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Bykova K.M.

Almazov National Medical Research Centre

Savvina I.A.

Polenov Neurosurgical Institute;
Mechnikov North-West State Medical University

Bodareva N.V.

Almazov National Medical Research Centre

Zabrodskaya Yu.M.

Prof. A.L. Polenov Russian Research Institute of Neurosurgery — Branch V.A. Almazov National Medical Research Center of the Ministry of Health of Russia

Pathophysiological aspects and complex diagnosis of sepsis-associated encephalopathy. Prospects for etiopathogenetic therapy

Authors:

Bykova K.M., Savvina I.A., Bodareva N.V., Zabrodskaya Yu.M.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2022;(4): 92‑98

DOI: 10.17116/anaesthesiology202204192

Read: 3355 times

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Table of contents

PATHOPHYSIOLOGICAL ASPECTS AND COMPLEX DIAGNOSIS OF SEPSIS-ASSOCIATED ENCEPHALOPATHY. PROSPECTS FOR ETIOPATHOGENETIC THERAPY
PATHOPHYSIOLOGICAL ASPECTS AND COMPLEX DIAGNOSIS OF SEPSIS-ASSOCIATED ENCEPHALOPATHY. PROSPECTS FOR ETIOPATHOGENETIC THERAPY

To cite this article:

Bykova KM, Savvina IA, Bodareva NV, Zabrodskaya YuM. Pathophysiological aspects and complex diagnosis of sepsis-associated encephalopathy. Prospects for etiopathogenetic therapy. Russian Journal of Anesthesiology and Reanimatology. 2022;(4):92‑98. (In Russ.)
https://doi.org/10.17116/anaesthesiology202204192

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Abstract:

Dysfunction of the central nervous system following sepsis is realized in sepsis-associated encephalopathy (SAE) with neurological impairment including delirium and coma. Septic encephalopathy, being a risk factor for long-term disorders of consciousness and mortality, is singled out as an independent syndrome requiring further pathogenetic study for effective diagnostic approaches and prognosis. Pathophysiological mechanisms of septic encephalopathy are diverse and poorly understood. Methods of laboratory, radiological and functional diagnosis reveal non-specific functional and structural changes in central nervous system typical for acute cerebral injury, which requires further study of the problem. Management of sepsis-associated encephalopathy is based on etiopathogenetic therapy of sepsis, normalization of neuronal metabolic activity and function of blood-brain barrier, as well as control of neuroinflammation. Experimental studies demonstrate perspective directions for research of this problem.

Keywords:

sepsis-associated encephalopathy
cognitive impairment
neuroinflammation
blood-brain barrier
etiopathogenetic therapy

Authors:

Bykova K.M.

Almazov National Medical Research Centre

Savvina I.A.

Polenov Neurosurgical Institute;
Mechnikov North-West State Medical University

Bodareva N.V.

Almazov National Medical Research Centre

Zabrodskaya Yu.M.

Prof. A.L. Polenov Russian Research Institute of Neurosurgery — Branch V.A. Almazov National Medical Research Center of the Ministry of Health of Russia

Received:

18.04.2022

Accepted:

10.05.2022

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