Проблема межлекарственных взаимодействий у пациентов в критическом состоянии: систематический обзор

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Межлекарственные взаимодействия (МЛВ) являются распространенными и предотвратимыми осложнениями, связанными как с увеличением длительности пребывания пациента в отделении реанимации и интенсивной терапии (ОРИТ) и в стационаре, так и с высоким риском неблагоприятного исхода. Пациенты в критическом состоянии представляют собой группу высокого риска развития МЛВ из-за часто возникающего нарушения адсорбции лекарственных препаратов, снижения функциональной активности почек и печени, а также вследствие полипрагмазии. Профилактика МЛВ является важным аспектом безопасности пациента в ОРИТ. Однако данной проблеме уделено недостаточно внимания — к настоящему времени выполнено небольшое количество исследований с анализом возникновения МЛВ у пациентов, находящихся в ОРИТ. В связи с этим проведен обзор данных о МЛВ в ОРИТ, в том числе о частоте и принципах их формирования.

Ключевые слова:

межлекарственные взаимодействия

пациенты в критическом состоянии

полипрагмазия

система поддержки принятия решений

Авторы:

Баранич А.И.

ФГАУ «Национальный медицинский исследовательский центр нейрохирургии им. акад. Н.Н. Бурденко» Минздрава России;
ФГБОУ ВО «Российский экономический университет им. Г.В. Плеханова» Минобрнауки России

ORCID: 0000-0002-1167-0742

Сычев А.А.

ФГАУ «Национальный медицинский исследовательский центр нейрохирургии им. акад. Н.Н. Бурденко» Минздрава России

SPIN РИНЦ: 1171-7690
Scopus AuthorID: 36997601100
ORCID: 0000-0002-0038-1005

Савин И.А.

ФГАУ «Национальный медицинский исследовательский центр нейрохирургии им. ак. Н.Н. Бурденко» Минздрава России

ORCID: 0000-0003-2594-5441

Кудрина В.Г.

ФГБОУ ВО «Российский экономический университет им. Г.В. Плеханова» Минобрнауки России;
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России

ORCID: 0000-0002-4329-1165

Дата поступления:

04.05.2023

Дата принятия в печать:

08.06.2023

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