Experimental analysis of toxicity and antiarrhythmic properties of a new class of compounds: 2-(2-(dialkylaminopolyethoxy))ethylcarboxylates

Arzamastsev EV, Kaldyrkaeva OS, Afanasieva EYu, et al. . Experimental analysis of toxicity and antiarrhythmic properties of a new class of compounds: 2-(2-(dialkylaminopolyethoxy))ethylcarboxylates. Russian Cardiology Bulletin. 2024;19(2):21‑26. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20241902121

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OBJECTIVE

To study acute toxicity and antiarrhythmic properties of 2-(2-(dialkylaminopolyethoxy))ethylcarboxylates, as well as to select the most perspective antiarrhythmic compounds.

MATERIAL AND METHODS

Screening and analysis of toxicity of compounds were performed on models of arrhythmias induced by aconitine hydrobromide, calcium chloride and barium chloride.

RESULTS

Experimental research of aconitine model of arrhythmia showed that B-29 compound had low toxicity and obvious antiarrhythmic properties.

CONCLUSION

The most active compounds of 2-(2-(dialkylaminopolyethoxy))ethylcarboxylates are substances with low toxicity and high antiarrhythmic activity. The most active substance under the conditional code B-29 is perspective for further studies and creation of new highly effective medicinal product for the treatment and prevention of cardiac arrhythmias

Keywords:

2-(2-(dialkylaminopolyethoxy))ethylcarboxylates

cardiac arrhythmias

antiarrhythmic index

mean effective dose

Authors:

Arzamastsev E.V.

Chazov National Medical Research Centre of Cardiology

ORCID: 0000-0002-1270-3067

Kaldyrkaeva O.S.

Chazov National Medical Research Centre of Cardiology

ORCID: 0000-0002-9032-9752

Afanasieva E.Yu.

Chazov National Medical Research Centre of Cardiology

ORCID: 0000-0002-5620-4649

Terekhova O.A.

Chazov National Medical Research Centre of Cardiology

ORCID: 0000-0003-4657-2672

Levitskaya E.L.

Chazov National Medical Research Centre of Cardiology

ORCID: 0000-0003-3306-2323

Kydryavtseva E.V.

Chazov National Medical Research Centre of Cardiology

ORCID: 0000-0003-1960-1693

Polyektova V.P.

Chazov National Medical Research Centre of Cardiology

ORCID: 0000-0001-5089-2105

Gaisinyuk T.V.

Chazov National Medical Research Centre of Cardiology

ORCID: 0000-0001-6981-4094

Received:

06.10.2023

Accepted:

25.03.2024

List of references:

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