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Drobintseva A.O.

Saint Petersburg State Pediatric Medical University;
Saint Petersburg Research Institute of Phthisiopulmonology

Mironova E.S.

Saint Petersburg Research Institute of Phthisiopulmonology;
Saint Petersburg Institute of Bioregulation and Gerontology

Zubareva T.S.

Saint Petersburg Research Institute of Phthisiopulmonology;
Saint Petersburg Institute of Bioregulation and Gerontology

Krylova Yu.S.

Saint Petersburg Research Institute of Phthisiopulmonology;
First Saint Petersburg State Medical University named after. acad. I.P. Pavlov (Pavlov University)

Kvetnoy I.M.

St. Petersburg Research Institute of Phthisiopulmonology;
St. Petersburg State University

Paltsev M.A.

Lomonosov Moscow State University

Yablonskiy P.K.

St. Petersburg Research Institute of Phthisiopulmonology;
St. Petersburg State University

Modern approaches to studying the molecular mechanisms of lung functioning in normal and pathological conditions

Authors:

Drobintseva A.O., Mironova E.S., Zubareva T.S., Krylova Yu.S., Kvetnoy I.M., Paltsev M.A., Yablonskiy P.K.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2024;86(2): 58‑64

DOI: 10.17116/patol20248602158

Views: 705

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Table of contents

To cite this article:

Drobintseva AO, Mironova ES, Zubareva TS, Krylova YuS, Kvetnoy IM, Paltsev MA, Yablonskiy PK. Modern approaches to studying the molecular mechanisms of lung functioning in normal and pathological conditions. Russian Journal of Archive of Pathology. 2024;86(2):58‑64. (In Russ.)
https://doi.org/10.17116/patol20248602158

Подписка 2025 (Russian Journal of Archive of Pathology)
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Problems with breathing and lung function are caused by the development of various lung diseases associated with lifestyle, harmful environmental factors and genetic predisposition. Knowledge of the molecular mechanisms of the development of the pathological process will allow on time identification of the disease or the development of targeted therapy. The article provides an overview of modern methods that make it possible to most accurately reproduce the structural, functional and mechanical properties of the lung (organ-on-a-chip), to perform non-invasive molecular studies of biomarkers of bronchopulmonary pathology using saliva diagnostics, as well as using DNA and RNA aptamers, verify tumor markers in biological samples of human tissue. Analysis of alterations in the pattern of protein glycosylation using glycodiagnostic methods makes it possible to detect lung cancer in the early stages.

Keywords:

lung diseases
signaling molecules
saliva diagnostics
DNA aptamer
glycodiagnostics

Authors:

Drobintseva A.O.

Saint Petersburg State Pediatric Medical University;
Saint Petersburg Research Institute of Phthisiopulmonology

Mironova E.S.

Saint Petersburg Research Institute of Phthisiopulmonology;
Saint Petersburg Institute of Bioregulation and Gerontology

Zubareva T.S.

Saint Petersburg Research Institute of Phthisiopulmonology;
Saint Petersburg Institute of Bioregulation and Gerontology

Krylova Yu.S.

Saint Petersburg Research Institute of Phthisiopulmonology;
First Saint Petersburg State Medical University named after. acad. I.P. Pavlov (Pavlov University)

Kvetnoy I.M.

St. Petersburg Research Institute of Phthisiopulmonology;
St. Petersburg State University

Paltsev M.A.

Lomonosov Moscow State University

Yablonskiy P.K.

St. Petersburg Research Institute of Phthisiopulmonology;
St. Petersburg State University

Received:

30.08.2023

Accepted:

18.10.2023

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