Essential cryoglobulinemic vasculitis with the development of mesenteric vascular thrombosis and intestinal gangrene

Severgina L.O.; Studennikova V.V.; Radenska-Lopovok S.G.; Kogan E.A.; Novikov P.I.; Korovin I.A.

doi:https://doi.org/10.17116/patol20188005140

Severgina L.O.

Sechenov First Moscow State Medical University, Ministry of Health of the Russia, Moscow, Russia

Studennikova V.V.

Sechenov First Moscow State Medical University, Ministry of Health of the Russia, Moscow, Russia

Radenska-Lopovok S.G.

FGBU "Nauchno-issledovatel'skiĭ institut revmatologii im. V.A. Nasonovoĭ" RAMN, Moskva

ORCID: 0000-0002-4669-260X

Kogan E.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Novikov P.I.

UCH №3 of I.M. Sechenov First Moscow State Medical University, 11, str.5 Rossolimo St., Moscow, Russian Federation, 119021

Korovin I.A.

Sechenov First Moscow State Medical University, Ministry of Health of the Russia, Moscow, Russia

Essential cryoglobulinemic vasculitis with the development of mesenteric vascular thrombosis and intestinal gangrene

Authors:

Severgina L.O., Studennikova V.V., Radenska-Lopovok S.G., Kogan E.A., Novikov P.I., Korovin I.A.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2018;80(5): 40‑45

DOI: 10.17116/patol20188005140

Read: 3486 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Severgina LO, Studennikova VV, Radenska-Lopovok SG, Kogan EA, Novikov PI, Korovin IA. Essential cryoglobulinemic vasculitis with the development of mesenteric vascular thrombosis and intestinal gangrene. Russian Journal of Archive of Pathology. 2018;80(5):40‑45. (In Russ.)
https://doi.org/10.17116/patol20188005140

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

Challenges of differential diagnosis in the verification of Behçet’s disease with neurological manifestations. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4):108-113

Abstract:

The paper describes a case of essential cryoglobulinemia unassociated with hepatitis B and C viruses. The morphological substrate of the disease was exclusively proliferative endothrombovasculitis without destructive changes in the walls of affected vessels. In addition, in the late stage of the disease, there was its unusual manifestation associated with inflammation of the mesentery arteriolar walls and with the formation of occlusive blood clots in their lumens, which led to severe abdominal diseases. The female patient showed a mosaic involvement of the loops of the bowel in the necrotic process as its separate segments, which was associated with damage to a large number of small vessels. The feature of the case is a set of 4 risk factors for a fatal disease outcome, such as age over 65 years, pulmonary, renal, and intestinal lesions.

Keywords:

cryoglobulinemia

essential cryoglobulinemia

vasculitis

mesangiocapillary glomerulonephritis

Authors:

Severgina L.O.

Sechenov First Moscow State Medical University, Ministry of Health of the Russia, Moscow, Russia

Studennikova V.V.

Sechenov First Moscow State Medical University, Ministry of Health of the Russia, Moscow, Russia

Radenska-Lopovok S.G.

FGBU "Nauchno-issledovatel'skiĭ institut revmatologii im. V.A. Nasonovoĭ" RAMN, Moskva

ORCID: 0000-0002-4669-260X

Kogan E.A.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Novikov P.I.

UCH №3 of I.M. Sechenov First Moscow State Medical University, 11, str.5 Rossolimo St., Moscow, Russian Federation, 119021

Korovin I.A.

Sechenov First Moscow State Medical University, Ministry of Health of the Russia, Moscow, Russia

Close metadata

References:

Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013;65(1):1-11.
Jennette J. Overview of the 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Clin Exp Nephrol. 2013;17(5):603-606.
Waller R, Ahmed A, Patel I, Luqmani R. Update on the classification of vasculitis. Best Pract Res Clin Rheumatol. 2013;27 (1):3-17.
Bonetto C, Trottaa F, Felicettia P, Alarcónp GS, Santuccioa C, Bachtiarb NS, et al. Vasculitis as an adverse event following immunization – Systematic literature review. Vaccine. 2016;34(51):6641-6651. https://doi.org/10.1016/j.vaccine.2015.09.026
Damoiseaux J. The diagnosis and classification of the cryoglobulinemic syndrome. Autoimmun Rev. 2014;13(4-5):359-362.
Tedeschi A, Baratè C, Minola E, Morra E. Cryoglobulinemia. Blood Rev. 2007;21(4):183-200.
Perez-Alamino R, Espinoza LR. Non-infectious cryoglobulinemia vasculitis (CryoVas): update on clinical and therapeutic approach. Curr Rheumatol Rep. 2014;16(5):420.
Terrier B, Marie I, Lacraz A, Belenotti P, Bonnet F, Chiche L, et al. Non HCV-related infectious cryoglobulinemia vasculitis: Results fromthe French nationwide CryoVas survey and systematic review of the literature. J Autoimmun. 2015;65:74-81.
Terrier B, Cacoub P. Cryoglobulinemia vasculitis: an update. Curr Opin Rheumatol. 2013;25(1):10-18.
Cacoub P, Comarmond C, Domont F, Savey L, Saadoun D. Cryoglobulinemia vasculitis. Am J Med. 2015;128(9):950-955.
Terrier B, Krastinova E, Marie I, Launay D, Lacraz A, Belenotti P, et al. Management of non infectious mixed cryoglobulinemia vasculitis: data from 242 cases included in the CryoVas survey. Blood. 2012;119(25):5996-6004.