The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Kulikov A.V.

Ural State Medical University

Shifman E.M.

Moscow Regional Research and Clinical Institute

Protsenko D.N.

«Kommunarka» Moscow Multidisciplinary Clinical Center of the Moscow City Healthcare Department;
N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia

Zabolotskikh I.B.

Kuban State Medical University

Ovezov A.M.

Moscow Regional Research and Clinical Institute

Roitman E.V.

Pirogov Russian National Research Medical University;
Research Center of Neurology

Artymuk N.V.

Kemerovo State Medical Academy

Astakhov A.A.

South Ural State Medical University

Belokrinitskaya T.E.

Chita State Medical Academy

Ronenson A.M.

Bakunina Regional Clinical Perinatal Centre

Gorokhovskiy V.S.

Far Eastern State Medical University

Matkovskiy A.A.

Ural State Medical University

Raspopin Yu.S.

Voino-Yasenetsky Krasnoyarsk State Medical University

Ryazanova O.V.

Ott Research Institute of Obstetrics, Gynecology and Reproduction

Pylaeva N.Yu.

Vernadsky Crimean Federal University

Diagnosis and intensive therapy of disseminated intravascular coagulation syndrome in massive blood loss in obstetrics (guidelines)

Authors:

Kulikov A.V., Shifman E.M., Protsenko D.N., Zabolotskikh I.B., Ovezov A.M., Roitman E.V., Artymuk N.V., Astakhov A.A., Belokrinitskaya T.E., Ronenson A.M., Gorokhovskiy V.S., Matkovskiy A.A., Raspopin Yu.S., Ryazanova O.V., Pylaeva N.Yu.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2022;(2): 5‑23

DOI: 10.17116/anaesthesiology20220215

Read: 10640 times

Download PDF (RU)
Contact the author
Table of contents

DIAGNOSIS AND INTENSIVE THERAPY OF DISSEMINATED INTRAVASCULAR COAGULATION SYNDROME IN MASSIVE BLOOD LOSS IN OBSTETRICS (GUIDELINES)
DIAGNOSIS AND INTENSIVE THERAPY OF DISSEMINATED INTRAVASCULAR COAGULATION SYNDROME IN MASSIVE BLOOD LOSS IN OBSTETRICS (GUIDELINES)

To cite this article:

Kulikov AV, Shifman EM, Protsenko DN, et al. . Diagnosis and intensive therapy of disseminated intravascular coagulation syndrome in massive blood loss in obstetrics (guidelines). Russian Journal of Anesthesiology and Reanimatology. 2022;(2):5‑23. (In Russ.)
https://doi.org/10.17116/anaesthesiology20220215

МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Abstract:

The article presents recommendations for the diagnosis and intensive care of DIC syndrome in massive blood loss in obstetrics. Issues of clinical, laboratory and instrumental diagnostics of DIC-syndrome in massive blood loss in obstetrics, application of allogeneic blood components (erythrocytes, plasma, cryoprecipitate, platelets) and blood coagulation factors (factor Vlla, concentrate of prothrombin complex factors) are considered. The quality criteria of medical patients with DIC-syndrome in massive blood loss are presented.

Keywords:

massive blood loss
cagulopathy
disseminated intravascular blood coagulation syndrome
DIC syndrome
obstetrics
blood components
blood coagulation factors

Authors:

Kulikov A.V.

Ural State Medical University

Shifman E.M.

Moscow Regional Research and Clinical Institute

Protsenko D.N.

«Kommunarka» Moscow Multidisciplinary Clinical Center of the Moscow City Healthcare Department;
N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia

Zabolotskikh I.B.

Kuban State Medical University

Ovezov A.M.

Moscow Regional Research and Clinical Institute

Roitman E.V.

Pirogov Russian National Research Medical University;
Research Center of Neurology

Artymuk N.V.

Kemerovo State Medical Academy

Astakhov A.A.

South Ural State Medical University

Belokrinitskaya T.E.

Chita State Medical Academy

Ronenson A.M.

Bakunina Regional Clinical Perinatal Centre

Gorokhovskiy V.S.

Far Eastern State Medical University

Matkovskiy A.A.

Ural State Medical University

Raspopin Yu.S.

Voino-Yasenetsky Krasnoyarsk State Medical University

Ryazanova O.V.

Ott Research Institute of Obstetrics, Gynecology and Reproduction

Pylaeva N.Yu.

Vernadsky Crimean Federal University

Close metadata

References:

  1. Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M; Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH). Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost. 2001;86(5):1327-1330.
  2. Gando S, Fujishima S, Saitoh D, Shiraishi A, Yamakawa K, et al. Japanese Association for Acute Medicine (JAAM) Focused Outcomes Research in Emergency Care in Acute Respiratory Distress Syndrome, Sepsis and Trauma (FORECAST) Study Group. The significance of disseminated intravascular coagulation on multiple organ dysfunction during the early stage of acute respiratory distress syndrome. Thromb Res. 2020;191:15-21.  https://doi.org/10.1016/j.thromres.2020.03.023
  3. Fujishima S. Organ dysfunction as a new standard for defining sepsis. In- flamm Regen. 2016;36:24.  https://doi.org/10.1186/s41232-016-0029-y
  4. Colling ME, Bendapudi PK. Purpura Fulminans: Mechanism and Management of Dysregulated Hemostasis. Transfus Med Rev. 2018;32(2):69-76.  https://doi.org/10.1016/j.tmrv.2017.10.001
  5. National Clinical Guideline Centre (UK). Blood Transfusion. London: National Institute for Health and Care Excellence (UK); 2015 Nov. 
  6. Jackson DL, DeLoughery TG. Postpartum Hemorrhage: Management of Massive Transfusion. Obstet Gynecol Surv. 2018;73(7):418-422. 
  7. Tanaka H, Matsunaga S, Yamashita T, Okutomi T, et al. A systematic review of massive transfusion protocol in obstetrics. Taiwan J Obstet Gynecol. 2017;56(6):715-718. 
  8. Pacheco LD, Saade GR, Costantine MM, Clark SL, Hankins GD. An update on the use of massive transfusion protocols in obstetrics. Am J Obstet Gynecol. 2016;214(3):340-344. 
  9. O’Brien KL, Shainker SA, Lockhart EL. Transfusion Management of Obstetric Hemorrhage. Transfus Med Rev. 2018;32(4):249-255. 
  10. Lavee O, Kidson-Gerber G. Update on inherited disorders of haemostasis and pregnancy. Obstet Med. 2016;9(2):64-72. 
  11. Disorders of Thrombosis and Hemostasis in Pregnancy. A Guide to Management edit. Cohen H, O’Brien P. Springer. 2012:252. 
  12. Edwards HM. Aetiology and treatment of severe postpartum haemorrhage. Dan Med J. 2018;65(3).
  13. Kozek-Langenecker SA. Fluids and coagulation. Curr Opin Crit Care. 2015;21(4):285-291. 
  14. Gillissen A, van den Akker T, Caram-Deelder C, Henriquez DDCA, et al. TeMpOH-1 study group Association between fluid management and dilu- tional coagulopathy in severe postpartum haemorrhage: A nationwide retrospective cohort study. BMC Pregnancy Childbirth. 2018;18(1):398. 
  15. Duan C, Li T, Liu L. Efficacy of limited fluid resuscitation in patients with hemorrhagic shock: A meta-analysis. Int J Clin Exp Med. 2015;8(7):11645-11656.
  16. Tinawi M. New Trends in the Utilization of Intravenous Fluids. Cureus. 2021;13(4):e14619. https://doi.org/10.7759/cureus.14619
  17. Iba T, Umemura Y, Wada H, Levy JH. Roles of Coagulation Abnormalities and Microthrombosis in Sepsis: Pathophysiology, Diagnosis, and Treatment. Arch Med Res. 2021;52(8):788-797.  https://doi.org/10.1016/j.arcmed.2021.07.003
  18. Paramo JA. Microvascular thrombosis and clinical implications. Med Clin (Barc). 2021;156(12):609-614. English, Spanish. https://doi.org/10.1016/j.medcli.2020.12.042
  19. Adelborg K, Larsen JB, Hvas AM. Disseminated intravascular coagulation: epidemiology, biomarkers, and management. Br J Haematol. 2021;192(5):803-818.  https://doi.org/10.1111/bjh.17172
  20. Chang JC. Disseminated intravascular coagulation: new identity as endothe- liopathy-associated vascular microthrombotic disease based on in vivo hemostasis and endothelial molecular pathogenesis. Thromb J. 2020;18:25.  https://doi.org/10.1186/s12959-020-00231-0
  21. Nyflqt LT, Sandven I, Stray-Pedersen B, Pettersen S, et al. Risk factors for severe postpartum hemorrhage: a case-control study. BMC Pregnancy Childbirth. 2017;17(1):17. 
  22. Margarido C, Ferns J, Chin V, Ribeiro T, et al. Massive hemorrhage protocol activation in obstetrics: A 5-year quality performance review. Int J Ob- stetAnesth. 2018 Nov 3. pii: S0959-289X(18)30193-6. 
  23. Iqbal K, Iqbal A, Rathore SS, Ahmed J, Ali SA, Farid E, Hasanain M, Azeem Q, Qadar LT, Memon FR, Azim D. Risk factors for blood transfusion in Cesarean section: A systematic review and meta-analysis. Transfus Clin Biol. 2021:S1246-7820(21)00477-8.  https://doi.org/10.1016/j.tracli.2021.09.010
  24. Liu CN, Yu FB, Xu YZ, Li JS, Guan ZH, Sun MN, Liu CA, He F, Chen DJ. Prevalence and risk factors of severe postpartum hemorrhage: A retrospective cohort study. BMC Pregnancy Childbirth. 2021;21(1):332.  https://doi.org/10.1186/s12884-021-03818-1
  25. Iba T, Connors JM, Nagaoka I, Levy JH. Recent advances in the research and management of sepsis-associated DIC. Int J Hematol. 2021; 113(1):24-33.  https://doi.org/10.1007/s12185-020-03053-y
  26. Ikezoe T. Advances in the diagnosis and treatment of disseminated intravascular coagulation in haematological malignancies. Int J Hematol. 2021;113(l):34-44.  https://doi.org/10.1007/sl2185-020-02992-w
  27. Spahn DR, Bouillon B, Cerny V, Duranteau J, Filipescu D, Hunt BJ, Ko- madina R, Maegele M, Nardi G, Riddez L, Samama CM, Vincent JL, Ros- saint R. The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition. Crit Care. 2019;23(1):98.  https://doi.org/10.1186/s13054-019-2347-3
  28. Goad L, Rockhill K, Schwarz J, Heyborne K, Fabbri S. Development and validation of a prediction model for postpartum hemorrhage at a single safety net tertiary care center. Am J Obstet Gynecol MFM. 2021;3(5):100404. https://doi.org/10.1016/j.ajogmf.2021.100404
  29. Iqbal K, Iqbal A, Rathore SS, Ahmed J, Ali SA, Farid E, Hasanain M, Azeem Q, Qadar LT, Memon FR, Azim D. Risk factors for blood transfusion in Cesarean section: A systematic review and meta-analysis. Transfus Clin Biol. 2021:S1246-7820(21)00477-8.  https://doi.org/10.1016/j.tracli.2021.09.010
  30. Omotayo MO, Abioye AI, Kuyebi M, Eke AC. Prenatal anemia and postpartum hemorrhage risk: A systematic review and meta-analysis. J Obstet Gynaecol Res. 2021;47(8):2565-2576. https://doi.org/10.1111/jog.14834
  31. Ende HB, Lozada MJ, Chestnut DH, Osmundson SS, Walden RL, Shotwell MS, Bauchat JR. Risk Factors for Atonic Postpartum Hemorrhage: A Systematic Review and Meta-analysis. Obstet Gynecol. 2021 ;137(2): 305-323.  https://doi.org/10.1097/AOG.0000000000004228
  32. Kozek-Langenecker SA. Perioperative coagulation monitoring. Best Pract Res Clin Anaesthesiol. 2010;24(1):27-40.  https://doi.org/10.1016/j.bpa.2009.09.009
  33. Winter WE, Flax SD, Harris NS. Coagulation Testing in the Core Laboratory. Lab Med. 2017;48(4):295-313. 
  34. Lippi G, Adcock D, Simundic AM, Tripodi A, Favaloro EJ. Critical laboratory values in hemostasis: toward consensus. Ann Med. 2017;49(6):455-461. 
  35. Fenger-Eriksen C. Perioperative Coagulation Monitoring. Anesthesiol Clin. 2021;39(3):525-535. PMID: 34392883. https://doi.org/10.1016/j.anclin.2021.03.010
  36. Haas T, Fries D, Tanaka KA, Asmis L, Curry NS, Schochl H. Usefulness of standard plasma coagulation tests in the management of perioperative coag- ulopathic bleeding: is there any evidence? Br JAnaesth. 2015;114(2):217-224.  https://doi.org/10.1093/bja/aeu303
  37. Fenger-Eriksen C. Perioperative Coagulation Monitoring. Anesthesiol Clin. 2021;39(3):525-535.  https://doi.org/10.1016/j.anclin.2021.03.010
  38. Abuzeid AM, O’Keeffe T. Review of massive transfusion protocols in the injured, bleeding patient. Curr Opin Crit Care. 2019;25(6):661-667. PMID: 31574016. https://doi.org/10.1097/MCC.0000000000000668
  39. Vlaar AP, Oczkowski S, de Bruin S, Wijnberge M, Antonelli M, Aubron C, Aries P, Duranteau J, Juffermans NP, Meier J, Murphy GJ, Abbasciano R, Muller M, Shah A, Perner A, Rygaard S, Walsh TS, Guyatt G, Dionne JC, Cecconi M. Transfusion strategies in non-bleeding critically ill adults: A clinical practice guideline from the European Society of Intensive Care Medicine. Intensive Care Med. 2020;46(4):673-696.  https://doi.org/10.1007/s00134-019-05884-8
  40. Vlaar APJ, Dionne JC, de Bruin S, Wijnberge M, et al. Transfusion strategies in bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine. Intensive Care Med. 2021;47(12):1368-1392. https://doi.org/10.1007/s00134-021-06531-x
  41. Wada H, Matsumoto T, Yamashita Y, Hatada T. Disseminated intravascular coagulation: testing and diagnosis. Clin Chim Acta. 2014;436:130-134. Epub 2014 Apr 30. PMID: 24792730. https://doi.org/10.1016/j.cca.2014.04.020
  42. Toh CH, Hoots WK; SSC on Disseminated Intravascular Coagulation of the ISTH. The scoring system of the Scientific and Standardisation Committee on Disseminated Intravascular Coagulation of the International Society on Thrombosis and Haemostasis: a 5-year overview. J Thromb Haemost. 2007;5(3):604-606.  https://doi.org/10.1111/j.1538-7836.2007.02313.x
  43. Toh CH, Alhamdi Y, Abrams ST. Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular Coagulation. Ann Lab Med. 2016;36(6):505-512. Erratum in: Ann Lab Med. 2017;37(1):95. PMID: 27578502; PMCID: PMC5011102. https://doi.org/10.3343/alm.2016.36.6.505
  44. Amgalan A, Allen T, Othman M, Ahmadzia HK. Systematic review of viscoelastic testing (TEG/ROTEM) in obstetrics and recommendations from the women’s SSC of the ISTH. J Thromb Haemost. 2020;18(8):1813-1838. https://doi.org/10.1111/jth.14882
  45. De Lange NM, van Rheenen-Flach LE, Lance MD, Mooyman L, Woiski M, van Pampus EC, Porath M, Bolte AC, Smits L, Henskens YM, Scheepers HC. Peri-partum reference ranges for ROTEM(R) thromboelastometry. Br J Anaesth. 2014;112(5):852-859. Epub 2014 Jan 31. PMID: 24486836. https://doi.org/10.1093/bja/aet480
  46. Bugaev N, Como JJ, Golani G, Freeman JJ, Sawhney JS, Vatsaas CJ, York- gitis BK, Kreiner LA, Garcia NM, Aziz HA, Pappas PA, Mahoney EJ, Brown ZW, Kasotakis G. Thromboelastography and rotational thromboelastometry in bleeding patients with coagulopathy: Practice management guideline from the Eastern Association for the Surgery of Trauma. J Trauma Acute Care Surg. 2020;89(6):999-1017. https://doi.org/10.1097/TA.0000000000002944
  47. Ramler PI, Gillissen A, Henriquez DDCA, et al. Clinical value of early vis-coelastometric point-of-care testing during postpartum hemorrhage for the prediction of severity of bleeding: A multicenter prospective cohort study in the Netherlands. Acta Obstet Gynecol Scand. 2021;100(9):1656-1664. Epub 2021 Jun 19. PMID: 33999407; PMCID: PMC8453832. https://doi.org/10.1111/aogs.14172
  48. Shamshirsaz AA, Fox KA, Erfani H, et al. Trimester-specific thromboelastic values and coagulation activation markers in pregnancy compared across trimesters and compared to the nonpregnant state. Int J Lab Hematol. 2021;43(5):1216-1224. https://doi.org/10.1111/ijlh.13472
  49. Tanaka KA, Henderson RA, Strauss ER. Evolution of viscoelastic coagulation testing. Expert Rev Hematol. 2020;13(7):697-707.  https://doi.org/10.1080/17474086.2020.1758929
  50. Fahrendorff M, Oliveri RS, Johansson PI. The use of viscoelastic haemostatic assays in goal-directing treatment with allogeneic blood products — A systematic review and meta-analysis. Scand J Trauma Resusc Emerg Med. 2017;25(1):39.  https://doi.org/10.1186/s13049-017-0378-9
  51. Ronenson AM, Shifman EM, Kulikov AV, Raspopin YuS. Referensnye po- kazateli rotacionnoj tromboelastometrii u beremennyh i rozhenic: siste- maticheskij obzor i metaanaliz. Anesteziologiya i Reanimatologiya. 2021;3:28- 40. (In Russ.). https://doi.org/10.17116/anaesthesiology202103128
  52. Brill JB, Brenner M, Duchesne J, et al. The Role of TEG and ROTEM in Damage Control Resuscitation. Shock. 2021;56(1S):52-61.  https://doi.org/10.1097/SHK.0000000000001686
  53. Tsang YS, Kurniawan AR, Tomasek O, et al. Effects of rotational thromboelastometry-guid-ed transfusion management in patients undergoing surgical interven-tion for postpartum hemorrhage: An observational study. Transfusion. 2021;61(10):2898-2905. https://doi.org/10.1111/trf.16637
  54. Muller MCA, Meijers JC, van Meenen DM, Thachil J, Juffermans NP. Thromboelastometry in critically ill patients with disseminated intravascular coagulation. Blood Coagul Fibrinolysis. 2019;30(5):181-187.  https://doi.org/10.1097/MBC.0000000000000808
  55. Liew-Spilger AE, Sorg NR, Brenner TJ, et al. Viscoelastic Hemostatic Assays for Postpartum Hemorrhage. J Clin Med. 2021;10(17):3946. https://doi.org/10.3390/jcm10173946
  56. Erez O, Novack L, Beer-Weisel R, Duet al. DIC score in pregnant women — a population based modification of the International Society on Thrombosis and Hemostasis score. PLoS One. 2014;9(4):e93240. https://doi.org/10.1371/journal.pone.0093240
  57. Erez O. Disseminated intravascular coagulation in pregnancy — Clinical phenotypes and diagnostic scores. Thromb Res. 2017;151(Suppl 1):56-60.  https://doi.org/10.1016/S0049-3848(17)30069-5
  58. Rabinovich A, Abdul-Kadir R, Thachil J, Iba T, Othman M, Erez O. DIC in obstetrics: Diagnostic score, highlights in management, and international registry-communication from the DIC and Women’s Health SSCs ofthe International Society of Thrombosis and Haemostasis. J Thromb Hae-most. 2019;17(9):1562-1566. https://doi.org/10.nn/jth.14523
  59. Hizkiyahu R, Rabinovich A, Thachil J, Sheiner E, Shaked G, Sebbag G, Maymon E, Erez O. Modified ISTH pregnancy-specific DIC score in parturients with liver rupture: population-based case series. J Matern Fetal Neonatal Med. 2019;32(15):2517-2523. https://doi.org/10.1080/14767058.2018.1439469
  60. Lee DH, Lee BK, Jeung KW, Park JS, et al. Performance of 5 disseminated intravascular coagulation score systems in predicting mortality in patients with severe trauma. Medicine (Baltimore). 2018;97(33):e11912.
  61. Asakura H, Takahashi H, Uchiyama T, Eguchi Yet al. DIC subcommittee of the Japanese Society on Thrombosis and Hemostasis. Proposal for new diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis. Thromb J. 2016;14:42. 
  62. Wada H, Thachil J, Di Nisio M, Mathew P, et al. The Scientific Standardization Committee on DIC of the International Society on Thrombosis Haemostasis. Guidance for diagnosis and treatment of DIC from harmonization of the recommendations from three guidelines. J Thromb Haemost. 2013 Feb 04;42. 
  63. Thrombosis and hemostasis study group in hematology branch of the Chinese Medical Association.Chinese experts’ consensus on the diagnosis and treatment of disseminated intravascular coagulation (2012 edition). Chin J Hematol. 2012;33(11):978-979. 
  64. Saito S, Uchino S, Hayakawa M, Yamakawa K, et al. Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group. Epidemiology of disseminated intravascular coagulation in sepsis and validation of scoring systems. JCrit Care. 2018;50:23-30. 
  65. Liu Y, Li X, Che X, Zhao G, Xu M. Intraoperative cell salvage for obstetrics: a prospective randomized controlled clinical trial. BMC Pregnancy Childbirth. 2020;20(1):452.  https://doi.org/10.1186/s12884-020-03138-w
  66. Chen H, Tan H, Luo PX, Shen YF, et al. Comparison of cell salvage with one and two suction devices during cesarean section in patients with placenta previa and/or accrete: a randomized controlled trial. Chin Med J (Engl). 2020;133(6):638-643.  https://doi.org/10.1097/CM9.0000000000000699
  67. Omotayo MO, Abioye AI, Kuyebi M, Eke AC. Prenatal anemia and postpartum hemorrhage risk: A systematic review and meta-analysis. J Obstet Gynaecol Res. 2021;47(8):2565-2576. https://doi.org/10.1111/jog.14834
  68. Fowler AJ, Ahmad T, Phull MK, Allard S, et al. Meta-analysis of the association between preoperative anaemia and mortality after surgery. Br J Surg. 2015;102(11):1314-1324. https://doi.org/10.1002/bjs.9861
  69. Nair M, Chhabra S, Choudhury SS, Deka D, et al. MaatHRI collaborators. Relationship between anaemia, coagulation parameters during pregnancy and postpartum haemorrhage at childbirth: a prospective cohort study. BMJ Open. 2021;11(10):e050815. https://doi.org/10.1136/bmjopen-2021-050815
  70. Xie Y, Liang J, Mu Y, Liu Z, et al. Incidence, trends and risk factors for obstetric massive blood transfusion in China from 2012 to 2019: An observational study. BMJ Open. 2021;11(9):e047983. https://doi.org/10.1136/bmjopen-2020-047983
  71. Ochiai D, Abe Y, Yamazaki R, Uemura T, et al. Clinical Results of a Massive Blood Transfusion Protocol for Postpartum Hemorrhage in a University Hospital in Japan: A Retrospective Study. Medicina (Kaunas). 2021;57(9):983.  https://doi.org/10.3390/medicina57090983
  72. Munoz M, Stensballe J, Ducloy-Bouthors AS, Bonnet MP, et al. Patient blood management in obstetrics: prevention and treatment of postpartum haemorrhage. A NATA consensus statement. Blood Transfus. 2019;17(2): 112-136.  https://doi.org/10.2450/2019.0245-18
  73. American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins — Obstetrics. Anemia in Pregnancy: ACOG Practice Bulletin, Number 233. Obstet Gynecol. 2021;138(2):55-64.  https://doi.org/10.1097/AOG.0000000000004477
  74. Kroh S, Waters JH. Obstetrical Hemorrhage. Anesthesiol Clin. 2021;39(4): 597-611.  https://doi.org/10.1016/j.anclin.2021.08.009
  75. Jansen AJ, van Rhenen DJ, Steegers EA, Duvekot JJ. Postpartum hemorrhage and transfusion of blood and blood components. Obstet Gynecol Surv. 2005;60(10):663-671.  https://doi.org/10.1097/01.ogx.0000180909.31293.cf
  76. Weisel JW, Litvinov RI. Red blood cells: The forgotten player in hemostasis and thrombosis. J Thromb Haemost. 2019;17(2):271-282.  https://doi.org/10.1111/jth.14360
  77. Alamin AA. The Role of Red Blood Cells in Hemostasis. Semin Thromb He- most. 2021;47(1):26-31.  https://doi.org/10.1055/s-0040-1718889
  78. Gillespie AH, Doctor A. Red Blood Cell Contribution to Hemostasis. Front Pediatr. 2021;9:629824. https://doi.org/10.3389/fped.2021.629824
  79. Clark SL, Romero R, Dildy GA, Callaghan WM, et al. Proposed diagnostic criteria for the case definition of amniotic fluid embolism in research studies. Am J Obstet Gynecol. 2016;215(4):408-412. 
  80. Sommer N, Schnuriger B, Candinas D, Haltmeier T. Massive transfusion protocols in nontrauma patients: A systematic review and meta-analysis. J Trauma Acute Care Surg. 2019;86(3):493-504.  https://doi.org/10.1097/TA.0000000000002101
  81. Thomasson RR, Yazer MH, Gorham JD, Dunbar NM; MTP Use Study Investigators, on behalf of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative. International assessment of massive transfusion protocol contents and indications for activation. Transfusion. 2019;59(5):1637-1643. https://doi.org/10.1111/trf.15149
  82. Shih AW, Al Khan S, Wang AY, Dawe P, Young PY, Greene A, Hudoba M, Vu E. Systematic reviews of scores and predictors to trigger activation of massive transfusion protocols. J Trauma Acute Care Surg. 2019;87(3):717-729.  https://doi.org/10.1097/TA.0000000000002372
  83. Kolin DA, Shakur-Still H, Bello A, Chaudhri R, Bates I, Roberts I. Risk factors for blood transfusion in traumatic and postpartum hemorrhage patients: Analysis of the CRASH-2 and WOMAN trials. PLoS One. 2020;15(6):e0233274. https://doi.org/10.1371/journal.pone.0233274
  84. Ochiai D, Abe Y, Yamazaki R, Uemura T, Toriumi A, Matsuhashi H, Tanaka Y, Ikenoue S, Kasuga Y, Tanosaki R, Tanaka M. Clinical Results of a Massive Blood Transfusion Protocol for Postpartum Hemorrhage in a University Hospital in Japan: A Retrospective Study. Medicina (Kaunas). 2021;57(9):983.  https://doi.org/10.3390/medicina57090983
  85. Tanaka H, Matsunaga S, Yamashita T, Okutomi T, et al. A systematic review of massive transfusion protocol in obstetrics. Taiwan J Obstet Gynecol. 2017;56(6):715-718. 
  86. Prick BW, Jansen AJ, Steegers EA, et al. Transfusion policy after severe postpartum haemorrhage: A randomised non-inferiority trial. BJOG. 2014;121(8):1005-1014. https://doi.org/10.1111/1471-0528.12531
  87. Butwick AJ, Goodnough LT. Transfusion and coagulation management in major obstetric hemorrhage. Curr Opin Anaesthesiol. 2015;28(3):275-284.  https://doi.org/10.1097/ACO.0000000000000180
  88. Kozek-Langenecker SA, Ahmed AB, Afshari A, Albaladejo P, et al. Management of severe perioperative bleeding: guidelines from the European Society ofAnaesthesiology: First update 2016. Eur JAnaesthesiol. 2017;34(6):332-395.  https://doi.org/10.1097/EJA.0000000000000630
  89. Committee on Practice Bulletins-Obstetrics. Practice Bulletin No. 183: Postpartum Hemorrhage. Obstet Gynecol. 2017;130(4):168-186.  https://doi.org/10.1097/AOG.0000000000002351
  90. Gatta LA, Lockhart EL, James AH. Blood Products in the Management of Abnormal Placentation. Clin Obstet Gynecol. 2018;61(4):828-840.  https://doi.org/10.1097/GRF.0000000000000400
  91. O’Brien KL, Shainker SA, Lockhart EL. Transfusion Management of Obstetric Hemorrhage. Transfus Med Rev. 2018;32(4):249-255. 
  92. Lier H, von Heymann C, Korte W, Schlembach D. Peripartum Haemorrhage: Haemostatic Aspects of the New German PPH Guideline. Transfus Med Hemother. 2018;45(2):127-135. 
  93. Salmanian B, Clark SL, Hui SR, Detlefs S, Aalipour S, Meshinchi Asl N, Shamshirsaz AA. Massive Transfusion Protocols in Obstetric Hemorrhage: Theory versus Reality. Am J Perinatol. 2021 May 14.  https://doi.org/10.1055/s-0041-1728833
  94. Brenner A, Shakur-Still H, Chaudhri R, Fawole B, Arulkumaran S, Roberts I; WOMAN Trial Collaborators. The impact of early outcome events on the effect of tranexamic acid in postpartum haemorrhage: An exploratory subgroup analysis of the WOMAN trial. BMC Pregnancy Childbirth. 2018;18(1):215.  https://doi.org/10.1186/s12884-018-1855-5-
  95. Ageron A, Prieto-Merino D, Ker K, Shakur H, et al. Antifibrinolytic Trials Collaboration. Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: A meta-analysis of individual patient-level data from 40 138 bleeding patients. Lancet.2018;391(10116):125-132.  https://doi.org/10.1016/S0140-6736(17)32455-8
  96. Aziz S, Rossiter S, Homer CSE, Wilson AN, Comrie-Thomson L, Scott N, Vogel JP. The cost-effectiveness of tranexamic acid for treatment of postpartum hemorrhage: A systematic review. Int J Gynaecol Obstet 2021;155(3):331-344.  https://doi.org/10.1002/ijgo.13654
  97. Della Corte L, Saccone G, Locci M, Carbone L, Raffone A, Giampaolino P, Ciardulli A, Berghella V, Zullo F. Tranexamic acid for treatment of primary postpartum hemorrhage after vaginal delivery: A systematic review and meta-analysis of randomized controlled trials. J Matern Fetal Neonatal Med. 2020;33(5):869-874.  https://doi.org/10.1080/14767058.2018.1500544
  98. Fahrenholtz CG, Bonanno LS, Martin JB. Tranexamic acid as adjuvant treatment for postpartum hemorrhage: a systematic review protocol. JBI Database System Rev Implement Rep. 2019;17(8):1565-1572. https://doi.org/10.n124/JBISRIR-2017-003978
  99. Picetti R, Miller L, Shakur-Still H, Pepple T, Beaumont D, Balogun E, Asonganyi E, Chaudhri R, El-Sheikh M, Vwalika B, Arulkumaran S, Roberts I; WOMAN trial collaborators. The WOMAN trial: clinical and contextual factors surrounding the deaths of 483 women following post-partum haemorrhage in developing countries. BMC Pregnancy Childbirth. 2020;20(1):409.  https://doi.org/10.1186/s12884-020-03091-8
  100. A Comprehensive Textbook of Postpartum Hemorrhage An Essential Clinical Reference for Effective Management. 2nd ed. Arulkumaran S, Karoshi M, Keith LG, Lalondh AB, B-Lynch C, eds. The Global Library of Women’ Medlclne-Saplens Publlshln; 2012:654. 
  101. Prevention and Management of Postpartum Haemorrhage: Green-top Guideline No. 52. BJOG. 2017;124(5):106-149. 
  102. Henriquez DDCA, Bloemenkamp KWM, van der Bom JG. Management of postpartum hemorrhage: how to improve maternal outcomes? J Thromb Haemost. 2018 June 08. 
  103. Rani PR, Begum J. Recent Advances in the Management of Major Postpartum Haemorrhage — A Review. J Clin Dlagn Res. 2017;11(2):01-05. 
  104. Haumonth JB, Sentilhes L, Mach P, Cravello L, et al. Surgical treatment of postpartum hemorrhage. J Gynecol Obstet Biol Reprod (Paris). 2014;43(10):1083-1103.
  105. Woods TN, Scott KR, Quick JA. New Advances in the Care of the Hemorrhaging Patient. Mo Med. 2018;115(5):434-437. 
  106. Doumouchtsis SK, Papageorghiou AT, Arulkumaran S. Systematic review of conservative management of postpartum hemorrhage: what to do when medical treatment fails. Obstet Gynecol Surv. 2007;62(8):540-547.  https://doi.org/10.1097/01.ogx.0000271137.81361.93
  107. Kellie FJ, Wandabwa JN, Mousa HA, Weeks AD. Mechanical and surgical interventions for treating primary postpartum haemorrhage. Cochrane Database Syst Rev. 2020;7(7):CD013663. https://doi.org/10.1002/14651858.CD013663
  108. Tanaka KA, Shettar S, Vandyck K, Shea SM, Abuelkasem E. Roles of Four-Factor Prothrombin Complex Concentrate in the Management of Critical Bleeding. Transfus Med Rev. 2021;35(4):96-103.  https://doi.org/10.1016/j.tmrv.2021.06.007
  109. Erdoes G, Koster A, Ortmann E, Meesters MI, Bolliger D, Baryshnikova E, Martinez Lopez De Arroyabe B, Ahmed A, Lance MD, Ranucci M, von Heymann C, Agarwal S, Ravn HB. A European consensus statement on the use of four-factor prothrombin complex concentrate for cardiac and noncardiac surgical patients. Anaesthesia. 2021;76(3):381-392.  https://doi.org/10.1111/anae.15181
  110. Karkouti K, Bartoszko J, Grewal D, Bingley C, Armali C, Carroll J, Hucke HP, Kron A, McCluskey SA, Rao V, Callum J. Comparison of 4-Factor Prothrombin Complex Concentrate With Frozen Plasma for Management of Hemorrhage During and After Cardiac Surgery: A Randomized Pilot Trial. JAMA Netw Open. 2021;4(4):e213936. https://doi.org/10.1001/jamanetworkopen.2021.3936
  111. Huang WT, Cang WC, Derry KL, Lane JR, von Drygalski A. Four- Factor Prothrombin Complex Concentrate for Coagulopathy Reversal in Patients With Liver Disease. Clin Appl Thromb Hemost. 2017;23(8):1028-1035. https://doi.org/10.1177/1076029616668406
  112. Franchini M, Franchi M, Bergamini V, Montagnana M, Salvagno GL, Targher G, Lippi G. The use of recombinant activated FVII in postpartum hemorrhage. Clin Obstet Gynecol. 2010;53(1):219-227. PMID: 20142658. https://doi.org/10.1097/GRF.0b013e3181cc4378
  113. American Society of Anesthesiologists Task Force on Perioperative Blood Management. Practice guidelines for perioperative blood management: An updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Management. Anesthesiology. 2015;122(2):241-275. 
  114. Kozek-Langenecker SA, Ahmed AB, Afshari A, Albaladejo P, et al. Manage-ment of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology: First update 2016. Eur J Anaesthesiol. 2017;34(6):332-395. 
  115. Collins P, Abdul-Kadir R, Thachil J; Subcommittees on Women’ s Health Issues in Thrombosis and Haemostasis and on Disseminated Intravascu-lar Coagulation. Management of coagulopathy associated with postpartum hemorrhage: guidance from the SSC of the ISTH. J Thromb Haemost. 2016;14(1):205-210. 
  116. Shaylor R, Weiniger CF, Austin N, Tzabazis A, et al. National and International Guidelines for Patient Blood Management in Obstetrics: A Qualitative Review. Anesth Analg. 2017;124(1):216-232. 
  117. Knight M, Fitzpatrick K, Kurinczuk JJ, Tuffnell D. Use of recombinant factor VIIa in patients with amniotic fluid embolism. Anesthesiology. 2012;117:423. 
  118. Green L, Roberts N, Platton S, et al. Impact of prothrombin complex concentrate and fresh frozen plasma on correction of haemostatic abnormalities in bleeding patients undergoing cardiac surgery (PROPHESY trial results). Anaesthesia. 2021;76(7):997-1000. https://doi.org/10.1111/anae.15395
  119. Lance MD, Ranucci M, von Heymann C, Agarwal S, Ravn HB. A European consensus statement on the use of four-factor prothrombin complex concentrate for cardiac and non-cardiac surgical patients. Anaesthesia. 2021;76(3):381-392.  https://doi.org/10.1111/anae.15181
  120. Shah A, Palmer AJR, Klein AA. Strategies to minimize intraoperative blood loss during major surgery. Br JSurg. 2020;107(2):26-38.  https://doi.org/10.1002/bjs.11393. PMID: 31903592
  121. Feih JT, Juul JJ, G Rinka JR, et al. Adequacy of hemostatic resuscitation improves therapeutic efficacy of recombinant activated factor VII and reduces reexploration rate for bleeding in postoperative cardiac surgery patients with refractory hemorrhage. Ann Card Anaesth. 2019;22(4):388-393.  https://doi.org/10.4103/aca.ACA_108_18
  122. Shayeb AM, Li C, Kang G, Reiss UM, Elbahlawan L. Use of recombinant activated factor VII for uncontrolled bleeding in a haematology/ oncology paediatric ICU cohort. Blood Coagul Fibrinolysis. 2020;31(7):440-444.  https://doi.org/10.1097/MBC.0000000000000942
  123. Katz A, Ahuja T, Arnouk S, Let al. A Comparison of Prothrombin Complex Concentrate and Recombinant Activated Factor VII for the Management of Bleeding With Cardiac Surgery. J Intensive Care Med. 2022 Feb;37(2):231-239.  https://doi.org/10.1177/0885066620984443.
  124. Shaylor R, Weiniger CF, Austin N, et al. National and International Guidelines for Patient Blood Management in Obstetrics: A Qualitative Review. Anesth Analg. 2017;124(1):216-232. 2021 Jan 05:885066620984443. https://doi.org/10.1177/0885066620984443
  125. Saccone G, Della Corte L, et al. Prophylactic use of tranexamic acid after vaginal delivery reduces the risk of primary postpartum hemorrhage. J Matern Fetal Neonatal Med. 2020;33(19):3368-3376. https://doi.org/10.1080/14767058.2019.1571576
  126. Stortroen NE, Tubog TD, Shaffer SK. Prophylactic Tranexamic Acid in High-Risk Patients Undergoing Cesarean Delivery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. AANA J. 2020;88(4):273-281. 
  127. Wang Y, Liu S, He L. Prophylactic use of tranexamic acid reduces blood loss and transfusion requirements in patients undergoing cesarean section: A meta-analysis. J Obstet Gynaecol Res.2019;45(8):1562-1575.
  128. Masuzawa Y, Kataoka Y, Fujii K, Inoue S. Prophylactic management of postpartum haemorrhage in the third stage of labour: an overview of systematic reviews. Syst Rev. 2018;7(1):156.  https://doi.org/10.1186/s13643-018-0817-3
  129. Li C, Gong Y, Dong L, Xie B, Dai Z. Is prophylactic tranexamic acid administration effective and safe for postpartum hemorrhage prevention?: A systematic review and meta-analysis. Medicine (Baltimore). 2017;96(1):e5653. https://doi.org/10.1097/MD.0000000000005653
  130. Hahn RG. Adverse effects of crystalloid and colloid fluids. Anaesthesiol Intensive Ther. 2017;49(4):303-308.  https://doi.org/10.5603/AIT.a2017.0045
  131. Gillissen A, van den Akker T, Caram-Deelder C, et al. Association between fluid management and dilutional coagulopathy in severe postpartum haemorrhage: a nationwide retrospective cohort study. BMC Pregnancy Childbirth. 2018;18(1):398. Published 2018 Oct 11.  https://doi.org/10.1186/s12884-018-2021-9
  132. Henriquez DDCA, Bloemenkamp KWM, Loeff RM, et al. Fluid resuscitation during persistent postpartum haemorrhage and maternal outcome: A nationwide cohort study. Eur J Obstet Gynecol Reprod Biol. 2019;235:49-56.  https://doi.org/10.1016/j.ejogrb.2019.01.027
  133. Getrajdman C, Sison M, Lin HM, Katz D. The impact of crystalloid versus colloid on coagulation as measured by thromboelastometry in term parturients: an in vitro study. JMatern Fetal Neonatal Med. 2021:1-8. Epub ahead of print. PMID: 34015981. https://doi.org/10.1080/14767058.2021.1929157
  134. Boyd CJ, Brainard BM, Smart L. Intravenous Fluid Administration and the Coagulation System. Front Vet Sci. 2021;8:662504. https://doi.org/10.3389/fvets.2021.662504
  135. Schol PBB, de Lange NM, Woiski MD, Langenveld J, Smits LJM, Wassen MM, Henskens YM, Scheepers HCJ. Restrictive versus liberal fluid resuscitation strategy, influence on blood loss and hemostatic parameters in mild obstetric hemorrhage: An open-label randomized controlled trial. (REFILL study). PLoS One. 2021;16(6):e0253765. https://doi.org/10.1371/journal.pone.0253765
  136. Sevcikova S, Vymazal T, Durila M. Effect of Balanced Crystalloid, Gelatin and Hydroxyethyl Starch on Coagulation Detected by Rotational Thromboelastometry In Vitro. Clin Lab. 2017;63(10):1691-1700. https://doi.org/10.7754/Clin.Lab.2017.170505
  137. Bogert JN, Harvin JA, Cotton BA. Damage Control Resuscitation. J Intensive Care Med. 2016;31(3):177-186.  https://doi.org/10.1177/0885066614558018
  138. Spahn DR, Bouillon B, Cerny V, Duranteau J, Filipescu D, Hunt BJ, Komadina R, Maegele M, Nardi G, Riddez L, Samama CM, Vincent JL, Rossaint R. The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition. Crit Care. 2019;23(1):98.  https://doi.org/10.1186/s13054-019-2347-3
  139. Rasmussen KC, Johansson PI, Hrnjskov M, et al. Hydroxyethyl starch reduces coagulation competence and increases blood loss during major surgery: results from a randomized controlled trial. Ann Surg. 2014;259(2):249-254.  https://doi.org/10.1097/SLA.0000000000000267
  140. Hammad Y, Elmoghazy W, El Ansari W, Lance M, Zaghw A, Shallik N. Ex-perimental effect of different dilutions of blood with human plasma protein fraction and large dose factor one on blood coagulation and chemistry in vitro. Indian JAnaesth. 2019;63(12):1015-1021. https://doi.org/10.4103/ija.IJA_398_19
  141. Moore HB, Tessmer MT, Moore EE, Sperry JL, Cohen MJ, Chapman MP, Pusateri AE, Guyette FX, Brown JB, Neal MD, Zuckerbraun B, Sauaia A. Forgot calcium? Admission ionized calcium in two civilian randomized controlled trials of prehospital plasma for traumatic hemorrhagic shock. J Trauma Acute Care Surg. 2020;88(5):588-596.  https://doi.org/10.1097/TA.0000000000002614
  142. Byerly S, Inaba K, Biswas S, Wang E, Wong MD, Shulman I, Benjamin E, Lam L, Demetriades D. Transfusion-Related Hypocalcemia After Trauma. World J Surg. 2020;44(11):3743-3750.
  143. Chanthima P, Yuwapattanawong K, Thamjamrassri T, Nathwani R, Stans- bury LG, Vavilala MS, Arbabi S, Hess JR. Association Between Ionized Calcium Concentrations During Hemostatic Transfusion and Calcium Treatment With Mortality in Major Trauma. Anesth Analg. 2021;132(6):1684-1691. https://doi.org/10.1213/ANE.0000000000005431
  144. Chung HS, Cho SJ, Park CS. Effects of liver function on ionized hypocal- caemia following rapid blood transfusion. JInt Med Res. 2012;40(2):572-582.  https://doi.org/10.1177/147323001204000219
  145. Napolitano LM. Hemostatic defects in massive transfusion: An update and treatment recommendations. Expert Rev Hematol. 2021;14(2):219-239. Epub 2021 Jan 6. PMID: 33267678. https://doi.org/10.1080/17474086.2021.1858788
  146. Ditzel RM Jr, Anderson JL, Eisenhart WJ, Rankin CJ, DeFeo DR, Oak S, Siegler J. A review of transfusion- and trauma-induced hypocalcemia: Is it time to change the lethal triad to the lethal diamond? J Trauma Acute Care Surg. 2020;88(3):434-439. 
  147. Hall C, Nagengast AK, Knapp C, Behrens B, Dewey EN, Goodman A, Bommiasamy A, Schreiber M. Massive transfusions and severe hypocalcemia: An opportunity for monitoring and supplementation guidelines. Transfusion. 2021;61(suppl 1):188-194.  https://doi.org/10.1111/trf.16496
  148. Rajagopalan S, Mascha E, Na J, Sessler DI. The effects of mild perioperative hypothermia on blood loss and transfusion requirement. Anesthesiology. 2008;108(1):71-77. PMID: 18156884. https://doi.org/10.1097/01.anes.0000296719.73450.52
  149. Alam HB, Pusateri AE, Kindzelski A, Egan D, et al. HYPOSTAT workshop participants. Hypothermia and hemostasis in severe trauma: A new crossroads workshop report. J Trauma Acute Care Surg. 2012;73(4):809-817. PMID: 23026915. https://doi.org/10.1097/TA.0b013e318265d1b8
  150. Wang CH, Chen NC, Tsai MS, Yu PH, et al. Therapeutic Hypothermia and the Risk of Hemorrhage: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Medicine (Baltimore). 2015;94(47):e2152. https://doi.org/10.1097/MD.0000000000002152
  151. Simegn GD, Bayable SD, Fetene MB. Prevention and management of perioperative hypothermia in adult elective surgical patients: A systematic review. Ann Med Surg (Lond). 2021;72:103059. https://doi.org/10.10167j.amsu.2021.103059
  152. Harvey CJ. Evidence-Based Strategies for Maternal Stabilization and Rescue in Obstetric Hemorrhage. AACNAdv Crit Care. 2018;29(3):284-294.  https://doi.org/10.4037/aacnacc2018966
  153. Kander T, Schott U. Effect of hypothermia on haemostasis and bleeding risk: A narrative review. J Int Med Res. 2019;47(8):3559-3568. https://doi.org/10.1177/0300060519861469
  154. Pacagnella RC, Borovac-Pinheiro A. Assessing and managing hypovolemic shock in puerperal women. Best Pract Res Clin Obstet Gynaecol. 2019;61: 89-105.  https://doi.org/10.1016/j.bpobgyn.2019.05.012
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.