Circulating regulatory T cells and blood monocytes subpopulations in diffuse coronary artery atherosclerosis. (A pilot study)

Kurbanov S.K.

Chazov National Medical Research Centre of Cardiology

ORCID: 0000-0001-7767-1695

Filatova A.Yu.

National Medical Research Center of Cardiology

Arefieva T.I.

National Medical Research Center of Cardiology

Ilyina L.N.

National Medical Research Center of Cardiology

Vlasova E.E.

National Medical Research Center of Cardiology

RSCI AuthorID: 289380
Scopus AuthorID: 7006174730
ORCID: 0000-0003-2925-244X

Shiryaev A.A.

Chazov National Medical Research Centre of Cardiology

ORCID: 0000-0002-3325-9743

Akchurin R.S.

Chazov National Medical Research Centre of Cardiology

ORCID: 0000-0002-2105-8258

Circulating regulatory T cells and blood monocytes subpopulations in diffuse coronary artery atherosclerosis. (A pilot study)

Authors:

Kurbanov S.K., Filatova A.Yu., Arefieva T.I., Ilyina L.N., Vlasova E.E., Shiryaev A.A., Akchurin R.S.

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Journal: Russian Cardiology Bulletin. 2021;16(3): 28‑32

DOI: 10.17116/Cardiobulletin20211603128

Downloaded: 19

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To cite this article:

Kurbanov SK, Filatova AYu, Arefieva TI, Ilyina LN, Vlasova EE, Shiryaev AA, Akchurin RS. Circulating regulatory T cells and blood monocytes subpopulations in diffuse coronary artery atherosclerosis. (A pilot study). Russian Cardiology Bulletin. 2021;16(3):28‑32. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20211603128

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OBJECTIVE

To analyze cellular immunity and morphological features of atherosclerotic coronary artery disease.

MATERIAL AND METHODS

A pilot study included 29 patients hospitalized for coronary artery bypass surgery. The first group consisted of patients with diffuse coronary artery disease (n=18), the second group — those without signs of diffuse lesion (n=11). Immunophenotyping of leukocytes and analysis of leukocyte-platelet complexes were performed using direct immunofluorescence and flow cytometry.

RESULTS

Main clinical and laboratory parameters were similar in both groups. Patients with diffuse coronary artery disease had less concentration of circulating regulatory T-cells (1.6 (1.1; 2.1) versus 2.1 (1.7; 3.1) (% of lymphocytes), respectively, p<0.05) and higher count of intermediate monocytes (34.9 (26.8; 61.8) versus 19.9 (12.3; 33.5) (1000/ml), respectively, p<0.05) compared to patients without diffuse lesions.

CONCLUSION

Diffuse coronary artery disease can be promoted by deficiency of regulatory component of immunity. High level of intermediate monocytes can reflect severity of vascular wall inflammation.

Keywords:

diffuse coronary atherosclerosis

intermediate monocytes

regulatory T-lymphocytes

Authors:

Kurbanov S.K.

Chazov National Medical Research Centre of Cardiology

ORCID: 0000-0001-7767-1695

Filatova A.Yu.

National Medical Research Center of Cardiology

Arefieva T.I.

National Medical Research Center of Cardiology

Ilyina L.N.

National Medical Research Center of Cardiology

Vlasova E.E.

National Medical Research Center of Cardiology

RSCI AuthorID: 289380
Scopus AuthorID: 7006174730
ORCID: 0000-0003-2925-244X

Shiryaev A.A.

Chazov National Medical Research Centre of Cardiology

ORCID: 0000-0002-3325-9743

Akchurin R.S.

Chazov National Medical Research Centre of Cardiology

ORCID: 0000-0002-2105-8258

Received:

24.05.2021

Accepted:

24.06.2021

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