Aim.  The objective of the present study was to evaluate the long-term results of the formation of the single-cusp valve in the common femoral vein (CFV) of the patients presenting with avalvular deep veins (ADV) of the lower extremities. Material and methods. A  total of 28 patients (20 women and 8 men) at the age varying from 42 to 58 years were given surgical treatment during the period from 2008 to 2012. Six patients presented with primary ADV while in the remaining 22 ADV was  a consequence of  the post-thrombotic lesion in the valves with the complete recanalization and manifested deep venous axial reflux. In terms of the CEAP classification, the patients were categorized into the following groups: C4b (n=8), C5 (n=16), C6 (n=4). All the patents underwent ultrasonic duplex scanning (USDS) with the use of a VIVID-7 ultrasound machine (GE, USA). Twelve patients were additionally examined by retrograde phlebography. Kistner grade III—IV reflux was diagnosed in all the patients included in the study. Twenty two patients had undergone surgical interventions on  superficial and performant veins before inclusion in the study. The severe (C4b—C6) forms of chronic venous disease with manifested axial reflux in deep veins were regarded as an indication for the surgical operation in the patients refractory to traditional and conservative treatment. The method described by J. Opie was employed to construct the single-cusp venous valve in the common femoral vein. Results. The long-term results of the treatment were evaluated in 16 patients followed up during the period from 18 to 36 (mean 26.3±6.4) months. The clinical improvement was documented in 14 (87.5%) of them including three subjects with persistent healing of the ulcers and 9 showing reduced severity and  area of trophic changes in the crural soft tissues. USDS demonstrated the functional ability of the newly-formed valves and elimination of pathological venous reflux in 12 (75%) patients. The evaluation based on the VCSS scale revealed the reduction in the severity of the manifestations of chronic venous insufficiency (p<0,05). Moreover, the quality of life was improved ), its index decreased from 60,6±18,7 to 40,7±12,8 (p<0,05). The malleolar volume decreased from 271,1±4,7 to 231,5±5,7 mm (p<0,001). Conclusion. Formation of the single-cusp valve in CFV makes it possible to  eliminate pathological blood reflux from the inferior vena cava to  deep veins of the lower extremities that is known to play the main role in the evolvement and progress of chronic venous insufficiency. The high effectiveness of this operation is confirmed by the well apparent clinical improvement in the state of the affected lower extremity and the quality of life of the patients.