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Sidko A.R.

National Medical Research Center of Cardiology

Krylov V.S.

Chazov National Medical Research Center of Cardiology

Akchurin R.S.

Chazov National Medical Research Centre of Cardiology

Bochkarev M.A.

Chazov National Medical Research Center of Cardiology

Galyautdinov D.M.

Chazov National Medical Research Centre of Cardiology

Composite leaflet for prosthetic venous valve. First results

Authors:

Sidko A.R., Krylov V.S., Akchurin R.S., Bochkarev M.A., Galyautdinov D.M.

More about the authors

Journal: Russian Cardiology Bulletin. 2022;17(4): 70‑75

DOI: 10.17116/Cardiobulletin20221704170

Read: 1457 times

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Table of contents

COMPOSITE LEAFLET FOR PROSTHETIC VENOUS VALVE. FIRST RESULTS
COMPOSITE LEAFLET FOR PROSTHETIC VENOUS VALVE. FIRST RESULTS

To cite this article:

Sidko AR, Krylov VS, Akchurin RS, Bochkarev MA, Galyautdinov DM. Composite leaflet for prosthetic venous valve. First results. Russian Cardiology Bulletin. 2022;17(4):70‑75. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20221704170

Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To develop the method of molding a flexible leaflet from composite material based on inert fluoropolymers, and to design a model of venous valve with leaflets for following bench tests.

MATERIAL AND METHODS

Expanded polytetrafluoroethylene, thermoplastic fluoroelastomer, braided nitinol stents and special instruments were used for the models of venous valve prosthesis. The composite was characterized in burst tests. The valve models were tested in pulsatile fluid flow. After 1.000.000 open-close cycles, we tested reflux on the valves.

RESULTS

Final composite has tensile strength of 64.8 MPa with relative elongation of 55%. The designed models of venous valve with a leaflet imitating the shape of natural one remains competent after 1.000.000 open-close cycles. Reverse fluid flow in the models was only 1.5% and 2.5%. Considering these data, we obtained a patent for invention No. 2021134596.

CONCLUSION

Our results demonstrate suitability of new technology for valve molding, as well as possibility to improve the obtained results via refining the assembly process.

Keywords:

chronic venous insufficiency
venous valve prosthesis
biomimetics
bioengineering

Authors:

Sidko A.R.

National Medical Research Center of Cardiology

Krylov V.S.

Chazov National Medical Research Center of Cardiology

Akchurin R.S.

Chazov National Medical Research Centre of Cardiology

Bochkarev M.A.

Chazov National Medical Research Center of Cardiology

Galyautdinov D.M.

Chazov National Medical Research Centre of Cardiology

Received:

23.10.2022

Accepted:

31.10.2022

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References:

  1. White GH. Chronic venous insufficiency. Vascular surgery: principles and practice. 1993;865-868. 
  2. Vedantham S, Rundback JH, Khilnani NM, Gloviczki P, Andrews RT, Sadick NS, Fan CM, Meissner MH, Comerota AJ, Hume KM, Chrisman HB. Special Communications-Development of a Research Agenda for Endovenous Treatment of Lower-extremity Venous Reflux: Proceedings from a Multidisciplinary Consensus Panel. Journal of Vascular and Interventional Radiology. 2005;16(12):1575-1579. https://doi.org/10.1097/01.rvi.0000183869.53626.69
  3. Meissner MH, Eklof B, Gloviczki P, Lohr JM, Lurie F, Robert Kistner R, Gregory Moneta G, Wakefield TW. Mapping the future: Organizational, clinical, and research priorities in venous disease. Journal of Vascular Surgery. 2007;46(suppl S):84-93.  https://doi.org/10.1016/j.jvs.2007.08.049
  4. Caggiati A, Caggiati L. Surgery of venous valve. Reviews in vascular medicine. 2013;1(1):15-23.  https://doi.org/10.1016/j.rvm.2013.02.002
  5. Pavcnik D, Uchida B, Kaufman J, Hinds M, Keller FS, Rösch J. Percutaneous management of chronic deep venous reflux: review of experimental work and early clinical experience with bioprosthetic valve. Vascular Medicine. 2008;13(1):75-84.  https://doi.org/10.1177/1358863X07083474
  6. Klyshnikov KYu. stages of development of surgical treatment for insufficiency of venous valves of lower limbs. Angiology and Vascular Surgery. 2014;20(1):109-115. (In Russ.).
  7. Ulloa JH, Glickman M. One-Year First-in-Human Success for VenoValve in Treating Patients With Severe Deep Venous Insufficiency. Vascular and Endovascular Surgery. 2022;56(3):277-283.  https://doi.org/10.1177/15385744211073730
  8. Ulloa J, Glickman M, Cifuentes S, Figueroa V. Three-year Results of the Surgical Implantation of the Bioprosthetic Valve: VenoValve, for Patients with Severe Chronic Venous Insufficiency, C5-C6 Disease. Journal of Vascular Surgery: Venous and Lymphatic Disorders. 2022;10(2):572.  https://doi.org/10.1016/j.jvsv.2021.12.061
  9. Lurie F, Kistner RL, Eklof B, Kessler D. Mechanism of venous valve closure and role of the valve in circulation: a new concept. Journal of Vascular Surgery. 2003;38(5):955-961.  https://doi.org/10.1016/S0741-5214(03)00711-0
  10. Chiu JJ, Chien S. Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives. Physiological Reviews. 2011;91(1):327-387.  https://doi.org/10.1152/physrev.00047.2009
  11. Krylov VS, Sidko AR, Akchurin RS. Development of a vein valve prosthesis for interventional restoration of valve function. Russian Cardiology Bulletin. 2022;17(2 suppl):24-25. 
  12. https://nastmash.ru/articles/detail.php?ID=595  NastMash [Internet]. Moscow (RU); Nejlon 6.6; 2022. (In Russ.).
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