A correlation between diffusion kurtosis imaging and the proliferative activity of brain glioma

Tonoyan A.S.; Pronin I.N.; Pitskhelauri D.I.; Shishkina L.V.; Fadeeva L.M.; Pogosbekyan E.L.; Zakharova N.E.; Shul'ts E.I.; Khachanova N.V.; Kornienko V.N.; Potapov A.A.

doi:https://doi.org/10.17116/neiro20157965-14

Tonoyan A.S.

Burdenko Neurosurgical Institute, Moscow, Russia

Pronin I.N.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Pitskhelauri D.I.

Burdenko Neurosurgical Center

SPIN RSCI: 3261-2144
Scopus AuthorID: 6507820245
ORCID: 0000-0003-0374-7970

Shishkina L.V.

Burdenko Neurosurgery Institute, Moscow, Russia

ORCID: 0000-0001-7045-7223

Fadeeva L.M.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Pogosbekyan E.L.

Burdenko Neurosurgical Institute, Moscow, Russia

Zakharova N.E.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Shul'ts E.I.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

SPIN RSCI: 3255-8587
Scopus AuthorID: 57112078200
ORCID: 0000-0001-5406-944X

Khachanova N.V.

Burdenko Neurosurgical Institute, Moscow, Russia

Kornienko V.N.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Potapov A.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

A correlation between diffusion kurtosis imaging and the proliferative activity of brain glioma

Authors:

Tonoyan A.S., Pronin I.N., Pitskhelauri D.I., Shishkina L.V., Fadeeva L.M., Pogosbekyan E.L., Zakharova N.E., Shul'ts E.I., Khachanova N.V., Kornienko V.N., Potapov A.A.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2015;79(6): 5‑14

DOI: 10.17116/neiro20157965-14

Read: 2188 times

To cite this article:

Tonoyan AS, Pronin IN, Pitskhelauri DI, et al. . A correlation between diffusion kurtosis imaging and the proliferative activity of brain glioma. Burdenko's Journal of Neurosurgery. 2015;79(6):5‑14. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20157965-14

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)

Использование инфографики авторами научных работ

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Abstract:

The aim of the study was to assess the capabilities of diffusion kurtosis imaging (DKI) in diagnosis of the glioma proliferative activity and to evaluate a relationship between the glioma proliferative activity index and diffusion parameters of the contralateral normal appearing white matter (CNAWM). Material and methods. The study included 47 patients with newly diagnosed brain gliomas (23 low grade, 13 grade III, and 11 grade IV gliomas). We determined a relationship between absolute and normalized parameters of the diffusion tensor (mean (MD), axial (AD), and radial (RD) diffusivities; fractional (FA) and relative (RA) anisotropies) and diffusion kurtosis (mean (MK), axial (AK), and radial (RK) kurtosis; kurtosis anisotropy (KA)) and the proliferative activity index in the most malignant glioma parts (p<0.05). We also established a relationship between the tensor and kurtosis parameters of CNAWM and the glioma proliferative activity index (p<0.05). Results. The correlation between all the absolute and normalized diffusion parameters and the glioma proliferative activity index, except absolute and normalized FA and RA values, was found to be statistically significant (p<0.05). Kurtosis (MK, AK, and RK) and anisotropy (KA, FA, RA) values increased, and diffusivity (MD, AD, RD) values decreased as the glioma proliferative activity index increased. A strong correlation between the proliferative activity index and absolute RK (r=0,71; p=0.000001) and normalized values of MK (r=0.8; p=0.000001), AK (r=0.71; p=0.000001), RK (r=0.81; p=0.000001), and RD (r=−0.71; p=0.000001) was found. A weak, but statistically significant correlation between the glioma proliferative activity index and diffusion values RK (r=−0.36; p=0.014), KA (r=−0.39; p=0.007), RD (r=0.35; p=0.017), FA (r=−0.42; p=0.003), and RA (r=−0.41; p=0.004) of CNAWM was found. Conclusion. DKI has good capabilities to detect immunohistochemical changes in gliomas. DKI demonstrated a high sensitivity in detection of microstructural changes in the contralateral normal appearing white matter in patients with brain gliomas.

Keywords:

diffusion tensor

diffusion kurtosis

glioma

malignant

proliferative activity

Authors:

Tonoyan A.S.

Burdenko Neurosurgical Institute, Moscow, Russia

Pronin I.N.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Pitskhelauri D.I.

Burdenko Neurosurgical Center

SPIN RSCI: 3261-2144
Scopus AuthorID: 6507820245
ORCID: 0000-0003-0374-7970

Shishkina L.V.

Burdenko Neurosurgery Institute, Moscow, Russia

ORCID: 0000-0001-7045-7223

Fadeeva L.M.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Pogosbekyan E.L.

Burdenko Neurosurgical Institute, Moscow, Russia

Zakharova N.E.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Shul'ts E.I.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

SPIN RSCI: 3255-8587
Scopus AuthorID: 57112078200
ORCID: 0000-0001-5406-944X

Khachanova N.V.

Burdenko Neurosurgical Institute, Moscow, Russia

Kornienko V.N.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Potapov A.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Close metadata

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