The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 101-59-87
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Danilevskaya O.V.

Pulmonology Scientific Research Institute;
Federal Research Clinical Center

Averyanov A.V.

Pulmonology Scientific Research Institute;
Federal Research Clinical Center

Chernyayev A.L.

Research Institute of Pulmonology;
Research Institute of Human Morphology;
Russian National Research Medical University named after N.I. Pirogov

Samsonova M.V.

Research Institute of Pulmonology

Cryotechnology in endoscopic diagnostics and treatment of respiratory diseases. What do you need to get started?

Authors:

Danilevskaya O.V., Averyanov A.V., Chernyayev A.L., Samsonova M.V.

More about the authors

Journal: Endoscopic Surgery. 2021;27(6): 23‑29

DOI: 10.17116/endoskop20212706123

Views: 3079

Downloaded: 78

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Danilevskaya OV, Averyanov AV, Chernyayev AL, Samsonova MV. Cryotechnology in endoscopic diagnostics and treatment of respiratory diseases. What do you need to get started?. Endoscopic Surgery. 2021;27(6):23‑29. (In Russ.)
https://doi.org/10.17116/endoskop20212706123

Подписка 2025 (Endoscopic Surgery)
МСФ на ЯМ
Close metadata

OBJECTIVE

Coverage of the main potential of the method of cryobiopsy, cryotherapy, etc. on the example of the authors’ own experience with the analysis of modern data from foreign researchers.

MATERIAL AND METHODS

For the period from 2018 to 2021 in 2Federal Research Clinical Center, Moscow, Russia, cryobiopsy was performed in 167 patients, including transbronchial cryobiopsy — 32, cryodestruction of benign and malignant neoplasms of the trachea and bronchi — in 19 patients, cryotherapy was performed in 17 patients, cryoextraction of bronchoblockers, foreign bodies, etc. — in 17. 3 patients underwent transbronchial cryobiopsy of the intrathoracic lymph nodes through the puncture hole. The basic principles of the performing the procedures with clear recommendations for practical use are described.

RESULTS

In 166 patients, the diagnosis was histologically verified as a result of cryobiopsy, 1 patient underwent second cryobiopsy. With transbronchial cryobiopsy, limited pneumothorax developed in 18.8% of cases. Serious bleeding was found in 9.3% of patients, followed by an ICU stay for 2—3 days. No lethal outcomes were observed.

CONCLUSION

The cryotechnology method is rather safe, very convenient, versatile, multifunctional, in general, simple to implement, and allows solving a large number of various tasks in bronchology.

Keywords:

cryobiopsy
cryodestruction
cryotherapy
transbronchial biopsy
diagnostics
lung diseases
treatment
benign and malignant tumors of respiratory tract

Authors:

Danilevskaya O.V.

Pulmonology Scientific Research Institute;
Federal Research Clinical Center

Averyanov A.V.

Pulmonology Scientific Research Institute;
Federal Research Clinical Center

Chernyayev A.L.

Research Institute of Pulmonology;
Research Institute of Human Morphology;
Russian National Research Medical University named after N.I. Pirogov

Samsonova M.V.

Research Institute of Pulmonology

Received:

09.09.2021

Accepted:

13.09.2021

List of references:

  1. Hetzel M, Hetzel J, Schumann C, Marx N, Babiak A. Cryorecanalization: a new approach for the immediate management of acute airway obstruction. J Thorac Cardiovasc Surg. 2004;127(5):1427-1431. https://doi.org/10.1016/j.jtcvs.2003.12.032
  2. Franke KJ, Szyrach M, Nilius G, Hetzel J, Hetzel M, Ruehle KH, Enderle MD. Experimental study on biopsy sampling using new flexible cryoprobes: influence of activationtime, probe size, tissue consistency, and contact pressure of the probe on the size of the biopsy specimen. Lung. 2009;187(4):253-259.  https://doi.org/10.1007/s00408-009-9156-4
  3. Hetzel J, Eberhardt R, Herth FJ, Petermann C, Reichle G, Freitag L, Dobbertin I, Franke KJ, Stanzel F, Beyer T, Möller P, Fritz P, Ott G, Schnabel PA, Kastendieck H, Lang W, Morresi-Hauf AT, Szyrach MN, Muche R, Shah PL, Babiak A, Hetzel M. Cryobiopsy increases the diagnostic yield of endobronchial biopsy: a multicentre trial. Eur Respir J. 2012;39(3):685-690.  https://doi.org/10.1183/09031936.00033011
  4. DiBardino DM, Lanfranco AR, Haas AR. Bronchoscopic Cryotherapy. Clinical applications of the cryoprobe, cryospray, and cryoadhesion. Ann Am Thorac Soc. 2016;13:1405-1415. https://doi.org/10.1513/AnnalsATS.201601-062FR
  5. Troy LK, Grainge C, Corte TJ, Williamson JP, Vallely MP. Diagnostic accuracy of transbronchial lung cryobiopsy for interstitial lung disease diagnosis (COLDICE): a prospective, comparative study. Lancet Respir Med. 2020;8(2):171-181.  https://doi.org/10.1016/S2213-2600(19)30342-X
  6. Ganganah O, Guo SL, Chiniah M, Li YS. Efficacy and safety of cryobiopsy versus forceps biopsy for interstitial lung diseases and lung tumours: A systematic review and meta-analysis. Respirology. 2016;21(5):834-841.  https://doi.org/10.1111/resp.12770
  7. Hetzel J, Eberhardt R, Petermann C, Gesierich W, Darwiche K. Bleeding risk of transbronchial cryobiopsy compared to transbronchialforceps biopsy in interstitial lung disease — a prospective, randomized, multicentre cross-over trial. Respir Res. 2019;20(1):140.  https://doi.org/10.1186/s12931-019-1091-1
  8. Du Rand IA, Barber PV, Goldring J. British Thoracic Society guideline for advanced diagnostic and therapeutic flexible bronchoscopy in adults. Thorax. 2011;66:1-21.  https://doi.org/10.1136/thoraxjnl-2011-200713
  9. Segmen F, Aktaş Z, Öztürk A, Kızılgöz D, Yılmaz A, Alıcı IO, Demirağ F, Pehlivanoğlu P. How many samples would be optimal for endobronchial cryobiopsy? Surg Endosc. 2017;31(3):1219-1224. https://doi.org/10.1007/s00464-016-5095-3
  10. Haentschel M, Boeckeler M, Ehab A, Wagner R, Spengler W, Steger V, Boesmueller H, Horger M, Lewis RA, Fend F, Kanz L, Bonzheim I, Hetzel J. Cryobiopsy increases the EGFR detection rate in non-small cell lung cancer. Lung Cancer. 2020;141:56-63.  https://doi.org/10.1016/j.lungcan.2019.12.008
  11. Hetzel J, Eberhardt R, Herth FJ. Cryobiopsy increases the diagnostic yield of endobronchial biopsy: a multicentre trial. Eur Respir J. 2012;39(3):685-690.  https://doi.org/10.1183/09031936.00033011
  12. Jabari H, Sami R, Fakhri M, Kaini A. Different protocols for cryobiopsy versus forceps biopsy in diagnosis of patients with endobronchial tumors. Pneumologia. 2012;61(4):230-233. 
  13. Mehrad M, Colby TV, Giulio Rossi G, Cavazza A. Transbronchial cryobiopsy in the diagnosis of fibrotic interstitial lung disease. Arch Pathol Lab Med. 2020;144(12):1501-1508. https://doi.org/10.5858/arpa.2020-0007-RA
  14. Hetzel J, Maldonado F, Ravaglia C, Wells AU, Colby TV. Transbronchial Cryobiopsies for the Diagnosis of Diffuse Parenchymal Lung Diseases: Expert Statement from the Cryobiopsy Working Group on Safety and Utility and a Call for Standardization of the Procedure. Respiration. 2018;95(3):188-200.  https://doi.org/10.1159/000484055
  15. Bendstrup E, Kronborg-White S, Madsen LB, Rasmussen TR, Folkersen B, et al. Surgical Lung biopsy and Cryobiopsy in Fibrosing Interstitial Lung Diseases: One Swallow Does Not Make a Summer. Am J Respir Crit Care Med. 2019;200(7):939-940.  https://doi.org/10.1164/rccm.201904-0744LE
  16. Ravaglia C, Wells AU, Tomassetti S. Diagnostic yield and risk/benefit analysis of transbronchial lung cryobiopsy in diffuse parenchymal lung diseases: a large cohort of 699 patients. BMC Pulm Med. 2019;19(1):16.  https://doi.org/10.1186/s12890-019-0780-3
  17. Linhas R, Marçôa R, Oliveira A, Almeida J, Neves S, Campainha S. Transbronchial lung cryobiopsy: associated complications. Rev Port Pneumol. (2006). 2017;23(6):331-337.  https://doi.org/10.1016/j.rppnen.2017.07.001
  18. Ravaglia C, Bonifazi M, Wells AU, Tomassetti S, Gurioli C, Piciucchi S, et al. Safety and diagnostic yield of transbronchial lung cryobiopsy in diffuse parenchymal lung diseases: a comparative study versus video-assisted thoracoscopic lung biopsy and a systematic review of the literature. Respiration. 2016;91:215-27.  https://doi.org/10.1159/000444089
  19. Almeida LM, Lima B, Mota PC, Melo N, Magalhães A, Pereira JM, Moura CS, Guimarães S, Morais A. Learning curve for transbronchial lung cryobiopsy in diffuse lung disease. Rev Port Pneumol (2006). 2017;S2173-5115(17)30148-3.  https://doi.org/10.1016/j.rppnen.2017.09.005
  20. Oki M, Saka H, Sako C. Bronchoscopic miniforceps biopsy for mediastinal nodes. J Bronchology. 2004;11:150-153.  https://doi.org/10.1097/01.lab.0000131025.97382.4c
  21. Shiari A, Aljundi L, Zein R. Comparing the efficiency of endobronchial ultrasound with the use of microscopic forceps vs fine needle aspiration. Chest. 2019;155:263A. https://doi.org/10.1016/j.chest.2019.02.255
  22. Arno J. On the mode of applyingcold elicicntly in diseases of the uterus. Med Tues Gazett. 1857;14:307-308. 
  23. Maiwand M.O. Cryotherapy for advanced carcinoma of the trachea and bronchi. Br Med J. 1986;293:181-182. 
  24. Niu L, Xu K, Mu F. Cryosurgery for lung cancer. J Thorac Dis. 2012;4(4):408-419.  https://doi.org/10.3978/j.issn.2072-1439.2012.07.13.
  25. Krimsky WS, Rodrigues MP, Malayaman N. Spray cryotherapy for the treatment of glottis and subglottic stenosis. Laryngoscope. 2010;120:473-477.  https://doi.org/10.1002/lary.20794
  26. Browning R, Turner JF, Parrish S. Spray cryotherapy (SCT): institutional evolution of techniques and clinical practice from early experience in the treatment of malignant airway disease. J Thorac Dis. 2015;7:S405-414.  https://doi.org/10.3978/j.issn.2072-1439.2015.12.07

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register


We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.