The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Radenska-Lopovok S.G.

FGBU "Nauchno-issledovatel'skiĭ institut revmatologii im. V.A. Nasonovoĭ" RAMN, Moskva

Volkova P.

N.I. Pirogov Russian National Research Medical University, Moscow, Russia

Is scleromyxedema a skin problem or systemic pathological process?

Authors:

Radenska-Lopovok S.G., Volkova P.

More about the authors

Read: 1766 times


To cite this article:

Radenska-Lopovok SG, Volkova P. Is scleromyxedema a skin problem or systemic pathological process? Russian Journal of Archive of Pathology. 2018;80(1):63‑66. (In Russ.)
https://doi.org/10.17116/patol201880163-66

Recommended articles:
Quality control of immu­nohistochemical studies: compulsory duty or urgent need?. Russian Journal of Archive of Pathology. 2025;(2):43-52

References:

  1. Rongioletti F. Mucinoses. In: Rongioletti F, Smoller BR, eds. Clinical and pathological aspects of skin diseases in endocrine, metabolic, nutritional and deposition disease. New York (NY): Springer; 2010:139-152. https://doi.org/10.1007/978-1-60761-181-3
  2. Alligood TR, Burnett JW, Raines BL Jr. Scleromyxedema associated with esophageal aperistalsis and dermal eosinophilia. Cutis. 1981;28:60-63. PMID: 7261674
  3. Rongioletti F, Cozzani E, Parodi A. Scleromyxedema with an interstitial granulomatous-like pattern: a rare histologic variant mimicking granuloma annulare. J Cutan Pathol. 2010;37(10):1084-1087. https://doi.org/10.1111/j.1600-0560.2009.01386.x
  4. Dubreuilh W. Fibromes miliaires folliculaires: sclerodemie consecutive. Ann Dermatol Syph. 1906;37:569-572. https://doi.org/10.2147/IMCRJ.S115315
  5. Reitmann K. Uber eineeigenartige, der Sklerodermie nahestehende Affektion. Arch Dermatol Syph. 1908;92:417-424. https://doi.org/10.1007/BF01949029
  6. Montgomery H, Underwood LJ. Lichen myxedematosus; differentiation from cutaneous myxedemas or mucoid states. J Invest Dermatol. 1953;20(3):213-236. https://doi.org/10.1038/jid.1953.25
  7. Gottron HA. Scleromyxedema; a strange manifestation of myxothesaurodermy. Arch Klin Exp Dermatol. 1954;199(1):71-91.
  8. Rongioletti F, Rebora A. Updated classification of papular mucinosis, lichen myxedematosus, and scleromyxedema. J Am Acad Dermatol. 2001;44(2):273-281. https://doi.org/10.1067/mjd.2001.111630
  9. Rongioletti F, Merlo G, Carli C, Cribier B, Metze D, Calonje E, Kempf W, Stefanato CM, Marinho E, Kanitakis J. Histopathologic characteristics of scleromyxedema: a study of a series of 34 cases. J Am Acad Dermatol. 2016;74(6):1194-1200. https://doi.org/10.1016/j.jaad.2015.12.021
  10. L’vov AN, Sheklakova MN, Matushevskaya YuI, Znamenskaya LF, Svishchenko SI, Katunina OR, Chikin VV, Yakovleva AO. Arndt—Gottron scleromyxedema. Vestnik dermatologii i venerologii. 2012;(5):71-77. (In Russ.)
  11. Lacy MQ, Hogan WJ, Gertz MA, Dispenzieri A, Rajkumar SV, Hayman S, Kumar S, Litzow MR, Schroeter AL. Successful treatment of scleromyxedema with autologous peripheral blood stem cell transplantation. Arch Dermatol. 2005;141(10):1277-1282. https://doi.org/10.1001/archderm.141.10.1277
  12. Dinneen AM, Dicken CH. Scleromyxedema. J Am Acad Dermatol. 1995;33(1):37-43. PMID: 7601944
  13. Donato ML, Feasel AM, Weber DM, Prieto VG, Giralt SA, Champlin RE, Duvic M. Scleromyxedema: role of high-dose melphalan with autologous stem cell transplantation. Blood. 2006;107(2):463-466. https://doi.org/10.1182/blood-2004-12-4870
  14. Harper RA, Rispler J. Lichen myxedematosus serum stimulates human skin fibroblast proliferation. Science. 1978;199(4328):545-547. https://doi.org/10.1126/science.622555
  15. Braun-Falco O, Weidner F. Arndt-Gottron scleromyxedema with medullary plasmacytosis and myositis. Arch Belg Dermatol Syphiligr. 1970;26(2):193-217. https://doi.org/10.1007/978-3-642-97931-6_43
  16. Harris RB, Perry HO, Kyle RA, Winkelmann RK. Treatment of scleromyxedema with melphalan. Arch Dermatol. 1979;115(3):295-299. https://doi.org/10.1001/archderm.1979.04010030003002
  17. James K, Fudenberg H, Epstein WL, Shuster J. Studies on a unique diagnostic serum globulin in papular mucinosis (lichen myxedematosus). Clin Exp Immunol. 1967;2(2):153-166. PMC 1578836
  18. Shapiro CM, Fretzin D, Norris S. Papular mucinosis. JAMA. 1970;214(11):2052-2054. https://doi.org/10.1001/jama.1970.03180110060017
  19. Piper W, Hardmeier T, Schafer E. Scleromyxedema Arndt-Gottron: a paraproteinemic disease. Schweiz Med Wochenschr. 1967;97(26):829-838. PMID: 4166238 PMCID: PMC1578836
  20. McCarthy JT, Osserman E, Lombardo PC, Takatsuki K. An abnormal serum globulin in lichen myxedematosus. Arch Dermatol. 1964;89:446-450. https://doi.org/10.1001/archderm.1964.01590270132030
  21. Rowell NR, Waite A, Scott DG. Multiple serum protein abnormalities in lichen myxoedematosus. Br J Dermatol. 1969;81(10):753-758. https://doi.org/10.1111/j.1365-2133.1969.tb15936.x
  22. Sawada Y, Ohashi M. Scleromyxedema — report of a case with hyperpolygammopathy and immunoglobulin and complement deposition in cutaneous lesions. J Dermatol. 1980;7(3):207-212. https://doi.org/10.1111/j.1346-8138.1980.tb03534.x
  23. Ferrarini M, Helfrich DJ, Walker ER, Medsger TA Jr, Whiteside TL. Scleromyxedema serum increases proliferation but not the glycosaminoglycan synthesis of dermal fibroblasts. J Rheumatol. 1989;16(6):837-841. PMID: 2778769
  24. Yaron M, Yaron I, Yust I, Brenner S. Lichen myxedematosus (scleromyxedema) serum stimulates hyaluronic acid and prostaglandin E production by human fibroblasts. J Rheumatol. 1985;12(1):171-175. PMID: 3981505
  25. White GM, Jeffes EW, 3-rd. Stimulation of fibroblasts by paraprotein in scleromyxedema. J Am Acad Dermatol. 1989;21(4,Pt1):816. https://doi.org/10.1016/S0190-9622(89)80294-4
  26. Boin F, Hummers LK. Scleroderma-like fibrosing disorders. Rheum Dis Clin North Am. 2008;34(1):199-220. https://doi.org/10.1016/j.rdc.2007.11.001
  27. Rongioletti F, Merlo G, Cinotti E, Fausti V, Cozzani E, Cribier B, Metze D, Calonje E, Kanitakis J, Kempf W, Stefanato CM, Marinho E, Parodi A. Scleromyxedema: a multicenter study of characteristics, comorbidities, course, and therapy in 30 patients. J Am Acad Dermatol. 2013;69(1):66-72. https://doi.org/10.1016/j.jaad.2013.01.007
  28. Helfrich DJ, Walker ER, Martinez AJ, Medsger TA Jr. Scleromyxedema myopathy: case report and review of the literature. Arthritis Rheum. 1988;31(11):1437-1441. https://doi.org/10.1002/art.1780311115
  29. McAdam LP, Pearson CM, Pitts WH, Sadoff L, Verity MA. Papular mucinosis with myopathy, arthritis, and eosinophilia. A histopathologic study. Arthritis Rheum. 1977;20(4):989-996. https://doi.org/10.1002/art.1780200412
  30. Gabriel SE, Perry HO, Oleson GB, Bowles CA. Scleromyxedema: a scleroderma-like disorder with systemic manifestations. Medicine (Baltimore). 1988;67(1):58-65. https://doi.org/10.1097/00005792-198801000-00004
  31. Stetsenko GY, Vary JC Jr, Olerud JE, Argenyi ZB. Unusual granulomatous variant of scleromyxedema. J Am Acad Dermatol. 2008;59(2):346-349. https://doi.org/10.1016/j.jaad.2008.04.017
  32. Rongioletti F, Cerroni L, Massone C, Basso M, Ciambellotti A, Rebora A. Different histologic patterns of cutaneous granulomas in systemic lymphoma. J Am Acad Dermatol. 2004;51(4):600-605. https://doi.org/10.1016/j.jaad.2004.02.024
  33. Perry HO, Montgomery H, Stickney JM. Further observations on lichen myxedematosus. Ann Intern Med. 1960;53:955-969. https://doi.org/10.7326/0003-4819-53-5-955
  34. McCuistion CH, Schoch EP Jr. Autopsy findings in lichen myxedematosus. AMA Arch Derm. 1956;74(3):259-262. https://doi.org/10.1001/archderm.1956.01550090033007
  35. Loggini B, Pingitore R, Avvenente A, Giuliano G, Barachini P. Lichen myxedematosus with systemic involvement: clinical and autopsy findings. J Am Acad Dermatol. 2001;45(4):606-608. https://doi.org/10.1067/mjd.2001.111903

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.