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Alieva A.M.

Pirogov Russian National Research Medical University

Teplova N.V.

Pirogov Russian National Research Medical University

Reznik E.V.

Pirogov Russian National Research Medical University

Baikova I.E.

Pirogov Russian National Research Medical University

Makeeva L.M.

Pirogov Russian National Research Medical University

Kotikova I.A.

Pirogov Russian National Research Medical University

Valiev R.K.

Loginov Moscow Clinical Scientific Center

Modestova A.V.

Pirogov Russian National Research Medical University

Skripnichenko E.A.

Pirogov Russian National Research Medical University

Nikitin I.G.

Pirogov Russian National Research Medical University

Diagnostic and prognostic aspects of omentin in cardiovascular diseases

Authors:

Alieva A.M., Teplova N.V., Reznik E.V., Baikova I.E., Makeeva L.M., Kotikova I.A., Valiev R.K., Modestova A.V., Skripnichenko E.A., Nikitin I.G.

More about the authors

Journal: Russian Cardiology Bulletin. 2024;19(1): 16‑22

DOI: 10.17116/Cardiobulletin20241901116

Views: 653

Downloaded: 36

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To cite this article:

Alieva AM, Teplova NV, Reznik EV, et al. . Diagnostic and prognostic aspects of omentin in cardiovascular diseases. Russian Cardiology Bulletin. 2024;19(1):16‑22. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20241901116

Подписка 2025 (Russian Cardiology Bulletin)
 
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Cardiovascular diseases are a major factor of disability and premature death worldwide. An important objective of modern cardiology is searching for new cardiovascular biological markers. These markers can be valuable for early diagnosis of cardiovascular diseases, laboratory assessing the effectiveness of treatment and prediction of possible adverse clinical outcomes. We could use these factors for risk stratification. The purpose of this review is to analyze omentin as a new diagnostic and prognostic marker for cardiovascular diseases. Omentin-1, also known as intestinal lactoferrin receptor, endothelial lectin HL-1, galactofuranase-binding lectin or integrin-1, is a recently identified secretory protein that is selectively expressed in visceral adipose tissue. Experimental and clinical data have demonstrated the crucial role of omentin-1 in metabolism and insulin sensitivity, its anti-inflammatory, anti-atherosclerotic and cardiac protective effects. It is expected that further studies will demonstrate omentin-1 as an additional laboratory tool for diagnosis and prognosis in cardiac patients. Regulation of omentin concentration and expression by various drugs may be perspective for the treatment of cardiovascular diseases.

Keywords:

cardiovascular diseases
biological markers
omentin

Authors:

Alieva A.M.

Pirogov Russian National Research Medical University

Teplova N.V.

Pirogov Russian National Research Medical University

Reznik E.V.

Pirogov Russian National Research Medical University

Baikova I.E.

Pirogov Russian National Research Medical University

Makeeva L.M.

Pirogov Russian National Research Medical University

Kotikova I.A.

Pirogov Russian National Research Medical University

Valiev R.K.

Loginov Moscow Clinical Scientific Center

Modestova A.V.

Pirogov Russian National Research Medical University

Skripnichenko E.A.

Pirogov Russian National Research Medical University

Nikitin I.G.

Pirogov Russian National Research Medical University

Received:

25.01.2023

Accepted:

07.06.2023

List of references:

  1. Shlyakhto EV, Zvartau NE, Villevalde SV, Yakovlev AN, Soloveva AE, Alieva AS, Avdonina NG, Medvedeva EA, Fedorenko AA, Kulakov VV, Karlina VA, Endubaeva GV, Zaitsev VV, Soloviev AE. Cardiovascular risk management system: prerequisites for developing, organization principles, target groups. Russian Journal of Cardiology. 2019;(11):69-82. (In Russ.). https://doi.org/10.15829/1560-4071-2019-11-69-82
  2. GBD 2015 Risk Factors Collaborators Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990—2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388:1659-1724. https://doi.org/10.1016/S0140-6736(16)31679-8
  3. Li H, Zou J, Yu XH, Ou X, Tang C. Zinc finger E-box binding homeobox 1 and atherosclerosis: new insights and therapeutic potential. Journal of Cellular Physiology. 2021;236:4216-4230. https://doi.org/10.1002/jcp.30177
  4. Shalnova SA, Deev AD, Kapustina AV, Evstifeeva SE, Muromtseva GA, Tuaeva EM, Balanova YuA, Konstantinov VV, Kiseleva NV, Shkolnikova MA. Ischemic heart disease in persons 55 years of age and older. Prevalence and prognosis. Cardiovascular therapy and prevention. 2014;13(4):21-28. (In Russ.). https://doi.org/10.15829/1728-8800-2014-4-21-28
  5. Alieva AM, Reznik EV, Gasanova ET, Zhbanov IV, Nikitin IG. Clinical significance of determining blood biomarkers in patients with chronic heart failure. Archive of internal medicine. 2018;8(5):333-345. (In Russ.). https://doi.org/10.20514/2226-6704-2018-8-5-333-345
  6. Alieva AM, Baikova IE, Kislyakov VA, Gasanova ET, Almazova II, Pinchuk TV, Fedulayev YuN, Zhbanov IV, Perevertov VA, Kovtyukh IV, Nikitin IG, Reznik EV. Galectin-3: diagnostic and prognostic value of determination in patients with chronic heart failure. Therapeutic archive. 2019;91(9):145-149. (In Russ.). https://doi.org/10.26442/00403660.2019.09.000226
  7. Alieva AM, Pinchuk TV, Almazova II, Ettinger OA, Valiev RK, Batov MA, Nikitin IG. Clinical significance of ST2 blood biomarker determination in patients with chronic heart failure. Consilium Medicum. 2021;23(6):522-526. (In Russ.).
  8. Jung HN, Jung CH. The Role of Anti-Inflammatory Adipokines in Cardiometabolic Disorders: Moving beyond Adiponectin. International Journal of Molecular Sciences. 2021;22(24):13529. https://doi.org/10.3390/ijms222413529
  9. Askin L, Duman H, Ozyıldız A, Tanriverdi O, Turkmen S. Association between Omentin-1 and Coronary Artery Disease: Pathogenesis and Clinical Research. Current Cardiology Reviews. 2020;16(3):198-201.  https://doi.org/10.2174/1573403X16666200511085304
  10. Watanabe T, Watanabe-Kominato K, Takahashi Y, Kojima M, Watanabe R. Adipose Tissue-Derived Omentin-1 Function and Regulation. Comprehensive Physiology. 2017;7(3):765-781.  https://doi.org/10.1002/cphy.c160043
  11. Hiramatsu-Ito M, Shibata R, Ohashi K, Uemura Y, Kanemura N, Kambara T, Enomoto T, Yuasa D, Matsuo K, Ito M, Hayakawa S, Ogawa H, Otaka N, Kihara S, Murohara T, Ouchi N. Omentin attenuates atherosclerotic lesion formation in apolipoprotein E-deficient mice. Cardiovascular Research. 2016;110:107-117.  https://doi.org/10.1093/cvr/cvv282
  12. Lin X, Sun Y, Yang S, Yu M, Pan L, Yang J, Yang J, Shao Q, Liu J, Liu Y, Zhou Y, Wang Z. Omentin-1 Modulates Macrophage Function via Integrin Receptors αvβ3 and αvβ5 and Reverses Plaque Vulnerability in Animal Models of Atherosclerosis. Frontiers in Cardiovascular Medicine. 2021;8:757926. https://doi.org/10.3389/fcvm.2021.757926
  13. Watanabe K, Watanabe R, Konii H, Shirai R, Sato K, Matsuyama T-A, Ishibashi-Ueda H, Koba S, Kobayashi Y, Hirano T, Watanabe T. Counteractive effects of omentin-1 against atherogenesis. Cardiovascular Research. 2016;110:118-128.  https://doi.org/10.1093/cvr/cvw016
  14. Uemura Y, Shibata R, Kanemura N, Ohashi K, Kambara T, Hiramatsu-Ito M, Enomoto T, Yuasa D, Joki Y, Matsuo K, Ito M, Hayakawa S, Ogawa H, Murohara T, Ouchi N. Adipose-derived protein omentin prevents neointimal formation after arterial injury. The FASEB Journal. 2015;29:141-151.  https://doi.org/10.1096/fj.14-258129
  15. Xie H, Xie P-L, Wu X-P, Chen S-M, Zhou H-D, Yuan L-Q, Sheng Z-F, Tang S-Y, Luo X-H, Liao E-Y. Omentin-1 attenuates arterial calcification and bone loss in osteoprotegerin-deficient mice by inhibition of RANKL expression. Cardiovascular Research. 2011;92:296-306.  https://doi.org/10.1093/cvr/cvr200
  16. Leandro A, Queiroz M, Azul L, Seica R, Sena CM. Omentin: A novel therapeutic approach for the treatment of endothelial dysfunction in type 2 diabetes. Free Radical Biology and Medicine. 2021;162:233-242.  https://doi.org/10.1016/j.freeradbiomed.2020.10.021
  17. Yamawaki H, Tsubaki N, Mukohda M, Okada M, Hara Y. Omentin, a novel adipokine, induces vasodilation in rat isolated blood vessels. Biochemical and Biophysical Research Communications. 2010;393:668-672.  https://doi.org/10.1016/j.bbrc.2010.02.053
  18. Maruyama S, Shibata R, Kikuchi R, Izumiya Y, Rokutanda T, Araki S, Kataoka Y, Ohashi K, Daida H, Kihara S, Ogawa H, Murohara T, Ouchi N. Fat-derived Factor Omentin Stimulates Endothelial Cell Function and Ischemia-induced Revascularization via Endothelial Nitric Oxide Synthase-dependent Mechanism. Journal of Biological Chemistry. 2012;287:408-417.  https://doi.org/10.1074/jbc.M111.261818
  19. Kataoka Y, Shibata R, Ohashi K, Kambara T, Enomoto T, Uemura Y, Ogura Y, Yuasa D, Matsuo K, Nagata T, Oba T, Yasukawa H, Numaguchi Y, Sone T, Murohara T, Ouchi N. Omentin prevents myocardial ischemic injury through AMP-activated protein kinase- and Akt-dependent mechanisms. JACC: Journal of the American College of Cardiology. 2014;63(24):2722-2733. https://doi.org/10.1016/j.jacc.2014.03.032
  20. Matsuo K, Shibata R, Ohashi K, Kambara T, Uemura Y, Hiramatsu-Ito M, Enomoto T, Yuasa D, Joki Y, Ito M, Hayakawa S, Ogawa H, Kihara S, Murohara T, Ouchi N. Omentin functions to attenuate cardiac hypertrophic response. Journal of Molecular and Cellular Cardiology. 2015;79:195-202.  https://doi.org/10.1016/j.yjmcc.2014.11.019
  21. Jin Z, Xia F, Dong J, Lin T, Cai Y, Chen J, Chen X, Huang Z, Wang Q, Chen H, Zhang J. Omentin-1 attenuates glucocorticoid-induced cardiac injury by phosphorylating GSK3β. Journal of Molecular Endocrinology. 2021;66(4):273-283.  https://doi.org/10.1530/JME-20-0236
  22. Wang J, Zhuo X, Jiang Z. Omentin-1 circulating levels as predictor of heart diseases: a systematic review and meta-analysis. Revista da Associacao Medica Brasileira. 2022;68(4):542-548.  https://doi.org/10.1590/1806-9282.20211111
  23. Mitsis A, Kadoglou NPE, Lambadiari V, Alexiou S, Theodoropoulos KC, Avraamides P, Kassimis G. Prognostic role of inflammatory cytokines and novel adipokines in acute myocardial infarction: An updated and comprehensive review. Cytokine. 2022;153:155848. https://doi.org/10.1016/j.cyto.2022.155848
  24. De Souza Batista CM, Yang R-Z, Lee M-J, Glynn NM, Yu D-Z, Pray J, Ndubuizu K, Patil S, Schwartz A, Kligman M, Fried SK, Gong D-W, Shuldiner AR, Pollin TI, McLenithan JC. Omentin Plasma Levels and Gene Expression Are Decreased in Obesity. Diabetes. 2007;56:1655-1661. https://doi.org/10.2337/db06-1506
  25. Zhang Q, Zhu L, Zheng M, Fan C, Li Y, Zhang D, He Y, Yang H. Changes of serum omentin-1 levels in normal subjects, type 2 diabetes and type 2 diabetes with overweight and obesity in Chinese adults. Annales d’Endocrinologie. 2014;75:171-175.  https://doi.org/10.1016/j.ando.2014.04.013
  26. Jialal I, Devaraj S, Kaur H, Adams-Huet B, Bremer AA. Increased Chemerin and Decreased Omentin-1 in Both Adipose Tissue and Plasma in Nascent Metabolic Syndrome. The Journal of Clinical Endocrinology and Metabolism. 2013;98:E514-E517. https://doi.org/10.1210/jc.2012-3673
  27. Pena-Cano MI, Valencia-Ortega J, Morales-Avila E, Diaz-Velazquez MF, Gomez-Diaz R, Saucedo R. Omentin-1 and its relationship with inflammatory factors in maternal plasma and visceral adipose tissue of women with gestational diabetes mellitus. Journal of Endocrinological Investigation. 2022; 45: 453–462.  https://doi.org/10.1007/s40618-021-01671-9
  28. Papatheodorou S, Gelaye B, Williams MA. Association between omentin-1 and indices of glucose metabolism in early pregnancy: a pilot study. Archives of Gynecology and Obstetrics. 2022;305(3):589-596.  https://doi.org/10.1007/s00404-021-06197-2
  29. Latif AHE, Anwar S, Gautham KS, Kadurei F, Ojo RO, Hafizyar F, Haroon DM, Rakesh F, Talpur AS. Association of Plasma Omentin-1 Levels with Diabetes and Its Complications. Cureus. 2021;13:e18203. https://doi.org/10.7759/cureus.18203
  30. Biscetti F, Nardella E, Bonadia N, Angelini F, Pitocco D, Santoliquido A, Filipponi M, Landolfi R, Flex A. Association between plasma omentin-1 levels in type 2 diabetic patients and peripheral artery disease. Cardiovascular Diabetology. 2019;18:74-77.  https://doi.org/10.1186/s12933-019-0880-7
  31. Bai P, Abdullah F, Lodi M, Sarhadi M, Dilip A, Shahab S, Yasir F, Jahangir M. Association between Coronary Artery Disease and Plasma Omentin-1 Levels. Cureus. 2021;13:e17347. https://doi.org/10.7759/cureus.17347
  32. Zhong X, Zhang H-Y, Tan H, Zhou Y, Liu F-L, Chen F-Q, Shang D-Y. Association of serum omentin-1 levels with coronary artery disease. Acta Pharmacologica Sinica. 2011;32:873-878.  https://doi.org/10.1038/aps.2011.26
  33. Narumi T, Watanabe T, Kadowaki S, Kinoshita D, Yokoyama M, Honda Y, Otaki Y, Nishiyama S, Takahashi H, Arimoto T, Shishido T, Miyamoto T, Kubota I. Impact of serum omentin-1 levels on cardiac prognosis in patients with heart failure. Cardiovascular Diabetology. 2014;13:84.  https://doi.org/10.1186/1475-2840-13-84
  34. Celik M, Nar R, Nar G, Sokmen E, Gunver G. Serum omentin-1 levels in hypertensive patients. Journal of Human Hypertension. 2021;35:290-295.  https://doi.org/10.1038/s41371-020-00420-4
  35. Xu T, Zuo P, Wang Y, Gao Z, Ke K. Serum omentin-1 is a novel biomarker for predicting the functional outcome of acute ischemic stroke patients. Clinical Chemistry and Laboratory Medicine. 2018;56:350-355.  https://doi.org/10.1515/cclm-2017-0282
  36. Yang J, Gao Y. Clinical relevance of serum omentin-1 levels as a biomarker of prognosis in patients with acute cerebral infarction. Brain and Behavior. 2020;10:e01678. https://doi.org/10.1002/brb3.1678
  37. Xu T, Zuo P, Cao L, Gao Z, Ke K. Omentin-1 is Associated with Carotid Plaque Instability among Ischemic Stroke Patients. Journal of Atherosclerosis and Thrombosis. 2018;25:505-511.  https://doi.org/10.5551/jat.42135
  38. Xu T, Li Y, Su Y, Zuo P, Gao Z, Ke K. Serum omentin-1 and risk of one-year mortality in patients with ischemic stroke. Clinica Chimica Acta. 2020;505:167-171.  https://doi.org/10.1016/j.cca.2020.03.007
  39. Zhang G-H, Ye Z-H, Guan H-J, Guo M, Zhou X-X, Xu Y-Y. Impact of serum omentin-1 concentrations on functional outcome among acute intracerebral hemorrhage patients. Clinica Chimica Acta. 2020;503:169-174.  https://doi.org/10.1016/j.cca.2020.01.026
  40. Onur I, Oz F, Yildiz S, Oflaz H, Sigirci S, Elitok A, Pilten S, Karaayvaz EB, Cizgici AY, Kaya MG, Onur ST, Sahin I, Dinckal HM. Serum Omentin 1 Level Is Associated with Coronary Artery Disease and Its Severity in Postmenopausal Women. Angiology. 2014;65:896-900.  https://doi.org/10.1177/0003319713511322
  41. Zhou J-P, Tong X-Y, Zhu L-P, Luo J-M, Luo Y, Bai Y-P, Li C-C, Zhang G-G. Plasma Omentin-1 Level as a Predictor of Good Coronary Collateral Circulation. Journal of Atherosclerosis and Thrombosis. 2017;24:940-948.  https://doi.org/10.5551/jat.37440
  42. Cetin Sanlialp S, Nar G, Nar R. Relationship between circulating serum omentin-1 levels and nascent metabolic syndrome in patients with hypertension. Journal of Investigative Medicine. 2022;70(3):780-785.  https://doi.org/10.1136/jim-2021-002071
  43. Baig M, Alghalayini KW, Gazzaz ZJ, Atta H. Association of Serum Omentin-1, Chemerin, and Leptin with Acute Myocardial Infarction and its Risk Factors. Pakistan Journal of Medical Sciences. 2020;36(6):1183-1188. https://doi.org/10.12669/pjms.36.6.2372
  44. Draganova AS, Polyakova EA, Kolodina DA, Belyaeva OD, Berkovich OA, Karonova TL, Shlyakhto EV. Serum omentin-1 concentration in patients with ischemic heart disease. Translational medicine. 2019;6(6):5-13. (In Russ.). https://doi.org/10.18705/2311-4495-2019-6-6-5-13
  45. Dogdus M, Dindas F, Cekici Y, Yildirim A, Kucukosmanoglu M, Koyunsever NY, Abacioglu OO, Kilic S. Association between Circulating Omentin-1 Levels and Aortic Valve Sclerosis. Acta Cardiologica Sinica. 2022;38(5):584-590.  https://doi.org/10.6515/ACS.202209_38(5).20220314A
  46. Giovannini S, Biscetti F, Brau F, Biscotti L, Santoliquido A, Pitocco D, Bernabei R, Flex A. Sortilin/Omentin-1 ratio in peripheral artery disease: A cross-sectional study on 295 unselected elderly patients. Mechanisms of Ageing and Development. 2022;205:111677. https://doi.org/10.1016/j.mad.2022.111677
  47. Siegrist M, Heitkamp M, Braun I, Vogg N, Haller B, Langhof H, Koenig W, Halle M. Changes of omentin-1 and chemerin during 4 weeks of lifestyle intervention and 1-year follow-up in children with obesity. Clinical Nutrition. 2021;40:5648-5654. https://doi.org/10.1016/j.clnu.2021.09.042
  48. Atashak S, Stannard SR, Daraei A, Soltani M, Saeidi A, Moradi F, Laher I, Hackney AC, Zouhal H. High-intensity Interval Training Improves Lipocalin-2 and Omentin-1 Levels in Men with Obesity. International Journal of Sports Medicine. 2022;43(04):328-335.  https://doi.org/10.1055/a-1560-5401
  49. De Luis DA, Calvo SG, Gomez JJL, Izaola O, Primo D, Pacheco D, Aller R. Omentin-1 Changes following Biliopancreatic Diversion and Relationship with Cardiovascular Risk Factors. Annals of Nutrition and Metabolism. 2018;73:106-112.  https://doi.org/10.1159/000491434
  50. Alkuraishy HM, Al-Gareeb AI. New Insights into the Role of Metformin Effects on Serum Omentin-1 Levels in Acute Myocardial Infarction: Cross-Sectional Study. Emergency Medicine International. 2015;2015:283021. https://doi.org/10.1155/2015/283021
  51. Kadoglou NPE, Kassimis G, Patsourakos N, Kanonidis I, Valsami G. Omentin-1 and vaspin serum levels in patients with pre-clinical carotid atherosclerosis and the effect of statin therapy on them. Cytokine. 2021;138:155364. https://doi.org/10.1016/j.cyto.2020.155364
  52. Ouerghi N, Fradj MKB, Duclos M, Bouassida A, Feki M, Weiss K, Knechtle B. Effects of High-Intensity Interval Training on Selected Adipokines and Cardiometabolic Risk Markers in Normal-Weight and Overweight/Obese Young Males-A Pre-Post Test Trial. Biology. 2022;11(6):853.  https://doi.org/10.3390/biology11060853

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