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Kuznetsova I.A.

Pavlov First Saint Petersburg State Medical University

Rybakova M.G.

Pavlov First Saint Petersburg State Medical University

Dvorakovskaya I.V.

Pavlov First Saint Petersburg State Medical University

Tikhonova Yu.A.

Pavlov First Saint Petersburg State Medical University

Markusevich E.V.

Pavlov First Saint Petersburg State Medical University

Danilova D.M.

Pavlov First Saint Petersburg State Medical University

Clinical and morphological characteristics of lung sequestration

Authors:

Kuznetsova I.A., Rybakova M.G., Dvorakovskaya I.V., Tikhonova Yu.A., Markusevich E.V., Danilova D.M.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2024;86(5): 15‑20

DOI: 10.17116/patol20248605115

Views: 460

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Table of contents

To cite this article:

Kuznetsova IA, Rybakova MG, Dvorakovskaya IV, Tikhonova YuA, Markusevich EV, Danilova DM. Clinical and morphological characteristics of lung sequestration. Russian Journal of Archive of Pathology. 2024;86(5):15‑20. (In Russ.)
https://doi.org/10.17116/patol20248605115

Подписка 2025 (Russian Journal of Archive of Pathology)
МСФ на ЯМ
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OBJECTIVE

To study the clinical and morphological manifestations of lung sequestration.

MATERIAL AND METHODS

Surgical material (lung tissue) of 18 patients (2017—2021) and 8 archival observations (1972—1994) of confirmed lung sequestration were examined. Histological staining (hematoxylin and eosin, Schiff reagent, Ziehl-Neelsen, picrofuchsin according to Van Gieson) and immunohistochemical reactions with antibodies to SMA, TTF1, CK5/6 (DAKO) were performed.

RESULTS

The ratio of men to women was 5:4; the average age of the patients was 35 years. Lung sequestration is localized mainly in the lower lobe segments, the left lung is involved in the pathological process more often. The cystic variant of lung sequestration with a chronic inflammatory process prevailed. Histological examination revealed the similarity of lung sequestration with congenital adenomatous lung malformation type 2 and rhabdomyomatous dysplasia. The respiratory and bronchial epithelium lost differentiation in the sequestered area.

CONCLUSION

The morphological picture of lung sequestration is nonspecific and can manifest itself in various types of inflammatory reactions and remodeling of lung tissue.

Keywords:

congenital malformations
lung sequestration
pathological anatomy

Authors:

Kuznetsova I.A.

Pavlov First Saint Petersburg State Medical University

Rybakova M.G.

Pavlov First Saint Petersburg State Medical University

Dvorakovskaya I.V.

Pavlov First Saint Petersburg State Medical University

Tikhonova Yu.A.

Pavlov First Saint Petersburg State Medical University

Markusevich E.V.

Pavlov First Saint Petersburg State Medical University

Danilova D.M.

Pavlov First Saint Petersburg State Medical University

Received:

05.06.2024

Accepted:

26.06.2024

List of references:

  1. Vinokurov AS, Smirnova AD, Belen’kaya OI, Yudin AL. An actual concept of pulmonary sequestration. Medical Visualization. 2024;28(1):88-96. (In Russ.). https://doi.org/10.24835/1607-0763-1328
  2. Pryce DM. Lower accessory pulmonary artery with intralobar sequestration of lung: a report of seven cases. J Pathol Bacteriol. 1946;58(3):457-467.  https://doi.org/10.1002/path.1700580316
  3. Sade RM, Clouse M, Ellis FH Jr. The spectrum of pulmonary sequestration. Ann Thorac Surg. 1974;18(6):644-658.  https://doi.org/10.1016/s0003-4975(10)64417-7
  4. Ren S, Yang L, Xiao Y, Tong Z, Wang L, Hu Y. Pulmonary sequestration in adult patients: a single-center retrospective study. Respir Res. 2023;24(1):13.  https://doi.org/10.1186/s12931-023-02320-w
  5. Novikova IV, Venchikova NA, Solov’eva IV, Kovalev SI, Tarletskaya OA, Tomasheva VA, Marakhovskaya EI. Sekvestratsiya legkikh: anatomicheskie varianty, soputstvuyushchie anomalii, i assotsiatsiya s kistozno-adenomatoznym porokom razvitiya II tipa. Prenatal’naya Diagnostika. 2016;15(3):219-226. (In Russ.).
  6. Sun X, Xiao Y. Pulmonary sequestration in adult patients: a retrospective study. Eur J Cardiothorac Surg. 2015;48(2):279-282.  https://doi.org/10.1093/ejcts/ezu397
  7. Cunha SA, Klepetko W. Intrapulmonary lung sequestration. Port J Card Thorac Vasc Surg. 2022;29(3):85.  https://doi.org/10.48729/pjctvs.282
  8. Wei Y, Li F. Pulmonary sequestration: a retrospective analysis of 2625 cases in China. Eur J Cardiothorac Surg. 2011;40(1):e39-e42.  https://doi.org/10.1016/j.ejcts.2011.01.080
  9. Zhang N, Zeng Q, Chen C, Yu J, Zhang X. Distribution, diagnosis, and treatment of pulmonary sequestration: report of 208 cases. J Pediatr Surg. 2019;54(7):1286-1292. https://doi.org/10.1016/j.jpedsurg.2018.08.054
  10. Gabelloni M, Faggioni L, Accogli S, Aringhieri G, Neri E. Pulmonary sequestration: what the radiologist should know. Clin Imaging. 2021;73:61-72.  https://doi.org/10.1016/j.clinimag.2020.11.040
  11. Hertzog P, Roujeau J, Marcou J. Epidermoid cancer developed on a sequestration. J Fr Med Chir Thorac 1963;17:33-38. (In French).
  12. Salvati F. Anomalie cardiovascolari, bronco-parenchimali e neoplastiche connesse con la sequestrazione polmonare: rassegna critica Cardiovascular, broncho-parenchimal and neoplastic anomalies related to pulmonary sequestration: a critical review. Recenti Prog Med. 2018;109(7):388-392. (In Italian). https://doi.org/10.1701/2955.29708

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