Aim — to assess the outcomes of different revascularization techniques in patients with multifocal peripheral artery disease (MPAD). Material and methods. Postoperative period was analyzed in 222 MPAD patients. They were divided into 3 groups according to the type of arterial reconstruction: 129 patients underwent open surgery, 63 — endovascular revascularization, 30 — hybrid interventions. Results. There were more patients of high perioperative risk (ASA III—IV) in groups of endovascular and hybrid procedures (p<0.05). All hybrid interventions were performed simultaneously that led to cost-effectiveness of intervention and primary 30-day patency of repaired segment. Limb loss incidence in open surgery group was 4.9%, while endovascular and hybrid surgeries were not followed by this complication within 30-days. Conclusion. Hybrid interventions minimize the risk of negative postoperative consequences. So, they may be used in those patients who have contraindications for open reconstructions.