Resuscitation and intensive care in acute massive blood loss in adults (clinical guidelines)

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Massive blood loss remains one of the most pressing problems for the entire sphere of medicine in critical conditions. This pathology is difficult both in terms of approaches to intensive care and in relation to complications arising from this therapy. The clinical recommendations set forth modern ideas about the features of resuscitation and intensive care of acute massive blood loss in adult patients.

Keywords:

blood loss

shock

coagulopathy

hemodynamics

transfusion

Authors:

Grigor'ev E.V.

kafedra anesteziologii i reanimatologii Kemerovskoĭ gosudarstvennoĭ meditsinskoĭ akademii

ORCID: 0000-0001-8370-3083

Lebedinskii K.M.

FGBOU VO «North-West State Medical University named after I.I. Mechnikov» Ministry of Health of Russia, St. Petersburg, Russia

SPIN RSCI: 3590-2308
Scopus AuthorID: 6602775085
ResearcherID: O-8655-2014
ORCID: 0000-0002-5752-4812

Schegolev A.V.

N.N. Burdenko Main Military Clinical Hospital, Moscow, Russia ,SM Kirov Military Medical Academy, St. Petersburg, Russia

SPIN RSCI: 4107-6860
Scopus AuthorID: 7003338841
ResearcherID: J-4326-2013
ORCID: 0000-0001-6431-439X

Bobovnik S.V.

Northern State Medical University under the Ministry of Health of the Russia;
Arkhangelsk, Russia, 163000

Bulanov A.Yu.

St. Petersburg, Russia

Zabolotskikh I.B.

FGBOU VO «Kuban State Medical University» Ministry of Health of Russia, Krasnodar, Russia

SPIN RSCI: 5142-1661
Scopus AuthorID: 6508104506
ResearcherID: O-2705-2014
ORCID: 0000-0002-3623-2546

Sinkov S.V.

Kuban State Medical University, Krasnodar, Russia;
Regional Clinical Hospital №2, Krasnodar, Russia

SPIN RSCI: 4413-0869
Scopus AuthorID: 57218212478
ORCID: 0000-0003-4483-4077

Shen N.P.

Federal State Budgetary Educational Institution of Higher Education 'Tyumen State Medical University' of the Ministry of Healthcare of the Russian Federation, Russia, 625023, Tyumen, 625023, ul. Odesskaya, 54

Kornelyuk R.A.

Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases, Russia, Kemerovo, 650002, Sosnoviy blvd, 6

List of references:

Klein AA, Arnold P, Bingham RM, Brohi K, Clark R, Collis R, Gill R, McSporran W, Moor P, Rao Baikady R, Richards T, Shinde S, Stanworth S, Walsh TS. AAGBI guidelines: the use of blood components and their alternatives 2016. Anaesthesia. 2016;71(7):829-842. https://doi.org/10.1111/anae.13489
Mitra B, Mori A, Cameron PA, Fitzgerald M, Street A, Bailey M. Massive blood transfusion and trauma resuscitation. Injury. 2007;38(9):1023-1029.
Mitra B, Mori A, Cameron PA, Fitzgerald M, Paul E, Street A. Fresh frozen plasma (FFP) use during massive blood transfusion in trauma resuscitation. Injury. 2010;41(1):35-39. https://doi.org/10.1016/j.injury.2009.09.029
Como JJ, Dutton RP, Scalea TM, Edelman BB, Hess JR. Blood transfusion rates in the care of acute trauma. Transfusion. 2004;44(6):809-813.
Brohi K, Singh J, Hern M, Coats T. Acute traumatic coagulopathy. Journal of Trauma. 2003;54(6):1127-1130.
Hess JR, Brohi K, Dutton RP, Hauser CJ, Holcomb JB, Kluger Y, Mackway-Jones K, Parr MJ, Rizoli SB, Yukioka T, Hoyt DB, Bouillon B. The coagulopathy of trauma: a review of mechanisms. The Journal of Trauma. 2008;65(4):748-754. https://doi.org/10.1097/TA.0b013e3181877a9c
Evans JA, van Wessem KJ, McDougall D, Lee KA, Lyons T, Balogh ZJ. Epidemiology of traumatic deaths: comprehensive population-based assessment. World Journal of Surgery. 2010;34(1):158-163. https://doi.org/10.1007/s00268-009-0266-1
Schoeneberg C, Schilling M, Hussmann B, Schmitz D, Lendemans S, Ruchholtz S. Preventable and potentially preventable deaths in severely injured patients: a retrospective analysis including patterns of errors. European Journal of Trauma and Emergency Surgery. 2017;43:481-489.
Morse BC, Dente CJ, Hodgman EI, Shaz BH, Winkler A, Nicholas JM, Wyrzykowski AD, Rozycki GS, Feliciano DV. Outcomes after massive transfusion in nontrauma patients in the era of damage control resuscitation. The American Surgeon. 2012;78(6):679-684.
Maegele M, Lefering R, Yucel N, Tjardes T, Rixen D, Paffrath T, Simanski C, Neugebauer E, Bouillon B; AG Polytrauma of the German Trauma Society (DGU). Early coagulopathy in multiple injury: analysis from the German Trauma Registry on 8724 patients. Injury. 2007;38:298-304.
Cannon JW. Hemorrhagic Shock. New England Journal of Medicine 2018;378:370-379. https://doi.org/10.1056/NEJMra1705649
Callum JL, Nascimento B, Alam A. Massive haemorrhage protocol: what’s the best protocol? ISBT Science Series. 2016;11(suppl 1):297-306.
Maegele M, Schochl H, Cohen MJ. An update on the coagulopathy of trauma. Shock. 2014;41(suppl 1):21-25.
Schlichtig R, Kramer DJ, Pinsky MR. Flow distribution during progressive hemorrhage is a determinat of critical O2 delivery. Journal of Applied Physiology. 1991;70:169-178.
Moroz VV, Ryzhkov IA. Ostraya krovopoterya: regionarnyi krovotok i mikrotsirkulyatsiya. Obshchaya reanimatologiya. 2016;12(5):65-94.
Bonanno FG. Physiopathology of shock. Journal of Emergencies, Trauma and Shock. 2011;4(2):222-232.
Barbee RW, Reynolds PS, Ward KR. Assessing shock resuscitation strategies by oxygen debt repayment. Shock. 2010;33:113-122.
Nelson DP, King CE, Dodd SL, Schumacker PT, Cain SM. Systemic and intestinal limits of O2 extraction in the dog. Journal of Applied Physiology. 1987;63:387-394.
Boutilier RG. Mechanisms of cell survival in hypoxia and hypothermia. Journal of Experimental Biology. 2001;204:3171-3181.
DeLoughery TG. Coagulation defects in trauma patients: etiology, recognition, and therapy. Critical Care Clinics. 2004;20(1):13-24.
Ganter MT, Pittet JF. New insights into acute coagulopathy in trauma patients. Best Practice and Research. Clinical Anaesthesia. 2010;24:15-25.
White NJ, Ward KR, Pati S, Strandenes G, Cap AP. Hemorrhagic blood failure: oxygen debt, coagulopathy, and endothelial damage. Journal of Trauma and Acute Care Surgery. 2017;82(suppl 1):41-49. https://doi.org/10.1097/TA.0000000000001436
Chang R, Cardenas JC, Wade CE, Holcomb JB. Advances in the understanding of trauma-induced coagulopathy. Blood. 2016;128:1043-1049.
Moore HB, Moore EE, Liras IN, Gonzalez E, Harvin JA, Holcomb JB, Sauaia A, Cotton BA. Acute fibrinolysis shutdown after injury occurs frequently and increases mortality: a multicenter evaluation of 2,540 severely injured patients. Journal of the American College of Surgeons. 2016;222:347-55. https://doi.org/10.1016/j.jamcollsurg.2016.01.006
Esmon CT. The protein C pathway. Chest. 2003;124(3 suppl):26-32.
Rezaie AR. Vitronectin functions as a cofactor for rapid inhibition of activated protein C by plasminogen activator inhibitor-1. Implications for the mechanism of profibrinolytic action of activated protein C. The Journal of Biological Chemistry. 2001;276:15567-15570.
Becker BF, Chappell D, Bruegger D, Annecke T, Jacob M. Therapeutic strategies targeting the endothelial glycocalyx: acute deficits, but great potential. Cardiovascular Research. 2010;87:300-310. https://doi.org/10.1093/cvr/cvq137
Chappell D, Dorfler N, Jacob M, Rehm M, Welsch U, Conzen P, Becker BF. Glycocalyx protection reduces leukocyte adhesion after ischemia/reperfusion. Shock. 2010;34(2):133-139. https://doi.org/10.1097/SHK.0b013e3181cdc363
Ostrowski SR, Johansson PI. Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy. Journal of Trauma and Acute Care Surgery. 2012;73:60-66.
Ostrowski SR, Henriksen HH, Stensballe J, Gybel-Brask M, Cardenas JC, Baer LA, Cotton BA, Holcomb JB, Wade CE, Johansson PI. Sympathoadrenal activation and endotheliopathy are drivers of hypocoagulability and hyperfibrinolysis in trauma: A prospective observational study of 404 severely injured patients. Journal of Trauma and Acute Care Surgery. 2017;82:293-301. https://doi.org/10.1097/TA.0000000000001304
Giamarellos-Bourboulis EJ, Kanellakopoulou K, Pelekanou A, Tsaganos T, Kotzampassi K. Kinetics of angiopoietin-2 in serum of multi-trauma patients: correlation with patient severity. Cytokine. 2008;44(2):310-313. https://doi.org/10.1016/j.cyto.2008.09.003
Brohi K, Cohen MJ, Ganter MT, Schultz MJ, Levi M, Mackersie RC, Pittet JF. Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. The Journal of Trauma. 2008;64(5):1211-1217. https://doi.org/10.1097/TA.0b013e318169cd3c
Cotton BA, Gunter OL, Isbell J, Au BK, Robertson AM, Morris JA Jr, St Jacques P, Young PP. Damage control hematology: the impact of a trauma exsanguination protocol on survival and blood product utilization. The Journal of Trauma. 2008;64(5):1177-1182.
Martini WZ. Coagulopathy by hypothermia and acidosis: mechanisms of thrombin generation and fibrinogen availability. The Journal of Trauma. 2009;67:202-208.
Furie B, Furie BC. Thrombus formation in vivo. Journal of Clinical Investigation. 2005;115:3355-3362.
Lier H, Krep H, Schroeder S, Stuber F. Preconditions of hemostasis in trauma: a review. The influence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma. The Journal of Trauma. 2008;65:951-960.
Vivien B, Langeron O, Morell E, Devilliers C, Carli PA, Coriat P, Riou B. Early hypocalcemia in severe trauma. Critical Care Medicine. 2005;33:1946-1952.
Martin M, Oh J, Currier H, Tai N, Beekley A, Eckert M, Holcomb J. An analysis of in-hospital deaths at a modern combat support hospital. The Journal of Trauma. 2009;66(4 suppl):51-60. https://doi.org/10.1097/TA.0b013e31819d86ad
Smith W, Williams A, Agudelo J, Shannon M, Morgan S, Stahel P, Morgan S, Stahel P, Moore E. Early predictors of mortality in hemodynamically unstable pelvis fractures. Journal of Orthopaedic and Traumatology. 2007;21(1):31-37.
Mayglothling J, Duane TM, Gibbs M, McCunn M, Legome E, Eastman AL, Whelan J, Shah KH; Eastern Association for the Surgery of Trauma. Emergency tracheal intubation immediately following traumatic injury: an Eastern Association for the Surgery of Trauma practice management guideline. Journal of Trauma and Acute Care Surgery. 2012;73(5 suppl 4):333-340. https://doi.org/10.1097/TA.0b013e31827018a5
Bernard SA, Nguyen V, Cameron P, Masci K, Fitzgerald M, Cooper DJ, Walker T, Std BP, Myles P, Murray L, David, Taylor, Smith K, Patrick I, Edington J, Bacon A, Rosenfeld JV, Judson R. Prehospital rapid sequence intubation improves functional outcome for patients with severe traumatic brain injury: a randomized controlled trial. Annals of Surgery. 2010;252(6):959-965. https://doi.org/10.1097/SLA.0b013e3181efc15f
Jeremitsky E, Omert L, Dunham CM, Protetch J, Rodriguez A. Harbingers of poor outcome the day after severe brain injury: hypothermia, hypoxia, and hypoperfusion. The Journal of Trauma. 2003;54(2):312-319.
Chi JH, Knudson MM, Vassar MJ, McCarthy MC, Shapiro MB, Mallet S, Holcroft JJ, Moncrief H, Noble J, Wisner D, Kaups KL, Bennick LD, Manley GT. Prehospital hypoxia affects outcome in patients with traumatic brain injury: a prospective multicenter study. The Journal of Trauma. 2006;61(5):1134-1141.
Damiani E, Adrario E, Girardis M, Romano R, Pelaia P, Singer M, Donati A. Arterial hyperoxia and mortality in critically ill patients: a systematic review and meta-analysis. Critical Care. 2014;18(6):711. https://doi.org/10.1186/s13054-014-0711-x
Aufderheide TP, Sigurdsson G, Pirrallo RG, Yannopoulos D, McKnite S, von Briesen C, Sparks CW, Conrad CJ, Provo TA, Lurie KG. Hyperventilation-induced hypotension during cardiopulmonary resuscitation. Circulation. 2004;109(16):1960-1965.
Davis DP, Hoyt DB, Ochs M, Fortlage D, Holbrook T, Marshall LK, Rosen P. The effect of paramedic rapid sequence intubation on outcome in patients with severe traumatic brain injury. The Journal of Trauma. 2003;54(3):444-453.
Curley G, Kavanagh BP, Laffey JG. Hypocapnia and the injured brain: more harm than benefit. Critical Care Medicine. 2010;38(5):1348-1359.
Stevens RD, Shoykhet M, Cadena R. Emergency neurological life support: intracranial hypertension and herniation. Neurocritcritical Care. 2015;23(suppl 2):76-82.
Quinn AC, Sinert R. What is the utility of the Focused Assessment with Sonography in Trauma (FAST) exam in penetrating torso trauma? Injury. 2011;42(5):482-487.
Fox JC, Boysen M, Gharahbaghian L, Cusick S, Ahmed SS, Anderson CL, Lekawa M, Langdorf MI. Test characteristics of focused assessment of sonography for trauma for clinically significant abdominal free fluid in pediatric blunt abdominal trauma. Academic Emergency Medicine. 2011;18(5):477-482. https://doi.org/10.1111/j.1553-2712.2011.01071.x
Linsenmaier U, Krotz M, Hauser H, Rock C, Rieger J, Bohndorf K, Pfeifer KJ, Reiser M. Wholebody computed tomography in polytrauma: techniques and management. European Radiology. 2002;12(7):1728-1740.
Wherrett LJ, Boulanger BR, McLellan BA, Brenneman FD, Rizoli SB, Culhane J, Hamilton P. Hypotension after blunt abdominal trauma: the role of emergent abdominal sonography in surgical triage. The Journal of Trauma. 1996;41(5):815-820.
Caputo N, Fraser R, Paliga A, Kanter M, Hosford K, Madlinger R. Triage vital signs do not correlate with serum lactate or base deficit, and are less predictive of operative intervention in penetrating trauma patients: a prospective cohort study. Emergency Medicine Journal. 2013;30(7):546-550.
Herbert HK, Dechert TA, Wolfe L, Aboutanos MB, Malhotra AK, Ivatury RR, Duane TM. Lactate in trauma: a poor predictor of mortality in the setting of alcohol ingestion. The American Surgeon. 2011;77(12):1576-1579.
Gustafson ML, Hollosi S, Chumbe JT, Samanta D, Modak A, Bethea A. The effect of ethanol on lactate and base deficit as predictors of morbidity and mortality in trauma. American Journal of Emergency Medicine. 2015;33(5):607-613.
Mutschler M, Nienaber U, Brockamp T, Wafaisade A, Fabian T, Paffrath T, Bouillon B, Maegele M; TraumaRegister DGU. Renaissance of base deficit for the initial assessment of trauma patients: a base deficit-based classification for hypovolemic shock developed on data from 16,305 patients derived from the TraumaRegister DGU(R). Critical Care. 2013;17(2):42. https://doi.org/10.1186/cc12555
Tauber H, Innerhofer P, Breitkopf R, Westermann I, Beer R, El Attal R, Strasak A, Mittermayr M. Prevalence and impact of abnormal ROTEM(R) assays in severe blunt trauma: results of the «Diagnosis and Treatment of Trauma-Induced Coagulopathy (DIA-TRE-TIC) study». British Journal of Anaesthesia. 2011;107(3):378-387. https://doi.org/10.1093/bja/aer15
Johansson PI, Stensballe J. Effect of haemostatic control resuscitation on mortality in massively bleeding patients: a before and after study. Vox Sanguinis. 2009;96(2):111-118.
Hussmann B, Lefering R, Waydhas C, Touma A, Kauther MD, Ruchholtz S, Lendemans S; Trauma Registry of the German Society for Trauma Surgery. Does increased prehospital replacement volume lead to a poor clinical course and an increased mortality? A matched-pair analysis of 1896 patients of the Trauma Registry of the German Society for Trauma Surgery who were managed by an emergency doctor at the accident site. Injury. 2013;44(5):611-617. https://doi.org/10.1016/j.injury.2012.02.004
Madigan MC, Kemp CD, Johnson JC, Cotton BA. Secondary abdominal compartment syndrome after severe extremity injury: are early, aggressive fluid resuscitation strategies to blame? The Journal of Trauma. 2008;64(2):280-285.
Haut ER, Kalish BT, Cotton BA, Efron DT, Haider AH, Stevens KA, Kieninger AN, Cornwell EE 3rd, Chang DC. Prehospital intravenous fluid administration is associated with higher mortality in trauma patients: a National Trauma Data Bank analysis. Annals of Surgery. 2011;253(2):371-377. https://doi.org/10.1097/SLA.0b013e318207c24f
Morrison CA, Carrick MM, Norman MA, Scott BG, Welsh FJ, Tsai P, Liscum KR, Wall MJ Jr, Mattox KL. Hypotensive resuscitation strategy reduces transfusion requirements and severe postoperative coagulopathy in trauma patients with hemorrhagic shock: preliminary results of a randomized controlled trial. The Journal of Trauma. 2011;70(3):652-663. https://doi.org/10.1097/TA.0b013e31820e77ea
Harrois A, Baudry N, Huet O, Kato H, Dupic L, Lohez M, Ziol M, Vicaut E, Duranteau J. Norepinephrine decreases fluid requirements and blood loss while preserving intestinal villi microcirculation during fluid resuscitation of uncontrolled hemorrhagic shock in mice. Anesthesiology. 2015;122(5):1093-1102. https://doi.org/10.1097/ALN.0000000000000639
Sperry JL, Minei JP, Frankel HL, West MA, Harbrecht BG, Moore EE, Maier RV, Nirula R. Early use of vasopressors after injury: caution before constriction. The Journal of Trauma. 2008;64(1):9-14. https://doi.org/10.1097/TA.0b013e31815dd029
Cohn SM, McCarthy J, Stewart RM, Jonas RB, Dent DL, Michalek JE. Impact of low-dose vasopressin on trauma outcome: prospective randomized study. World Journal of Surgery. 2011;35(2):430-439.
Chowdhury AH, Cox EF, Francis ST, Lobo DN. A randomized, controlled, double-blind crossover study on the effects of 2-L infusions of 0,9% saline and plasma-lyte(R) 148 on renal blood flow velocity and renal cortical tissue perfusion in healthy volunteers. Annals of Surgery. 2012;256(1):18-24.
Yunos NM, Bellomo R, Hegarty C, Story D, Ho L, Bailey M. Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults. JAMA. 2012;308(15):1566-1572.
Young JB, Utter GH, Schermer CR, Galante JM, Phan HH, Yang Y, Anderson BA, Scherer LA. Saline versus Plasma-Lyte A in initial resuscitation of trauma patients: a randomized trial. Annals of Surgery. 2014;259(2):255-262. https://doi.org/10.1097/SLA.0b013e318295feba
Perel P, Roberts I, Ker K. Colloids versus crystalloids for fluid resuscitation in critically ill patients. The Cochrane Database of Systematic Reviews. 2013;2:CD000567.
Kind SL, Spahn-Nett GH, Emmert MY, Eismon J, Seifert B, Spahn DR, Theusinger OM. Is dilutional coagulopathy induced by different colloids reversible by replacement of fibrinogen and factor XIII concentrates? Anesthesia and Analgesia. 2013;117(5):1063-1071. https://doi.org/10.1213/ANE.0b013e3182a52876
Wade CE, Grady JJ, Kramer GC. Efficacy of hypertonic saline dextran fluid resuscitation for patients with hypotension from penetrating trauma. The Journal of Trauma. 2003;54(5 suppl):144-148.
Holst LB, Haase N, Wetterslev J, Wernerman J, Guttormsen AB, Karlsson S, Johansson PI, Aneman A, Vang ML, Winding R, Nebrich L, Nibro HL, Rasmussen BS, Lauridsen JR, Nielsen JS, Oldner A, Pettilä V, Cronhjort MB, Andersen LH, Pedersen UG, Reiter N, Wiis J, White JO, Russell L, Thornberg KJ, Hjortrup PB, Müller RG, Møller MH, Steensen M, Tjäder I, Kilsand K, Odeberg-Wernerman S, Sjøbø B, Bundgaard H, Thyø MA, Lodahl D, Mærkedahl R, Albeck C, Illum D, Kruse M, Winkel P, Perner A; TRISS Trial Group; Scandinavian Critical Care Trials Group. Lower versus higher hemoglobin threshold for transfusion in septic shock. New England Journal of Medicine. 2014;371(15):1381-1391. https://doi.org/10.1056/NEJMoa1406617
Desjardins P, Turgeon AF, Tremblay MH, Lauzier F, Zarychanski R, Boutin A, Moore L, McIntyre LA, English SW, Rigamonti A, Lacroix J, Fergusson DA. Hemoglobin levels and transfusions in neurocritically ill patients: a systematic review of comparative studies. Critical Care. 2012;16(2):54. https://doi.org/10.1186/cc11293
Rubiano AM, Sanchez AI, Estebanez G, Peitzman A, Sperry J, Puyana JC. The effect of admission spontaneous hypothermia on patients with severe traumatic brain injury. Injury. 2013;44(9):1219-1225.
Shapiro MB, Jenkins DH, Schwab CW, Rotondo MF. Damage control: collective review. The Journal of Trauma. 2000;49(5):969-978.
Braslow B. Damage control in abdominal trauma. Contemporary Surgery. 2006;62:65-74.
Hsu JM, Pham TN. Damage control in the injured patient. International Journal of Critical Illness and Injury Science. 2011;1(1):66-72.
Caba-Doussoux P, Leon-Baltasar JL, Garcia-Fuentes C, Resines-Erasun C. Damage control orthopaedics in severe polytrauma with femur fracture. Injury. 2012;43(suppl 2):42-46.
Ertel W, Keel M, Eid K, Platz A, Trentz O. Control of severe hemorrhage using C-clamp and pelvic packing in multiply injured patients with pelvic ring disruption. Journal of Orthopaedic Trauma. 2001;15(7):468-474.
Brenner M, Hoehn M, Rasmussen TE. Endovascular therapy in trauma. European Journal of Trauma and Emergency Surgery. 2014;40(6):671-678.
Tanizaki S, Maeda S, Matano H, Sera M, Nagai H, Ishida H. Time to pelvic embolization for hemodynamically unstable pelvic fractures may affect the survival for delays up to 60 min. Injury. 2014;45(4):738-741.
Seyednejad H, Imani M, Jamieson T, Seifalian AM. Topical haemostatic agents. British Journal of Surgery. 2008;95(10):1197-1225.
Recinos G, Inaba K, Dubose J, Demetriades D, Rhee P. Local and systemic hemostatics in trauma: a review. Ulusal Travma ve Acil Cerrahi Dergisi. 2008;14(3):175-181.
Weber CF, Gorlinger K, Meininger D, Herrmann E, Bingold T, Moritz A, Cohn LH, Zacharowski K. Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients. Anesthesiology. 2012;117(3):531-547.
Nakayama Y, Nakajima Y, Tanaka KA, Sessler DI, Maeda S, Iida J, Ogawa S, Mizobe T. Thromboelastometry-guided intraoperative haemostatic management reduces bleeding and red cell transfusion after paediatric cardiac surgery. British Journal of Anaesthesia. 2015;114(1):91-102. https://doi.org/10.1093/bja/aeu339
Karkouti K, McCluskey SA, Callum J, Freedman J, Selby R, Timoumi T, Roy D, Rao V. Evaluation of a novel transfusion algorithm employing point-of-care coagulation assays in cardiac surgery: a retrospective cohort study with interrupted time-series analysis. Anesthesiology. 2015;122(3):560-570. https://doi.org/10.1097/ALN.0000000000000556
Cotton BA, Au BK, Nunez TC, Gunter OL, Robertson AM, Young PP. Predefined massive transfusion protocols are associated with a reduction in organ failure and postinjury complications. The Journal of Trauma. 2009;66(1):41-48. https://doi.org/10.1097/TA.0b013e31819313bb
Maciel JD, Gifford E, Plurad D, de Virgilio C, Bricker S, Bongard F, Neville A, Smith J, Putnam B, Kim D. The impact of a massive transfusion protocol on outcomes among patients with abdominal aortic injuries. Annals of Vascular Surgery. 2015;29(4):764-769.
Nascimento B, Callum J, Tien H, Rubenfeld G, Pinto R, Lin Y, Rizoli S. Effect of a fixed-ratio (1:1:1) transfusion protocol versus laboratory-results-guided transfusion in patients with severe trauma: a randomized feasibility trial. CMAJ: Canadian Medical Association Journal. 2013;185(12):583-589. https://doi.org/10.1503/cmaj.121986
Nardi G, Agostini V, Rondinelli B, Russo E, Bastianini B, Bini G, Bulgarelli S, Cingolani E, Donato A, Gambale G, Ranaldi G. Traumainduced coagulopathy: impact of the early coagulation support protocol on blood product consumption, mortality and costs. Critical Care. 2015;19(1):83. https://doi.org/10.1186/s13054-015-0817-9
Holcomb JB, Jenkins D, Rhee P, Johannigman J, Mahoney P, Mehta S, Cox ED, Gehrke MJ, Beilman GJ, Schreiber M, Flaherty SF, Grathwohl KW, Spinella PC, Perkins JG, Beekley AC, McMullin NR, Park MS, Gonzalez EA, Wade CE, Dubick MA, Schwab CW, Moore FA, Champion HR, Hoyt DB, Hess JR. Damage control resuscitation: directly addressing the early coagulopathy of trauma. The Journal of Trauma. 2007;62(2):307-310.
Ketchum L, Hess JR, Hiippala S. Indications for early fresh frozen plasma, cryoprecipitate, and platelet transfusion in trauma. The Journal of Trauma. 2006;60(6 suppl):51-58.
Holcomb JB, Hess JR. Early massive trauma transfusion: state of the art: editor’s introduction. Journal of Trauma and Acute Care Surgery. 2006;60(6):1-2.
Dente CJ, Shaz BH, Nicholas JM, Harris RS, Wyrzykowski AD, Patel S, Shah A, Vercruysse GA, Feliciano DV, Rozycki GS, Salomone JP, Ingram WL. Improvements in early mortality and coagulopathy are sustained better in patients with blunt trauma after institution of a massive transfusion protocol in a civilian level I trauma center. The Journal of Trauma. 2009;66(6):1616-1624. https://doi.org/10.1097/TA.0b013e3181a59ad5
Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O’Keeffe T, Rizoli S, Robinson BR, Scalea TM, Schreiber MA, Stein DM, Weinberg JA, Callum JL, Hess JR, Matijevic N, Miller CN, Pittet JF, Hoyt DB, Pearson GD, Leroux B, van Belle G; PROPPR Study Group. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA. 2015;313(5):471-482. https://doi.org/10.1001/jama.2015.12
Baraniuk S, Tilley BC, del Junco DJ, Fox EE, van Belle G, Wade CE, Podbielski JM, Beeler AM, Hess JR, Bulger EM, Schreiber MA, Inaba K, Fabian TC, Kerby JD, Cohen MJ, Miller CN, Rizoli S, Scalea TM, O’Keeffe T, Brasel KJ, Cotton BA, Muskat P, Holcomb JB; PROPPR Study Group. Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) Trial: design, rationale and implementation. Injury. 2014;45(9):1287-1295. https://doi.org/10.1016/j.injury.2014.06.001
Toy P, Popovsky MA, Abraham E, Ambruso DR, Holness LG, Kopko PM, McFarland JG, Nathens AB, Silliman CC, Stroncek D; National Heart, Lung and Blood Institute Working Group on TRALI. Transfusion-related acute lung injury: definition and review. Critical Care Medicine. 2005;33(4):721-726.
Holness L, Knippen MA, Simmons L, Lachenbruch PA. Fatalities caused by TRALI. Transfusion Medicine Reviews. 2004;18(3):184-188.
CRASH-2 Trial Collaborators, Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, Hunt B, Iribhogbe P, Izurieta M, Khamis H, Komolafe E, Marrero MA, Mejía-Mantilla J, Miranda J, Morales C, Olaomi O, Olldashi F, Perel P, Peto R, Ramana PV, Ravi RR, Yutthakasemsunt S. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo controlled trial. Lancet. 2010;376:23-32. https://doi.org/10.1016/S0140-6736(10)60835-5
Roberts I, Shakur H, Ker K, Coats T; CRASH-2 Trial collaborators. Antifibrinolytic drugs for acute traumatic injury. The Cochrane Database of Systematic Reviews. 2012;12:CD004896. https://doi.org/10.1002/14651858
Roberts I, Prieto-Merino D, Manno D. Mechanism of action of tranexamic acid in bleeding trauma patients: an exploratory analysis of data from the CRASH-2 trial. Critical Care. 2014;18(6):685.
CRASH-2 collaborators, Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt BJ, Morales C, Perel P, Prieto-Merino D, Woolley T. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet. 2011;377(9771):1096-1101. https://doi.org/10.1016/S0140-6736(11)60278-X
Roberts I, Perel P, Prieto-Merino D, Shakur H, Coats T, Hunt BJ, Lecky F, Brohi K, Willett K; CRASH-2 Collaborators. Effect of tranexamic acid on mortality in patients with traumatic bleeding: prespecified analysis of data from randomised controlled trial. BMJ. 2012;345:e5839. https://doi.org/10.1136/bmj.e5839
Kozek-Langenecker SA, Ahmed AB., Afshari A, Albaladejo P, Aldecoa C, Barauskas G, De Robertis E, Faraoni D, Filipescu DC, Fries D, Haas T, Jacob M, Lancé MD, Pitarch JVL, Mallett S, Meier J, Molnar ZL, Rahe-Meyer N, Samama CM, Stensballe J, Van der Linden PJF, Wikkelsø AJ, Wouters P, Wyffels P, Zacharowski K. Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology. European Journal of Anesthesiology. 2017;34:332-395. https://doi.org/10.1097/EJA.0000000000000630
Rossaint R, Bouillon B, Cerny V, Coats TJ, Duranteau J, Fernández-Mondéjar E, Filipescu D, Hunt BJ, Komadina R, Nardi G, Neugebauer EA, Ozier Y, Riddez L, Schultz A, Vincent JL, Spahn DR. The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Critical Care. 2016;20:100. https://doi.org/10.1186/s13054-016-1265-x
Practice guidelines for perioperative blood management. An updated report by the American Society of Anesthesiologists. Task force on perioperative blood management. Anesthesiology. 2015;122(5):241-275. https://doi.org/10.1097/ALN.0000000000000463
Gayet-Ageron A, Prieto-Merino D, Ker K, Shakur H, Ageron FX, Roberts I; Antifibrinolytic Trials Collaboration. Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients. Lancet. 2018;391(10116):125-132. https://doi.org/10.1016/S0140-6736(17)32455-8
Hiippala ST, Myllyla GJ, Vahtera EM. Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates. Anesthesia and Analgesia. 1995;81(2):360-365.
Schöchl H, Cotton B, Inaba K, Nienaber U, Fischer H, Voelckel W, Solomon C. FIBTEM provides early prediction of massive transfusion in trauma. Critical Care. 2011;15(6):R265. https://doi.org/10.1186/cc10539
Stinger HK, Spinella PC, Perkins JG, Grathwohl KW, Salinas J, Martini WZ, Hess JR, Dubick MA, Simon CD, Beekley AC, Wolf SE, Wade CE, Holcomb JB. The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital. The Journal of Trauma. 2008;64(2 suppl):79-85. https://doi.org/10.1097/TA.0b013e318160a57
Schöchl H, Nienaber U, Maegele M, Hochleitner G, Primavesi F, Steitz B, Arndt C, Hanke A, Voelckel W, Solomon C. Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy. Critical Care. 2011;15(2):83. https://doi.org/10.1186/cc10078
Schöchl H, Nienaber U, Hofer G, Voelckel W, Jambor C, Scharbert G, Kozek-Langenecker S, Solomon C. Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEMW)-guided administration of fibrinogen concentrate and prothrombin complex concentrate. Critical Care. 2010;14:55. https://doi.org/10.1186/cc8948
Shaz BH, Dente CJ, Nicholas J, MacLeod JB, Young AN, Easley K, Ling Q, Harris RS, Hillyer CD. Increased number of coagulation products in relationship to red blood cell products transfused improves mortality in trauma patients. Transfusion. 2010;50(2):493-500. https://doi.org/10.1111/j.1537-2995.2009.02414.x
Counts RB, Haisch C, Simon TL, Maxwell NG, Heimbach DM, Carrico CJ. Hemostasis in massively transfused trauma patients. Annals of Surgery. 1979;190(1):91-99.
Ciavarella D, Reed RL, Counts RB, Baron L, Pavlin E, Heimbach DM, Carrico CJ. Clotting factor levels and the risk of diffuse microvascular bleeding in the massively transfused patient. British Journal of Haematology. 1987;67(3):365-368.
Stansbury LG, Hess AS, Thompson K, Kramer B, Scalea TM, Hess JR. The clinical significance of platelet counts in the first 24 hours after severe injury. Transfusion. 2013;53(4):783-789. https://doi.org/10.1111/j.1537-2995.2012.03828.x
Johansson PI, Stensballe J, Rosenberg I, Hilsløv TL, Jørgensen L, Secher NH. Proactive administration of platelets and plasma for patients with a ruptured abdominal aortic aneurysm: evaluating a change in transfusion practice. Transfusion. 2007;47(4):593-598.
Joseph B, Aziz H, Zangbar B, Kulvatunyou N, Pandit V, O’Keeffe T, Tang A, Wynne J, Friese RS, Rhee P. Acquired coagulopathy of traumatic brain injury defined by routine laboratory tests: which laboratory values matter? Journal of Trauma and Acute Care Surgery. 2014;76(1):121-125. https://doi.org/10.1097/TA.0b013e3182a9cc95
Kashuk JL, Moore EE, Johnson JL, Haenel J, Wilson M, Moore JB, Cothren CC, Biffl WL, Banerjee A, Sauaia A. Postinjury life threatening coagulopathy: is 1:1 fresh frozen plasma: packed red blood cells the answer? The Journal of Trauma. 2008;65(2):261-270. https://doi.org/10.1097/TA.0b013e31817de3e1
Nekludov M, Bellander BM, Blomback M, Wallen HN. Platelet dysfunction in patients with severe traumatic brain injury. Journal of Neurotrauma. 2007;24(11):1699-1706.
Wohlauer MV, Moore EE, Thomas S, Sauaia A, Evans E, Harr J, Silliman CC, Ploplis V, Castellino FJ, Walsh M. Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma. Journal of the American College of Surgeons. 2012;214(5):739-746. https://doi.org/10.1016/j.jamcollsurg.2012.01.050
Holcomb JB, Wade CE, Michalek JE, Chisholm GB, Zarzabal LA, Schreiber MA, Gonzalez EA, Pomper GJ, Perkins JG, Spinella PC, Williams KL, Park MS. Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Annals of Surgery. 2008;248(3):447-458. https://doi.org/10.1097/SLA.0b013e318185a9ad
Zink KA, Sambasivan CN, Holcomb JB, Chisholm G, Schreiber MA. A high ratio of plasma and platelets to packed red blood cells in the first 6 hours of massive transfusion improves outcomes in a large multicenter study. American Journal of Surgery. 2009;197(5):565-570. discussion 570. https://doi.org/10.1016/j.amjsurg.2008.12.014
McQuilten ZK, Crighton G, Engelbrecht, Gotmaker R, Brunskill SJ, Murphy MF, Wood EM. Transfusion interventions in critical bleeding requiring massive transfusion: a systematic review. Transfusion Medicine Reviews. 2015;29(2):127-137. https://doi.org/10.1016/j.tmrv.2015.01.001
Ho KM, Leonard AD. Concentration-dependent effect of hypocalcaemia on mortality of patients with critical bleeding requiring massive transfusion: a cohort study. Anaesthesia and Intensive Care. 2011;39(1):46-54.
Perkins JG, Cap AP, Weiss BM, Reid TJ, Bolan CD. Massive transfusion and nonsurgical hemostatic agents. Critical Care Medicine. 2008;36(7 suppl):325-339. https://doi.org/10.1097/CCM.0b013e31817e2ec5
Quinlan DJ, Eikelboom JW, Weitz JI. Four-factor prothrombin complex concentrate for urgent reversal of vitamin K antagonists in patients with major bleeding. Circulation. 2013;128(11):1179-1181. https://doi.org/10.1161/CIRCULATIONAHA.113.005107
Sarode R, Milling Jr TJ, Refaai MA, Mangione A, Schneider A, Durn BL, Goldstein JN. Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study. Circulation. 2013;128(11):1234-1243. https://doi.org/10.1161/CIRCULATIONAHA.113.002283
Goldstein JN, Refaai MA, Milling Jr TJ, Lewis B, Goldberg-Alberts R, Hug BA, Sarode R. Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial. Lancet. 2015;385(9982):2077-2087. https://doi.org/10.1016/S0140-6736(14)61685-8
Huttner HB, Schellinger PD, Hartmann M, Köhrmann M, Juettler E, Wikner J, Mueller S, Meyding-Lamade U, Strobl R, Mansmann U, Schwab S, Steiner T. Hematoma growth and outcome in treated neurocritical care patients with intracerebral hemorrhage related to oral anticoagulant therapy: comparison of acute treatment strategies using vitamin K, fresh frozen plasma, and prothrombin complex concentrates. Stroke. 2006;37(6):1465-1470.
Edavettal M, Rogers A, Rogers F, Horst M, Leng W. Prothrombin complex concentrate accelerates international normalized ratio reversal and diminishes the extension of intracranial hemorrhage in geriatric trauma patients. The American Surgeon. 2014;80(4):372-376.
Baglin TP, Keeling DM, Watson HG. Guidelines on oral anticoagulation (warfarin): third edition-2005 update. British Journal of Haematology. 2006;132(3):277-285.
Knudson MM, Cohen MJ, Reidy R, Jaeger S, Bacchetti P, Jin C, Wade CE, Holcomb JB. Trauma, transfusions, and use of recombinant factor VIIa: a multicenter case registry report of 380 patients from the Western Trauma Association. Journal of the American College of Surgeons. 2011;212(1):87-95. https://doi.org/10.1016/j.jamcollsurg.2010.08.020
Mitra B, Cameron PA, Parr MJ, Phillips L. Recombinant factor VIIa in trauma patients with the «triad of death». Injury. 2012;43(9):1409-1414.
Hauser CJ, Boffard K, Dutton R, Bernard GR, Croce MA, Holcomb JB, Leppaniemi A, Parr M, Vincent JL, Tortella BJ, Dimsits J, Bouillon B; CONTROL Study Group. Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. The Journal of Trauma. 2010;69(3):489-500. https://doi.org/10.1097/TA.0b013e3181edf36e
Shen X, Dutcher SK, Palmer J, Liu X, Kiptanui Z, Khokhar B, Al-Jawadi MH, Zhu Y, Zuckerman IH. A systematic review of the benefits and risks of anticoagulation following traumatic brain injury. Journal of Head Trauma Rehabilitation. 2015;30(4):29-37.
Alhazzani W, Lim W, Jaeschke RZ, Murad MH, Cade J, Cook DJ. Heparin thromboprophylaxis in medical-surgical critically ill patients: a systematic review and meta-analysis of randomized trials. Critical Care Medicine. 2013;41(9):2088-2098. https://doi.org/10.1097/CCM.0b013e31828cf104
Lim W, Meade M, Lauzier F, Zarychanski R, Mehta S, Lamontagne F, Dodek P, McIntyre L, Hall R, Heels-Ansdell D, Fowler R, Pai M, Guyatt G, Crowther MA, Warkentin TE, Devereaux PJ, Walter SD, Muscedere J, Herridge M, Turgeon AF, Geerts W, Finfer S, Jacka M, Berwanger O, Ostermann M, Qushmaq I, Friedrich JO, Cook DJ; PROphylaxis for ThromboEmbolism in Critical Care Trial Investigators. Failure of anticoagulant thromboprophylaxis: risk factors in medical-surgical critically ill patients. Critical Care Medicine. 2015;43(2):401-410. https://doi.org/10.1097/CCM.0000000000000713
Shifman EM, Kulikov AV, Ronenson AM, Abazova IS, Adamyan LV, Andreeva MD, Artymuk NV, Baev OR, Barinov SV, Belokrinitskaya TE, Blauman SI, Bratishchev IV, Bukhtin AA, Vartanov VY, Volkov AB, Gorokhovskiy VS, Dolgushina NV, Drobinskaya AN, Kinzhalova SV, KitiashviliIZ, Kogan IYu, Korolev AYu, Krasnopolskii VI, Kukarskaya II, Kurcer MA, Marshalov DV, Matkovskiy AA, Ovezov AM, Penzhoyan GA, Pestrikova TYu, Petruhin VA, Prihodko AM, Protopopova NV, Protsenko DN, Pyregov AV, Raspopin YuS, Rogachevskiy OV, Ryazanova OV, Savelyeva GM, SemenovYuA, Sitkin SI, Fatkullin IF, Fedorova TA, Filippov OS,Shvechkova MV, Shmakov RG, Shchegolev AV, Zabolotskikh IB. Prevention, the algorithm of reference, anesthesia an intensive care for postpartum hemorrhage. Guidelines. Vestnik intensivnoj terapii im. A.I. Saltanova. 2019;3:9-33. (In Russ.) https://doi.org/10.21320/1818-474X-2019-3-9-33

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