Circulating regulatory T cells and blood monocytes subpopulations in diffuse coronary artery atherosclerosis. (A pilot study)

Kurbanov S.K.; Filatova A.Yu.; Arefieva T.I.; Ilyina L.N.; Vlasova E.E.; Shiryaev A.A.; Akchurin R.S.

doi:https://doi.org/10.17116/Cardiobulletin20211603128

Kurbanov S.K.

Chazov National Medical Research Centre of Cardiology

ORCID: 0000-0001-7767-1695

Filatova A.Yu.

National Medical Research Center of Cardiology

Arefieva T.I.

National Medical Research Center of Cardiology

Ilyina L.N.

National Medical Research Center of Cardiology

Vlasova E.E.

National Medical Research Center of Cardiology

RSCI AuthorID: 289380
Scopus AuthorID: 7006174730
ORCID: 0000-0003-2925-244X

Shiryaev A.A.

Chazov National Medical Research Centre of Cardiology

ORCID: 0000-0002-3325-9743

Akchurin R.S.

Chazov National Medical Research Centre of Cardiology

ORCID: 0000-0002-2105-8258

Circulating regulatory T cells and blood monocytes subpopulations in diffuse coronary artery atherosclerosis. (A pilot study)

Authors:

Kurbanov S.K., Filatova A.Yu., Arefieva T.I., Ilyina L.N., Vlasova E.E., Shiryaev A.A., Akchurin R.S.

More about the authors

Journal: Russian Cardiology Bulletin. 2021;16(3): 28‑32

DOI: 10.17116/Cardiobulletin20211603128

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To cite this article:

Kurbanov SK, Filatova AYu, Arefieva TI, Ilyina LN, Vlasova EE, Shiryaev AA, Akchurin RS. Circulating regulatory T cells and blood monocytes subpopulations in diffuse coronary artery atherosclerosis. (A pilot study). Russian Cardiology Bulletin. 2021;16(3):28‑32. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20211603128

Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)

Использование инфографики авторами научных работ

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Abstract:

OBJECTIVE

To analyze cellular immunity and morphological features of atherosclerotic coronary artery disease.

MATERIAL AND METHODS

A pilot study included 29 patients hospitalized for coronary artery bypass surgery. The first group consisted of patients with diffuse coronary artery disease (n=18), the second group — those without signs of diffuse lesion (n=11). Immunophenotyping of leukocytes and analysis of leukocyte-platelet complexes were performed using direct immunofluorescence and flow cytometry.

RESULTS

Main clinical and laboratory parameters were similar in both groups. Patients with diffuse coronary artery disease had less concentration of circulating regulatory T-cells (1.6 (1.1; 2.1) versus 2.1 (1.7; 3.1) (% of lymphocytes), respectively, p<0.05) and higher count of intermediate monocytes (34.9 (26.8; 61.8) versus 19.9 (12.3; 33.5) (1000/ml), respectively, p<0.05) compared to patients without diffuse lesions.

CONCLUSION

Diffuse coronary artery disease can be promoted by deficiency of regulatory component of immunity. High level of intermediate monocytes can reflect severity of vascular wall inflammation.

Keywords:

diffuse coronary atherosclerosis

intermediate monocytes

regulatory T-lymphocytes

Authors:

Kurbanov S.K.

Chazov National Medical Research Centre of Cardiology

ORCID: 0000-0001-7767-1695

Filatova A.Yu.

National Medical Research Center of Cardiology

Arefieva T.I.

National Medical Research Center of Cardiology

Ilyina L.N.

National Medical Research Center of Cardiology

Vlasova E.E.

National Medical Research Center of Cardiology

RSCI AuthorID: 289380
Scopus AuthorID: 7006174730
ORCID: 0000-0003-2925-244X

Shiryaev A.A.

Chazov National Medical Research Centre of Cardiology

ORCID: 0000-0002-3325-9743

Akchurin R.S.

Chazov National Medical Research Centre of Cardiology

ORCID: 0000-0002-2105-8258

Received:

24.05.2021

Accepted:

24.06.2021

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References:

Brown RA, Shantsila E, Varma C, Lip GY. Epidemiology and pathogenesis of diffuse obstructive coronary artery disease: the role of arterial stiffness, shear stress, monocyte subsets and circulating microparticles. Annals of Medicine. 2016;48(6):444-455. https://doi.org/10.1080/07853890.2016.1190861
Geovanini GR, Libby P. Atherosclerosis and inflammation: overview and updates. Clinical Science. 2018;132(12):1243-1252. https://doi.org/10.1042/CS20180306
Brown RA, Lip GYH, Varma C, Shantsila E. Impact of Mon2 monocyte-platelet aggregates on human coronary artery disease. European Journal of Clinical Investigation. 2018;48(5):e12911. https://doi.org/10.1111/eci.12911
Weber C, Shantsila E, Hristov M, Caligiuri G, Guzik T, Heine GH, Hoefer IE, Monaco C, Peter K, Rainger E, Siegbahn A, Steffens S, Wojta J, Lip GY. Role and analysis of monocyte subsets in cardiovascular disease. Joint consensus document of the European Society of Cardiology (ESC) Working Groups «Atherosclerosis & Vascular Biology» and «Thrombosis». Thrombosis and Haemostasis. 2016;116(4):626-637. https://doi.org/10.1160/TH16-02-0091
Emoto T, Sasaki N, Yamashita T, Kasahara K, Yodoi K, Sasaki Y, Matsumoto T, Mizoguchi T, Hirata K. Regulatory/effector T-cell ratio is reduced in coronary artery disease. Circulation Journal. 2014;78(12):2935-2941. https://doi.org/10.1253/circj.cj-14-0644
Miyara M, Yoshioka Y, Kitoh A, Shima T, Wing K, Niwa A, Parizot C, Taflin C, Heike T, Valeyre D, Mathian A, Nakahata T, Yamaguchi T, Nomura T, Ono M, Amoura Z, Gorochov G, Sakaguchi S. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity. 2009;30(6):899-911. https://doi.org/10.1016/j.immuni.2009.03.019
Potekhina AV, Pylaeva E, Provatorov S, Ruleva N, Masenko V, Noeva E, Krasnikova T, Arefieva T. Treg/Th17 balance in stable CAD patients with different stages of coronary atherosclerosis. Atherosclerosis. 2015;238(1):17-21. https://doi.org/10.1016/j.atherosclerosis.2014.10.088
Filatova AYu, Pylaeva EA, Potekhina AV, Osokina AK, Pogorelova OA, Tripoten MI, Balakhonova TV, Provatorov SI, Noeva EA, Klesareva EA, Afanasieva OI, Arefieva TI. Subpopulations of CD4+ T-lymphocytes as factors contributing to the progression of atherosclerosis of carotid arteries. Kardiologiia. 2017;57(4):64-71. (In Russ.).
Ridker PM, MacFadyen JG, Everett BM, Libby P, Thuren T, Glynn RJ; CANTOS Trial Group. Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial. Lancet. 2018;391(10118):319-328. https://doi.org/10.1016/S0140-6736(17)32814-3
Filatova AY, Potekhina AV, Pylaeva EA, Osokina AK, Ruleva NY, Pogorelova OA, Tripoten MI, Noeva EA, Balakhonova TV, Masenko VP, Arefieva TI. The severity of internal carotid artery stenosis is associated with the circulating Th17 level. Heliyon. 2020;6(5):e03856. https://doi.org/10.1016/j.heliyon.2020.e03856
Liu Z, Lu F, Pan H, Zhao Y, Wang S, Sun S, Li J, Hu X, Wang L. Correlation of peripheral Th17 cells and Th17-associated cytokines to the severity of carotid artery plaque and its clinical implication. Atherosclerosis. 2012;221(1):232-241. https://doi.org/10.1016/j.atherosclerosis.2011.12.026
Cheng X, Yu X, Ding YJ, Fu QQ, Xie JJ, Tang TT, Yao R, Chen Y, Liao YH. The Th17/Treg imbalance in patients with acute coronary syndrome [published correction appears in Clinical Immunology. 2009;133(3):447]. Clinical Immunology. 2008;127(1):89-97. https://doi.org/10.1016/j.clim.2008.01.009
Wigren M, Björkbacka H, Andersson L, Ljungcrantz I, Fredrikson GN, Persson M, Bryngelsson C, Hedblad B, Nilsson J. Low levels of circulating CD4+FoxP3+ T cells are associated with an increased risk for development of myocardial infarction but not for stroke. Arteriosclerosis, Thrombosis, and Vascular Biology. 2012;32(8):2000-2004. https://doi.org/10.1161/ATVBAHA.112.251579