Fatty acid-binding protein as a marker of intestinal damage and potential predictor of mortality in acute period of burn disease

O.V. Kostina

Privolzhsky Research Medical University

ORCID: 0000-0001-7529-2544

N.V. Didenko

Privolzhsky Research Medical University

ORCID: 0000-0001-6653-1267

E.A. Galova

Privolzhsky Research Medical University

ORCID: 0000-0002-9574-2933

A.S. Pushkin

Privolzhsky Research Medical University

ORCID: 0000-0002-7170-7885

V.I. Zagrekov

Privolzhsky Research Medical University

ORCID: 0000-0001-8235-7705

V.I. Ashkinazi

Privolzhsky Research Medical University

ORCID: 0000-0003-3376-566X

M.V. Presnyakova

Privolzhsky Research Medical University

ORCID: 0000-0002-3951-9403

Fatty acid-binding protein as a marker of intestinal damage and potential predictor of mortality in acute period of burn disease

Authors:

O.V. Kostina, N.V. Didenko, E.A. Galova, A.S. Pushkin, V.I. Zagrekov, V.I. Ashkinazi, M.V. Presnyakova

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2023;(6): 52‑57

DOI: 10.17116/anaesthesiology202306152

Downloaded: 33

To cite this article:

Kostina OV, Didenko NV, Galova EA, Pushkin AS, Zagrekov VI, Ashkinazi VI, Presnyakova MV. Fatty acid-binding protein as a marker of intestinal damage and potential predictor of mortality in acute period of burn disease. Russian Journal of Anesthesiology and Reanimatology. 2023;(6):52‑57. (In Russ., In Engl.)
https://doi.org/10.17116/anaesthesiology202306152

Доказательная гастроэнтерология: pro et contra

Актуальные вопросы педиатрической практики

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OBJECTIVE

To study intestinal fatty acid-binding protein (I-FABP) changes in acute period of burn disease and evaluate the capabilities of this biomarker for prediction of mortality.

MATERIAL AND METHODS

There were 38 patients with burns of 50.7±17.2% of body surface; 7 patients died. Blood sampling was carried out in 1, 2, 3, 6±2, 9±2 and 11±2 days after injury. We analyzed I-FABP concentration, free radical processes according to biochemiluminescence analysis, lipid peroxidation and activity of catalase and superoxide dismutase.

RESULTS

I-FABP was increased throughout the study. There was a correlation between I-FABP level and pro-/antioxidant imbalance. Deceased patients had 4—37 times higher concentration of I-FABP compared to survivors. The maximum values were recorded in patients with early sepsis and fatal outcome. Logistic regression revealed a relationship between mortality and high I-FABP level. I-FABP >143.6 pg/ml had good specificity (71.4%), sensitivity (81.5%) and diagnostic efficacy (79%) regarding the risk of mortality. ROC analysis demonstrated acceptable informative value of I-FABP (AUC 0.783±0.137).

CONCLUSION

Acute period of burn disease is accompanied by increased serum I-FABP. Enterocyte membrane damage is associated with imbalance between pro- and antioxidants. Increased I-FABP correlated with sepsis. I-FABP >143.6 pg/ml in severely burned patients has significant prognostic value for mortality.

Keywords:

intestinal fatty acid binding protein (I-FABP)

burn disease

Authors:

O.V. Kostina

Privolzhsky Research Medical University

ORCID: 0000-0001-7529-2544

N.V. Didenko

Privolzhsky Research Medical University

ORCID: 0000-0001-6653-1267

E.A. Galova

Privolzhsky Research Medical University

ORCID: 0000-0002-9574-2933

A.S. Pushkin

Privolzhsky Research Medical University

ORCID: 0000-0002-7170-7885

V.I. Zagrekov

Privolzhsky Research Medical University

ORCID: 0000-0001-8235-7705

V.I. Ashkinazi

Privolzhsky Research Medical University

ORCID: 0000-0003-3376-566X

M.V. Presnyakova

Privolzhsky Research Medical University

ORCID: 0000-0002-3951-9403

Received:

13.06.2023

Accepted:

12.07.2023

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