The hepatotropic activity of runihol and ademethionine against experimental liver damage caused by first-line antituberculosis drugs

Sukhanov D.S.

Sankt-Peterburgskaia gosudarstvennaia meditsinskaia akademiia im. I.I. Mechnikova

Vinogradova T.I.

Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut ftiziopul'monologii

Zabolotnykh N.V.

Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut ftiziopul'monologii

Vitovskaia M.L.

Laboratoriia éksperimental'nogo tuberkuleza i novykh meditsinskikh tekhnologiĭ FGBU "Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut ftiziopul'monologii" Minzdravsotsrazvitiia Rossii

Kovalenko A.L.

Direktsiia po nauke OOO "NTFF "Polisan", Sankt-Peterburg

The hepatotropic activity of runihol and ademethionine against experimental liver damage caused by first-line antituberculosis drugs

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Sukhanov D.S., Vinogradova T.I., Zabolotnykh N.V., Vitovskaia M.L., Kovalenko A.L.

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Journal: Russian Journal of Archive of Pathology. 2014;76(2): 26‑31

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Sukhanov DS, Vinogradova TI, Zabolotnykh NV, Vitovskaia ML, Kovalenko AL. The hepatotropic activity of runihol and ademethionine against experimental liver damage caused by first-line antituberculosis drugs. Russian Journal of Archive of Pathology. 2014;76(2):26‑31. (In Russ.)

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Experiments on 62 male albino outbred rats investigated the impact of 14-day use of the oral hepatotropic agents ademethionine and runihol in different doses in liver damage caused by a antituberculosis combination (HRZ). HRZ-induced liver damage was shown to be accompanied by the development of cytolysis and cholestasis. The test drugs in the doses under study had a mixed effect, by reducing the magnitude of biochemical manifestations of these syndromes. Both drugs favored the recovery of the structure of the liver and the reduction of the extent of carbohydrate, protein, and fat dystrophies of the organ. As in previous investigations, ademethionine was found to have enhanced activity of alterative processes in the liver.

Keywords:

experimental liver damage

antituberculosis drugs

runihol

adenomethionine

Authors:

Sukhanov D.S.

Sankt-Peterburgskaia gosudarstvennaia meditsinskaia akademiia im. I.I. Mechnikova

Vinogradova T.I.

Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut ftiziopul'monologii

Zabolotnykh N.V.

Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut ftiziopul'monologii

Vitovskaia M.L.

Laboratoriia éksperimental'nogo tuberkuleza i novykh meditsinskikh tekhnologiĭ FGBU "Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut ftiziopul'monologii" Minzdravsotsrazvitiia Rossii

Kovalenko A.L.

Direktsiia po nauke OOO "NTFF "Polisan", Sankt-Peterburg

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