Takotsubo syndrome (stress-induced cardiomyopathy)

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The article presents published and own data about Takotsubo syndrome, a relatively rare heart disease that is similar to acute coronary syndrome, but without significant damage of coronary arteries. The leading pathogenetic factor is the catecholamine-induced stress damage of myocardium with involvement of microvessels. There is a certain underestimation of Takotsubo syndrome by both clinicians and pathologists, so some cases of Takotsubo syndrome are misdiagnosed as acute coronary syndrome. Morphological manifestations of Takotsubo syndrome are characterized by mucoid edema of interstitial myocardial tissue, round-cell infiltration of stroma and focal damage of cardiomyocytes.

Keywords:

Takotsubo syndrome

stress cardiomyopathy

clinical morphology

Authors:

Kakturskiy L.V.

Research Institute of Human Morphology

Mikhaleva L.M.

A.P. Avtsyn Research Institute of Human Morphology

ORCID: 0000-0003-2052-914X

Mishnev O.D.

Russian National Research Medical University named after N.I. Pirogov

Zairatyants O.V.

Research Institute of Human Morphology;
Moscow State Medical and Dental University named after A.I. Evdokimov

ORCID: 0000-0003-3606-3823

Kurilina E.V.

Myasnikov National Medical Research Center of Cardiology

Komlev A.E.

Chazov National Research Center of Cardiology

ORCID: 0000-0001-6908-7472

Received:

09.11.2020

Accepted:

16.11.2020

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