Myxoma arising from the right atrium accounts for 7—18% of all these tumors. Any myxoma is characterized by classic triad of symptoms with blood flow obstruction, constitutional signs and thromboembolic phenomena. We present a rare variant of asymptomatic course of large myxoma in the right atrium in a 65-year-old man. The tumor was discovered accidentally when the patient visited the clinic due to long-term uncontrollable paroxysm of atrial fibrillation. The neoplasm was attached to anterior wall of the right atrium and did not reach tricuspid annulus. There were no symptoms of blood flow obstruction. We performed direct myocardial revascularization, resection of the right atrial tumor, ligation of the left atrial appendage and tricuspid valve annuloplasty. The tumor was a node 4.5×5 x 4.5 cm with grayish-brown tuberous surface. Histological analysis revealed myxoid tissue with confluent hemorrhages and hemorrhagic impregnation, necrosis and foci of lymphoplasmacytic infiltration. This case is of interest due to rare localization of myxoma in the right atrium and asymptomatic course of disease.