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Kostina O.V.

Privolzhsky Research Medical University

Didenko N.V.

Privolzhsky Research Medical University

Galova E.A.

Privolzhsky Research Medical University

Pushkin A.S.

Privolzhsky Research Medical University

Zagrekov V.I.

Privolzhsky Research Medical University

Ashkinazi V.I.

Privolzhsky Research Medical University

Presnyakova M.V.

Privolzhsky Research Medical University

Fatty acid-binding protein as a marker of intestinal damage and potential predictor of mortality in acute period of burn disease

Authors:

Kostina O.V., Didenko N.V., Galova E.A., Pushkin A.S., Zagrekov V.I., Ashkinazi V.I., Presnyakova M.V.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2023;(6): 52‑57

DOI: 10.17116/anaesthesiology202306152

Read: 2483 times

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Table of contents

FATTY ACID-BINDING PROTEIN AS A MARKER OF INTESTINAL DAMAGE AND POTENTIAL PREDICTOR OF MORTALITY IN ACUTE PERIOD OF BURN DISEASE
FATTY ACID-BINDING PROTEIN AS A MARKER OF INTESTINAL DAMAGE AND POTENTIAL PREDICTOR OF MORTALITY IN ACUTE PERIOD OF BURN DISEASE

To cite this article:

Kostina OV, Didenko NV, Galova EA, Pushkin AS, Zagrekov VI, Ashkinazi VI, Presnyakova MV. Fatty acid-binding protein as a marker of intestinal damage and potential predictor of mortality in acute period of burn disease. Russian Journal of Anesthesiology and Reanimatology. 2023;(6):52‑57. (In Russ., In Engl.)
https://doi.org/10.17116/anaesthesiology202306152

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Abstract:

OBJECTIVE

To study intestinal fatty acid-binding protein (I-FABP) changes in acute period of burn disease and evaluate the capabilities of this biomarker for prediction of mortality.

MATERIAL AND METHODS

There were 38 patients with burns of 50.7±17.2% of body surface; 7 patients died. Blood sampling was carried out in 1, 2, 3, 6±2, 9±2 and 11±2 days after injury. We analyzed I-FABP concentration, free radical processes according to biochemiluminescence analysis, lipid peroxidation and activity of catalase and superoxide dismutase.

RESULTS

I-FABP was increased throughout the study. There was a correlation between I-FABP level and pro-/antioxidant imbalance. Deceased patients had 4—37 times higher concentration of I-FABP compared to survivors. The maximum values were recorded in patients with early sepsis and fatal outcome. Logistic regression revealed a relationship between mortality and high I-FABP level. I-FABP >143.6 pg/ml had good specificity (71.4%), sensitivity (81.5%) and diagnostic efficacy (79%) regarding the risk of mortality. ROC analysis demonstrated acceptable informative value of I-FABP (AUC 0.783±0.137).

CONCLUSION

Acute period of burn disease is accompanied by increased serum I-FABP. Enterocyte membrane damage is associated with imbalance between pro- and antioxidants. Increased I-FABP correlated with sepsis. I-FABP >143.6 pg/ml in severely burned patients has significant prognostic value for mortality.

Keywords:

intestinal fatty acid binding protein (I-FABP)
burn disease

Authors:

Kostina O.V.

Privolzhsky Research Medical University

Didenko N.V.

Privolzhsky Research Medical University

Galova E.A.

Privolzhsky Research Medical University

Pushkin A.S.

Privolzhsky Research Medical University

Zagrekov V.I.

Privolzhsky Research Medical University

Ashkinazi V.I.

Privolzhsky Research Medical University

Presnyakova M.V.

Privolzhsky Research Medical University

Received:

13.06.2023

Accepted:

12.07.2023

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