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Lapshina A.M.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Marova E.I.

Endocrinology Research Centrer

Evaluation of the biological behavior of ACTH-secreting pituitary tumors using various methods

Authors:

Lapshina A.M., Marova E.I.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2015;79(6): 107‑114

DOI: 10.17116/neiro2015796107-114

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EVALUATION OF THE BIOLOGICAL BEHAVIOR OF ACTH-SECRETING PITUITARY TUMORS USING VARIOUS METHODS
EVALUATION OF THE BIOLOGICAL BEHAVIOR OF ACTH-SECRETING PITUITARY TUMORS USING VARIOUS METHODS

To cite this article:

Lapshina AM, Marova EI. Evaluation of the biological behavior of ACTH-secreting pituitary tumors using various methods. Burdenko's Journal of Neurosurgery. 2015;79(6):107‑114. (In Russ., In Engl.)
https://doi.org/10.17116/neiro2015796107-114

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
 
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Abstract:

This literature review is aimed at studying markers obtained by various research methods to assess the biological behavior of ACTH-secreting pituitary tumors. This paper presents the clinical, laboratory, instrumental, histological, and immunohistochemical aspects of ACTH-secreting pituitary tumors. Histological method allows assessing the structures of a tumor and differential diagnosis of other pathological processes in the sella turcica. Immunohistochemical method enables determining the expression of multiple markers (fibroblast growth factors, matrix metalloproteinases, apoptotic factors, pituitary tumor transforming gene, and vascular markers), which reflect various processes of oncogenesis of studied tumors, and, according to the authors, are promising with regard to predicting biological behavior using corticotropin. Epigenetic investigations including the study of micro-RNA expression, proteomics, and transcriptomics are the new methods in this area, which are expected to provide additional details regarding the prediction using corticotropin. Thus, the cumulative assessment using laboratory and instrumental methods, the study of immunoexpression of malignant potential markers in the tissue using corticotropin and micro-RNA allow predicting the future biological behavior of ACTH-secreting pituitary tumors.

Keywords:

ACTH-secreting pituitary tumor
evaluation and markers of malignant potential

Authors:

Lapshina A.M.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva

Marova E.I.

Endocrinology Research Centrer

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