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Chernov I.V.

Burdenko Neurosurgical Center

Shkarubo A.N.

Burdenko Neurosurgical Center

Konyashin D.A.

Burdenko Voronezh State Medical University

Andreev D.N.

Burdenko Neurosurgical Center

Transoral approach in surgery for chordomas extending into craniovertebral junction: a systematic review of the literature

Authors:

Chernov I.V., Shkarubo A.N., Konyashin D.A., Andreev D.N.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2024;88(3): 111‑119

DOI: 10.17116/neiro202488031111

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Table of contents

TRANSORAL APPROACH IN SURGERY FOR CHORDOMAS EXTENDING INTO CRANIOVERTEBRAL JUNCTION: A SYSTEMATIC REVIEW OF THE LITERATURE
TRANSORAL APPROACH IN SURGERY FOR CHORDOMAS EXTENDING INTO CRANIOVERTEBRAL JUNCTION: A SYSTEMATIC REVIEW OF THE LITERATURE

To cite this article:

Chernov IV, Shkarubo AN, Konyashin DA, Andreev DN. Transoral approach in surgery for chordomas extending into craniovertebral junction: a systematic review of the literature. Burdenko's Journal of Neurosurgery. 2024;88(3):111‑119. (In Russ., In Engl.)
https://doi.org/10.17116/neiro202488031111

Подписка 2025-2 (Burdenko's Journal of Neurosurgery)
 
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To date, treatment of chordomas involves maximal tumor resection followed by proton therapy. Various approaches are used depending on location of tumor (transcranial and through natural anatomical openings (nose, mouth), as well as their combinations). Although transoral approach has been introduced into neurosurgical practice for a long time, it is routinely used in patients with chordoma only in certain hospitals in the world.

OBJECTIVE

To analyze postoperative outcomes in patients with chordomas of skull base and craniovertebral joint after transoral surgery.

MATERIAL AND METHODS

We analyzed literature data devoted to patients with chordomas of skull base and craniovertebral joint after transoral surgery or another approach combined with transoral access. Among 111 primary articles, we selected 38 manuscripts including description of 109 patients with skull base chordoma who underwent transoral surgery or combination of approaches including transoral one.

RESULTS

Gross total resection was achieved in 45.9% (n=50) of cases including 1 patient after en bloc resection. Subtotal resection was carried out in 28.4% of cases, partial — in 24.8%, biopsy — in 0.9% of cases. The complication rate in this group was 30%. The most common events were swelling of the tongue (10%) and diastasis of posterior pharyngeal wall sutures (8.2%) that required redo surgery. CSF leakage and meningitis were rare (1.8% and 3.6%, respectively).

CONCLUSION

Transoral access allows for gross total resection of midline tumors with low incidence of severe complications. Combination of transoral and transcranial approaches is advisable to increase extent of resection.

Keywords:

chordoma
transoral approach

Authors:

Chernov I.V.

Burdenko Neurosurgical Center

Shkarubo A.N.

Burdenko Neurosurgical Center

Konyashin D.A.

Burdenko Voronezh State Medical University

Andreev D.N.

Burdenko Neurosurgical Center

Received:

14.12.2023

Accepted:

22.03.2024

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