pharmacodynamic features of LMWH, in particular parnaparin sodium. Efficacy, safety and tolerability of this remedy for various forms of VTEC (superficial and deep vein thrombosis, thrombophlebitis, complicated forms of chronic venous diseases), its advantages for prevention of VTEC after various surgical and orthopedic interventions are considered.

Keywords:

deep vein thrombosis (DVT)
pulmonary embolism (PE)
superficial vein thrombosis
prevention and treatment of VTEC
low-molecular-weight heparin (LMWH)
sodium parnaparin (fluxum)

Authors:

Petrikov A.S.

Altai State Medical University;
Diagnostic Center of Altai Territory

Received:

30.07.2020

Accepted:

10.08.2020

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References:

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