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Baram D.V.

Russian Research Institute of Hematology and Transfusiology

Asaulenko Z.P.

North-Western State Medical University named after I.I. Mechnikov;
St. Petersburg City Hospital No 40

Spiridonov I.N.

St. Petersburg City Hospital No 40

Krivolapov Yu.A.

North-Western State Medical University named after I.I. Mechnikov

WHO classification of tumors of hematopoietic and lymphoid tissues, 2022 (5th edition): lymphoid tumors

Authors:

Baram D.V., Asaulenko Z.P., Spiridonov I.N., Krivolapov Yu.A.

More about the authors

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To cite this article:

Baram DV, Asaulenko ZP, Spiridonov IN, Krivolapov YuA. WHO classification of tumors of hematopoietic and lymphoid tissues, 2022 (5th edition): lymphoid tumors. Russian Journal of Archive of Pathology. 2023;85(4):24‑31. (In Russ.)
https://doi.org/10.17116/patol20238504124

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References:

  1. WHO Classification of Tumours Editorial Board. Haematolymphoid tumours. WHO classification of tumours series. 5th ed. Vol. 11. France, Lyon: International Agency for Research on Cancer; 2022. https://tumourclassification.iarc.who.int/chapters/63
  2. Zaliova M, Kotrova M, Bresolin S, Stuchly J, Stary J, Hrusak O, Te Kronnie G, Trka J, Zuna J, Vaskova M. ETV6/RUNX1-like acute lymphoblastic leukemia: a novel B-cell precursor leukemia subtype associated with the CD27/CD44 immunophenotype. Genes Chromosomes Cancer. 2017;56(8):608-616.  https://doi.org/10.1002/gcc.22464
  3. Jeha S, Choi J, Roberts KG, Pei D, Coustan-Smith E, Inaba H, Rubnitz JE, Ribeiro RC, Gruber TA, Raimondi SC, et al. Clinical significance of novel subtypes of acute lymphoblastic leukemia in the context of minimal residual disease-directed therapy. Blood Cancer Discov. 2021;2(4):326-337.  https://doi.org/10.1158/2643-3230.BCD-20-0229
  4. Fischer U, Forster M, Rinaldi A, Risch T, Sungalee S, Warnatz HJ, Bornhauser B, Gombert M, Kratsch C, Stütz AM, et al. Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options. Nat Genet. 2015;47(9):1020-1029. https://doi.org/10.1038/ng.3362
  5. Mouttet B, Vinti L, Ancliff P, Bodmer N, Brethon B, Cario G, Chen-Santel C, Elitzur S, Hazar V, Kunz J, et al. Durable remissions in TCF3-HLF positive acute lymphoblastic leukemia with blinatumomab and stem cell transplantation. Haematologica. 2019;104(6):244-247.  https://doi.org/10.3324/haematol.2018.210104
  6. Caligaris-Cappio F, Ghia P. Novel insights in chronic lymphocytic leukemia: are we getting closer to understanding the pathogenesis of the disease? J Clin Oncol. 2008;26(27):4497-4503. https://doi.org/10.1200/JCO.2007.15.4393
  7. Giné E, Martinez A, Villamor N, López-Guillermo A, Camos M, Martinez D, Esteve J, Calvo X, Muntañola A, Abrisqueta P, et al. Expanded and highly active proliferation centers identify a histological subtype of chronic lymphocytic leukemia («accelerated» chronic lymphocytic leukemia) with aggressive clinical behavior. Haematologica. 2010;95(9):1526-1533. https://doi.org/10.3324/haematol.2010.022277
  8. Enno A, Catovsky D, O’Brien M, Cherchi M, Kumaran TO, Galton DA. ‘Prolymphocytoid’ transformation of chronic lymphocytic leukaemia. Br J Haematol. 1979;41(1):9-18.  https://doi.org/10.1111/j.1365-2141.1979.tb03676.x
  9. Melo JV, Catovsky D, Galton DA. The relationship between chronic lymphocytic leukaemia and prolymphocytic leukaemia. II. Patterns of evolution of ‘prolymphocytoid’ transformation. Br J Haematol. 1986;64(1):77-86.  https://doi.org/10.1111/j.1365-2141.1986.tb07575.x
  10. van den Brand M, Rijntjes J, Hebeda KM, Menting L, Bregitha CV, Stevens WB, van der Velden WJ, Tops BB, van Krieken JH, Groenen PJ. Recurrent mutations in genes involved in nuclear factor-κB signalling in nodal marginal zone lymphoma-diagnostic and therapeutic implications. Histopathology. 2017;70(2):174-184.  https://doi.org/10.1111/his.13015
  11. Bonfiglio F, Bruscaggin A, Guidetti F, Terzi di Bergamo L, Faderl M, Spina V, Condoluci A, Bonomini L, Forestieri G, Koch R, et al. Genetic and phenotypic attributes of splenic marginal zone lymphoma. Blood. 2022;139(5):732-747.  https://doi.org/10.1182/blood.2021012386
  12. Willemze R, Cerroni L, Kempf W, Berti E, Facchetti F, Swerdlow SH, Jaffe ES. The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas. Blood. 2019;133(16):1703-1714. https://doi.org/10.1182/blood-2018-11-881268
  13. Bachy E, Seymour JF, Feugier P, Offner F, López-Guillermo A, Belada D, Xerri L, Catalano JV, Brice P, Lemonnier F, et al. Sustained progression-free survival benefit of rituximab maintenance in patients with follicular lymphoma: long-term results of the PRIMA study. J Clin Oncol. 2019;37(31):2815-2824. https://doi.org/10.1200/JCO.19.01073
  14. Busquets O, Ettcheto M, Pallàs M, Beas-Zarate C, Verdaguer E, Auladell C, Folch J, Camins A. Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6J mice. A potential model of sporadic Alzheimer’s disease. Mech Ageing Dev. 2017;162:38-45.  https://doi.org/10.1016/j.mad.2016.11.002
  15. Laurent C, Adélaïde J, Guille A, Tesson B, Gat E, Evrard S, Escudié F, Syrykh C, Canioni D, Fabiani B, et al.; Lymphoma Study Association (LYSA). High-grade follicular lymphomas exhibit clinicopathologic, cytogenetic, and molecular diversity extending beyond grades 3A and 3B. Am J Surg Pathol. 2021;45(10):1324-1336. https://doi.org/10.1097/PAS.0000000000001726
  16. Nann D, Ramis-Zaldivar JE, Müller I, Gonzalez-Farre B, Schmidt J, Egan C, Salmeron-Villalobos J, Clot G, Mattern S, Otto F, et al. Follicular lymphoma t(14;18)-negative is genetically a heterogeneous disease. Blood Adv. 2020;4(22):5652-5665. https://doi.org/10.1182/bloodadvances.2020002944
  17. Koch K, Richter J, Hanel C, Huttmann A, Duhrsen U, Klapper W. Follicular lymphoma grade 3B and diffuse large B-cell lymphoma present a histopathological and molecular continuum lacking features of progression/ transformation. Haematologica. 2022;107(9):2144-2153. https://doi.org/10.3324/haematol.2021.279351
  18. Salaverria I, Martin-Guerrero I, Wagener R, Kreuz M, Kohler CW, Richter J, Pienkowska-Grela B, Adam P, Burkhardt B, Claviez A, et al.; Molecular Mechanisms in Malignant Lymphoma Network Project; Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group. A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma. Blood. 2014;123(8):1187-1198. https://doi.org/10.1182/blood-2013-06-507996
  19. Fend F, Ferreri AJ, Coupland SE. How we diagnose and treat vitreoretinal lymphoma [published correction appears in Br J Haematol. 2018;181(5):712]. Br J Haematol. 2016;173(5):680-692.  https://doi.org/10.1111/bjh.14025
  20. Johnson SM, Umakanthan JM, Yuan J, Fedoriw Y, Bociek RG, Kaiser-Rogers K, Sanmann JN, Montgomery ND. Lymphomas with pseudo-double-hit BCL6-MYC translocations due to t(3;8)(q27;q24) are associated with a germinal center immunophenotype, extranodal involvement, and frequent BCL2 translocations. Hum Pathol. 2018;80:192-200.  https://doi.org/10.1016/j.humpath.2018.06.006
  21. Fermand JP, Bridoux F, Kyle RA, Kastritis E, Weiss BM, Cook MA, Drayson MT, Dispenzieri A, Leung N; International Kidney and Monoclonal Gammopathy Research Group. How I treat monoclonal gammopathy of renal significance (MGRS). Blood. 2013;122(22):3583-3590. https://doi.org/10.1182/blood-2013-05-495929
  22. Bylsma LC, Gulbech Ording A, Rosenthal A, Öztürk B, Fryzek JP, Arias JM, Röth A, Berentsen S. Occurrence, thromboembolic risk, and mortality in Danish patients with cold agglutinin disease. Blood Adv. 2019;3(20):2980-2985. https://doi.org/10.1182/bloodadvances.2019000476
  23. Marcus A, Sadimin E, Richardson M, Goodell L, Fyfe B. Fluorescence microscopy is superior to polarized microscopy for detecting amyloid deposits in Congo red-stained trephine bone marrow biopsy specimens. Am J Clin Pathol. 2012;138(4):590-593.  https://doi.org/10.1309/AJCP6HZI5DDQTCRM
  24. Vrana JA, Gamez JD, Madden BJ, Theis JD, Bergen HR 3rd, Dogan A. Classification of amyloidosis by laser microdissection and mass spectrometry-based proteomic analysis in clinical biopsy specimens. Blood. 2009;114(24):4957-4959. https://doi.org/10.1182/blood-2009-07-230722
  25. Farooq U, Choudhary S, McLeod MP, Torchia D, Rongioletti F, Romanelli P. Adenopathy and extensive skin patch overlying a plasmacytoma (AESOP) syndrome. J Clin Aesthet Dermatol. 2012;5(11):25-27. 
  26. Tang YT, Wang D, Luo H, Xiao M, Zhou HS, Liu D, Ling SP, Wang N, Hu XL, Luo Y, et al. Aggressive NK-cell leukemia: clinical subtypes, molecular features, and treatment outcomes. Blood Cancer J. 2017;7(12):660.  https://doi.org/10.1038/s41408-017-0021-z
  27. Kempf W, Mitteldorf C, Battistella M, Willemze R, Cerroni L, Santucci M, Geissinger E, Jansen P, Vermeer MH, Marschalko M, et al. Primary cutaneous peripheral T-cell lymphoma, not otherwise specified: results of a multicentre European Organization for Research and Treatment of Cancer (EORTC) cutaneous lymphoma taskforce study on the clinico-pathological and prognostic features. J Eur Acad Dermatol Venereol. 2021;35(3):658-668.  https://doi.org/10.1111/jdv.16969
  28. Perry AM, Bailey NG, Bonnett M, Jaffe ES, Chan WC. Disease progression in a patient with indolent T-cell lymphoproliferative disease of the gastrointestinal tract. Int J Surg Pathol. 2019;27(1):102-107.  https://doi.org/10.1177/1066896918785985
  29. Soderquist CR, Patel N, Murty VV, Betman S, Aggarwal N, Young KH, Xerri L, Leeman-Neill R, Lewis SK, Green PH, et al. Genetic and phenotypic characterization of indolent T-cell lymphoproliferative disorders of the gastrointestinal tract. Haematologica. 2020;105(7):1895-1906. https://doi.org/10.3324/haematol.2019.230961
  30. Xiao W, Gupta GK, Yao J, Jang YJ, Xi L, Baik J, Sigler A, Kumar A, Moskowitz AJ, Arcila ME, et al. Recurrent somatic JAK3 mutations in NK-cell enteropathy. Blood. 2019;134(12):986-991.  https://doi.org/10.1182/blood.2019001443
  31. Mansoor A, Pittaluga S, Beck PL, Wilson WH, Ferry JA, Jaffe ES. NK-cell enteropathy: a benign NK-cell lymphoproliferative disease mimicking intestinal lymphoma: clinicopathologic features and follow-up in a unique case series. Blood. 2011;117(5):1447-1452. https://doi.org/10.1182/blood-2010-08-302737
  32. de Leval L, Savilo E, Longtine J, Ferry JA, Harris NL. Peripheral T-cell lymphoma with follicular involvement and a CD4+/bcl-6+ phenotype. Am J Surg Pathol. 2001;25(3):395-400.  https://doi.org/10.1097/00000478-200103000-00015
  33. Huang Y, Moreau A, Dupuis J, Streubel B, Petit B, Le Gouill S, Martin-Garcia N, Copie-Bergman C, Gaillard F, Qubaja M, et al. Peripheral T-cell lymphomas with a follicular growth pattern are derived from follicular helper T cells (TFH) and may show overlapping features with angioimmunoblastic T-cell lymphomas. Am J Surg Pathol. 2009;33(5):682-690.  https://doi.org/10.1097/PAS.0b013e3181971591
  34. Takahashi E, Asano N, Li C, Tanaka T, Shimada K, Shimada S, Yoshino T, Kojima M, Hara K, Eimoto T, et al. Nodal T/NK-cell lymphoma of nasal type: a clinicopathological study of six cases. Histopathology. 2008;52(5):585-596.  https://doi.org/10.1111/j.1365-2559.2008.02997.x
  35. Wai CMM, Chen S, Phyu T, Fan S, Leong SM, Zheng W, Low LCY, Choo SN, Lee CK, Chung TH, et al. Immune pathway upregulation and lower genomic instability distinguish EBV-positive nodal T/NK-cell lymphoma from ENKTL and PTCL-NOS. Haematologica. 2022;107(8):1864-1879. https://doi.org/10.3324/haematol.2021.280003
  36. Ha SY, Sung J, Ju H, Karube K, Kim SJ, Kim WS, Seto M, Ko YH. Epstein-Barr virus-positive nodal peripheral T cell lymphomas: clinicopathologic and gene expression profiling study. Pathol Res Pract. 2013;209(7):448-454.  https://doi.org/10.1016/j.prp.2013.04.013
  37. Xiao W, Chan A, Waarts MR, Mishra T, Liu Y, Cai SF, Yao J, Gao Q, Bowman RL, Koche RP, et al. Plasmacytoid dendritic cell expansion defines a distinct subset of RUNX1-mutated acute myeloid leukemia. Blood. 2021;137(10):1377-1391. https://doi.org/10.1182/blood.2020007897
  38. Chang KTE, Tay AZE, Kuick CH, Chen H, Algar E, Taubenheim N, Campbell J, Mechinaud F, Campbell M, Super L, et al. ALK-positive histiocytosis: an expanded clinicopathologic spectrum and frequent presence of KIF5B-ALK fusion. Mod Pathol. 2019;32(5):598-608.  https://doi.org/10.1038/s41379-018-0168-6
  39. van Nierop K, de Groot C. Human follicular dendritic cells: function, origin and development. Semin Immunol. 2002;14(4):251-257.  https://doi.org/10.1016/s1044-5323(02)00057-x

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