Treatment of malignant peripheral nerve sheath tumors: case reports and a literature review

Konovalov N.A.; Korolishin V.A.; Asiutin D.S.; Timonin S.Iu.; Shults M.A.; Solenkova A.V.; Zakirov B.A.; Batyrov A.A.

doi:https://doi.org/10.17116/neiro20198303164

Konovalov N.A.

OOO Klinika spinal'noĭ neĭrokhirurgii «Aksis»;
NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

ORCID: 0000-0003-0824-1848

Korolishin V.A.

OOO Klinika spinal'noĭ neĭrokhirurgii «Aksis»;
NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Asiutin D.S.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

Timonin S.Iu.

Pervyĭ MGMU im. I.M. Sechenova, Moskva

Shults M.A.

Burdenko Neurosurgical Center, Moscow, Russia

Solenkova A.V.

Burdenko Neurosurgical Institute, Moscow, Russia

Zakirov B.A.

FGBNU "NII neĭrokhirurgii im. akad. N.N. Burdenko", RAMN, Moskva

Batyrov A.A.

Burdenko Neurosurgical Institute, Moscow, Russia

Treatment of malignant peripheral nerve sheath tumors: case reports and a literature review

Authors:

Konovalov N.A., Korolishin V.A., Asiutin D.S., Timonin S.Iu., Shults M.A., Solenkova A.V., Zakirov B.A., Batyrov A.A.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2019;83(3): 64‑72

DOI: 10.17116/neiro20198303164

Read: 12028 times

To cite this article:

Konovalov NA, Korolishin VA, Asiutin DS, et al. . Treatment of malignant peripheral nerve sheath tumors: case reports and a literature review. Burdenko's Journal of Neurosurgery. 2019;83(3):64‑72. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20198303164

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)

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Abstract:

Malignant peripheral nerve sheath tumors (MPNSTs) are soft tissue sarcomas that develop from peripheral nerve sheath cells (T. Hirose, B.W. Scheithauer). These tumors are characterized by aggressive growth with an unfavorable outcome and may develop de novo or through malignant transformation of schwannomas, neurofibromas, or ganglioneuromas. MPNSTs are characterized by a rapid course and a poor prognosis. In this article, we reported cases of patients with malignant peripheral nerve tumors of the brachial plexus trunks and spinal localization.

Keywords:

malignant neurofibroma

neurogenic sarcoma

malignant peripheral nerve sheath tumor

Authors:

Konovalov N.A.

OOO Klinika spinal'noĭ neĭrokhirurgii «Aksis»;
NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

ORCID: 0000-0003-0824-1848

Korolishin V.A.

OOO Klinika spinal'noĭ neĭrokhirurgii «Aksis»;
NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Asiutin D.S.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

Timonin S.Iu.

Pervyĭ MGMU im. I.M. Sechenova, Moskva

Shults M.A.

Burdenko Neurosurgical Center, Moscow, Russia

Solenkova A.V.

Burdenko Neurosurgical Institute, Moscow, Russia

Zakirov B.A.

FGBNU "NII neĭrokhirurgii im. akad. N.N. Burdenko", RAMN, Moskva

Batyrov A.A.

Burdenko Neurosurgical Institute, Moscow, Russia

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References:

Hruban RH, Shiu MH, Senie R, Woodruff JM: malignant tumors of peripheral nerve sheath buttock and lower extremity a study of 43 cases. Cancer. 1990;66:1253-1265. doi: 10.1002/1097;2-p
Bailet JW, Abemayor E, Andrews JC, Rowland JP, Fu YS, Dawson DE. Malignant nerve sheath tumors of the head and neck: a combined experience from two university hospitals. Laryngoscope. 1991;101:1044-1049.
Angelova L, O’sullivan B, Bell R, Guha A. Neurogenic sarcoma: experience at the University of Toronto. Neurosurgery. 1998;43(1):56-64.
Angelov L, Guha A. Peripheral Nerve Tumors. Neuro Oncology Foundation. Edited by: Bernstein m, Ms. Berger. 2000, N.Y. Theme Publishers.
Chibbaro S, Herman P, Povlika M, George B. Malignant trigeminal schwannoma extending into the anterior skull base. Acta Neurochir (Wien). 2008;150(6):599-604.
Stone JA, Cooper H, Castillo M, Mukherji SK. Malignant schwannoma of the trigeminal nerve. Am J Neuroradiol. 2001;22:505-507.
Karmody CS. Malignant schwannoma of the trigeminal nerve. Otolaringol Head Neck Surg. 1979;87:594-598.
Brenner W, Gawad KA, Hagel C, von Deimling A, de Wit M, Boucher R, Clausen M, Mautner F. Prognostic value of PET FDG in patients with neurofibromatosis 1-type and malignant tumors of peripheral nerve sheath. Eur J Nucl Med Mol Imaging. 2006;11:1-5.
Evans D, McGaughran J, Sharif S, Howard E. Moran is: malignant tumor of peripheral nerve sheath in neurofibromatosis 1. J Jeunet Honey. 2002;39(5):311-314.
D’agostino SE, Miller OB. Sarcoma of the peripheral nerves and somatic soft tissues associated with multiple neurofibromatosis (Recklinghausen’s disease von’s). Cancer. 1963;16:1015-1027.
Friedrich KL, Funster, Mautner F. malignant tumors of peripheral nerve sheath (MPNST) in neurofibromatosis Type 1 (NF1): diagnostic results on the magnetic resonance image and analysis of mutation of NF1 Gene. 25, (3A). (May-June): 2005;1699-1702.
Ferner RE, George L, O’doherty MJ, Hughes RAC, Smith MA, Cronin BF, Bingham JB. Evaluation of 18 fluorodeoxyglucose positron emission tomography in the detection of malignant tumors of the peripheral nerve sheath in neurofibromatosis 1. J Evaluation Neurosurg Psychiatry. 2000;68:353-357.
Ferner RE, Gutman DH. International consensus statement on malignant tumors of the peripheral nerve sheath in neurofibromatosis. Cancer research. 2002;62(5):1573-1577.
Werner RE, Gutmann DH. International consensus statement on malignant tumors of the peripheral nerve sheath in neurofibromatosis. Cancer Res. 2002;62:1573-1577.
Ramanathan Thomas DM. A malignant tumor of the shell of peripheral nerves associated with neurofibromatosis von Hausen in the Museum district. The radio-controlled. Eur J Surg Oncol. 1999;25:190-193. doi: 10.1053 / ejso.1998.0625
Amin SA, Flanagan A, Patterson D, Lehovsky J. Radiation therapy — induced malignant tumors of the peripheral nerves of the caudal tail. Spine. 2004;29(21):E506-E509.
Ducatiman SAT, Bernd, David GP. Herbert, Dwayne MI: malignant tumors of the peripheral nerve sheath. Clinical and morphological study of 120 cases. Cancer. 1986;57:2006-2021;2-6.
Hornick JL, Bundock EA, Fletcher CD. Hybrid schwannoma/perineurioma: Clinicopathologic analysis of 42 distinctive benign nerve sheath tumors. Am J Surg Pathol. 2009;33:1554-1561.
Heslin ML, Lewis JJ, Woodruff JM, Brennan MF. Ki-67 detected by MIB-1 predicts distant metastasis and tumor mortality in primary, high grade extremity sarcoma of soft tissues. Cancer. 1998;83(3):490-497.
Hirose T, Scheithauer BW, Sano T. Perineural malignant tumor of peripheral nerve sheath (MPNST) is a clinical, morphological, immunohistochemical and ultrastructural study of seven cases. J Surg Journal of Pathology. 1998;22:1368-1378. doi: 10.1097/00000478-199811000-00007
Carly MFA, Mattke A, Zanetti I, Casanova M, Need G, Cecchetto G, Alaggio R, de SIO L, Koscielniak E, Sotti G, Treuner J. Pediatric malignant tumor peripheral nerve sheath: Italian and German soft tissue sarcoma cooperative group. John Kohl Klin. 2005;23(33):8422-8430.
Nambisan RN, Rao U, Moore R, Karakousis CP. Malignant soft tissue tumors of nerve sheath origin. J Surg Oncol. 1984;25:268-272.
Action DV, Ruskin TO, Hornicek J, Gebhardt MC, Mankin HJ. Survival data for patients with malignant schwannoma. Wedge Orthop Relat Res. 2004;426:69-73.
Masaru F, Descended from Beppu G, Asanuma TO, Fuji K. A malignant tumor of the peripheral nerve sheath responds to chemotherapy. J Bone Joint Surgery Br. 2004;86(1):6113-6115.
Weiss IT, Goldblum Jr. Soft tissue tumors. St. Louis Mosby Co. 2001;1209-1263.
Scheithauer BW, Woodruff WM, Erlandsson RA. Tumors of the peripheral nervous system. Atlas of tumor pathology. 1999;3rd series(24).
Ducatman BS, Scheithauer BW. Malignant peripheral nerve sheath tumors with divergent differentiation. Cancer. 1984;54:1049-1057.
Stucky CC, Johnson KN, Gray RJ, Pockaj BA, Ocal IT, Rose PS, Wasif N. Malignant peripheral nerve sheath tumors (MPNST): the Mayo Clinic experience. Annals of surgical oncology. 2012;19(3):878-885.
Shimizu K, Okita R, Uchida Y, Hihara J. Long survival after resection for lung metastasis of malignant peripheral nerve sheath tumor in neurofibromatosis 1. Ann Thorac Cardiovasc Surg. 2008;14(5):322-324.
Kroep JR, Ouali M, Gelderblom H, Le Cesne A, Dekker TJ, Van Glabbeke M, Hogendoorn PC, Hohenberger P. First-line chemotherapy for malignant peripheral nerve sheath tumor (MPNST) versus other histological soft tissue sarcoma subtypes and as a prognostic factor for MPNST: an EORTC soft tissue and bone sarcoma group study. Annals of oncology. 2010;22(1):207-214.