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Gurskaya V.I.

Almazov National Medical Research Center

Dryagina N.V.

Almazov National Medical Research Center

Ivanov V.P.

Almazov National Medical Research Center

Aleksandrovich Yu.S.

Children’s Scientific Clinical Center for Infectious Diseases

Khachatryan V.A.

Almazov National Medical Research Center

Savvina I.A.

Polenov Neurosurgical Institute;
Mechnikov North-West State Medical University

Effect of general anesthesia on systemic inflammatory response and neuronal damage in children with craniosynostosis in perioperative period

Authors:

Gurskaya V.I., Dryagina N.V., Ivanov V.P., Aleksandrovich Yu.S., Khachatryan V.A., Savvina I.A.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2021;(1): 39‑45

DOI: 10.17116/anaesthesiology202101139

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Table of contents

EFFECT OF GENERAL ANESTHESIA ON SYSTEMIC INFLAMMATORY RESPONSE AND NEURONAL DAMAGE IN CHILDREN WITH CRANIOSYNOSTOSIS IN PERIOPERATIVE PERIOD
EFFECT OF GENERAL ANESTHESIA ON SYSTEMIC INFLAMMATORY RESPONSE AND NEURONAL DAMAGE IN CHILDREN WITH CRANIOSYNOSTOSIS IN PERIOPERATIVE PERIOD

To cite this article:

Gurskaya VI, Dryagina NV, Ivanov VP, Aleksandrovich YuS, Khachatryan VA, Savvina IA. Effect of general anesthesia on systemic inflammatory response and neuronal damage in children with craniosynostosis in perioperative period. Russian Journal of Anesthesiology and Reanimatology. 2021;(1):39‑45. (In Russ.)
https://doi.org/10.17116/anaesthesiology202101139

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Abstract:

OBJECTIVE

To study the effect of inhalation anesthesia with sevoflurane and intravenous anesthesia with propofol on systemic inflammatory response and neuronal damage in children with craniosynostosis using proinflammatory (IL 6, IL 8, TNFα) and anti-inflammatory (IL 10) cytokines, as well as serum s100B protein.

MATERIAL AND METHODS

There were 38 patients aged 1-18 months with non-syndromic forms of craniosynostosis, who underwent MRI of the brain anesthesia with sevoflurane (n=23) and sedation with propofol (n=15). Blood sampling was performed before the agent injection and immediately after its exposure.

RESULTS

In all patients, mean duration of exposure to sevoflurane (27.39±5.61 min) and propofol (29±4.93 min) was similar. Anesthesia with sevoflurane 2.0-2.5 vol.% was followed by significant increase in serum cytokine IL 6 (p=0.034577 and p=0.045108, respectively) and neurospecific protein s100B (p=0.045047).

CONCLUSION

Short-term exposure to sevoflurane and propofol without surgical stimulation causes systemic inflammatory response with significant increase in serum IL 6. An increased level of neurospecific protein s100B after short-term exposure to sevoflurane 2.0-2.5 vol.% without surgical stimulation demonstrates an activation of neuronal apoptosis in pediatric patients with craniosynostosis.

Keywords:

anesthesia
sevoflurane
propofol
pediatrics
systemic inflammatory response
neuroapoptosis
neurosurgery
craniosynostosis

Authors:

Gurskaya V.I.

Almazov National Medical Research Center

Dryagina N.V.

Almazov National Medical Research Center

Ivanov V.P.

Almazov National Medical Research Center

Aleksandrovich Yu.S.

Children’s Scientific Clinical Center for Infectious Diseases

Khachatryan V.A.

Almazov National Medical Research Center

Savvina I.A.

Polenov Neurosurgical Institute;
Mechnikov North-West State Medical University

Received:

23.10.2020

Accepted:

18.11.2020

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