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Milovanov A.P.

Laboratoriia patologii zhenskoĭ reproduktivnoĭ sistemy NII morfologii cheloveka RAMN, Moskva

Ozhiganova I.N.

Severo-Zapadnyĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.I. Mechnikova

Ozhiganova I.N.

Severo-Zapadnyĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.I. Mechnikova

Embryochorionic insufficiency: Anatomic and physiologic prerequisites, rationale, definitions and pathogenetic mechanisms

Authors:

Milovanov A.P., Ozhiganova I.N., Ozhiganova I.N.

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Journal: Russian Journal of Archive of Pathology. 2014;76(3): 4‑8

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EMBRYOCHORIONIC INSUFFICIENCY: ANATOMIC AND PHYSIOLOGIC PREREQUISITES, RATIONALE, DEFINITIONS AND PATHOGENETIC MECHANISMS
EMBRYOCHORIONIC INSUFFICIENCY: ANATOMIC AND PHYSIOLOGIC PREREQUISITES, RATIONALE, DEFINITIONS AND PATHOGENETIC MECHANISMS

To cite this article:

Milovanov AP, Ozhiganova IN, Ozhiganova IN. Embryochorionic insufficiency: Anatomic and physiologic prerequisites, rationale, definitions and pathogenetic mechanisms. Russian Journal of Archive of Pathology. 2014;76(3):4‑8. (In Russ.)

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The paper provides a rationale for the new concept - embryochorionic insufficiency as a combined pathological response of extraembryonic structures and an embryo to different maternal exo- and endogenous disorders; it gives rise to early spontaneous abortions and non-developing pregnancies. The main pathogenetic mechanisms of embryochorionic insufficiency are: 1) endometrial structural incompetence; 2) dyschronism in the development of the extraembryonic coelom, amniotic cavity, yolk sac, and early placenta; 3) insufficient cytotrophoblast invasion; 4) discordant hemodynamic relationships; 5) blood rheological disorders; 6) local inflammation (endometritis); 7) oxidative stress; 8) secondary changes in the placental villi; 9) compensatory responses.

Keywords:

extraembryonic structures
embryochorionic insufficiency
non-developing pregnancy
extraembryonic structures
causes and pathogenesis
embryochorionic insufficiency
non-developing pregnancy
causes and pathogenesis

Authors:

Milovanov A.P.

Laboratoriia patologii zhenskoĭ reproduktivnoĭ sistemy NII morfologii cheloveka RAMN, Moskva

Ozhiganova I.N.

Severo-Zapadnyĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.I. Mechnikova

Ozhiganova I.N.

Severo-Zapadnyĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.I. Mechnikova

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References:

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  4. Milovanov A.P., Serova O.F., eds. Prichiny i differentsirovannoe lechenie rannego nevynashivaniya beremennosti [Causes and differentiated treatment of early pregnancy loss]. Moscow: MDV Publ.; 2011. 216 p.
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  8. Jauniaux E., Watson A., Burton G. Evolution of respiratory gases and acid-base gradients in human fetal fruids between 7 and 16 Weeks. Am. J. Obstet. Gynecol. 2001; 184 (5): 998-1003.
  9. Iles R.K., Wathen N.C. Human Chorionic gonadotrophin subunit composition of maternal serum and coelomic fluids in the first trimester of pregnancy. J. Endocrin. 1992; 135: 563-9.
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  11. Milovanov A.P., Radzinskiy V.E. The role of microenvironment in livelihood of human embryo. Akusherstvo i ginekologiya. 2004; 4: 15-18. (In Russ.)
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  15. Milovanov A.P., Ozhiganova I.N. et al. Embryochorial failure and non-developing pregnancy. Nauchnye vedomosti Belgorodskogo gos. universiteta. Ser.: Meditsina. 2013; 4/147 (21/1): 62-68. (In Russ.)
  16. Milovanov A.P., Kirichenko A.K. Tsitotrofoblasticheskaya invaziya - klyuchevoy mekhanizm razvitiya normal'noy i oslozhnennoy beremennosti [Cytotrophoblastic infestation - a key mechanism for the development of normal and complicated pregnancies]. Krasnoyarsk; 2009. 170 p.
  17. Gruzdev S.A., Milovanov A.P. et al. On the role of some placental villi producents in pathogenesis of the retrochorial hematoma in the non-developing pregnancy. Fundamental'nye issledovaniya. Meditsinskie nauki. 2013; 7: 61-67. (In Russ.)
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