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Ryzhova M.V.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

Shishkina L.V.

Burdenko Neurosurgery Institute, Moscow, Russia

Zheludkova O.G.

GU FNKTs detskoĭ gematologii, onkologii i immunologii Minzdrava RF im. D. Rogacheva, Moskva

Golanov A.V.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

Gorelyshev S.K.

GBU NII neĭrokhirurgii im. N.N. Burdenko

Pitskhelauri D.I.

Burdenko Neurosurgical Center

Bekiashev A.Kh.

FGBU "Rossiĭskiĭ nauchnyĭ onkologicheskiĭ tsentr im. N.N. Blokhina" RAMN, Moskva, Rossiia

Kobiakov G.L.

GBU NII neĭrokhirurgii im. N.N. Burdenko

Absaliamova O.V.

FGBU "Nauchno-issledovatel'skiĭ institut neĭrokhirurgii im. akad. N.N. Burdenko"

Sycheva R.V.

FGBU "Nauchno-issledovatel'skiĭ institut neĭrokhirurgii im. akad. N.N. Burdenko"

Korshunov A.G.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

Сomparative characteristics of genetic aberrations in glioblastomas in children and adults

Authors:

Ryzhova M.V., Shishkina L.V., Zheludkova O.G., Golanov A.V., Gorelyshev S.K., Pitskhelauri D.I., Bekiashev A.Kh., Kobiakov G.L., Absaliamova O.V., Sycheva R.V., Korshunov A.G.

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Journal: Burdenko's Journal of Neurosurgery. 2014;78(2): 3‑11

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Table of contents

СOMPARATIVE CHARACTERISTICS OF GENETIC ABERRATIONS IN GLIOBLASTOMAS IN CHILDREN AND ADULTS
СOMPARATIVE CHARACTERISTICS OF GENETIC ABERRATIONS IN GLIOBLASTOMAS IN CHILDREN AND ADULTS

To cite this article:

Ryzhova MV, Shishkina LV, Zheludkova OG, et al. Сomparative characteristics of genetic aberrations in glioblastomas in children and adults. Burdenko's Journal of Neurosurgery. 2014;78(2):3‑11. (In Russ., In Engl.)

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Glioblastomas in children and adults are a heterogeneous group of tumors that can be divided into at least three different subgroups: pediatric glioblastomas, IDH1-mutant glioblastomas in adults (the most favorable prognostic subtype), and IDH1-wild type glioblastomas in adults. According to the frequency of detected cytogenetic aberrations (amplification of the MYC/MYCN, EGFR and PDGRFA oncogenes, homozygous deletion of the CDKN2A gene, and deletion of the PTEN gene), pediatric glioblastomas bear analogy to the subgroup of IDH1-mutant glioblastomas in adults.

Keywords:

pediatric glioblastomas
IDH1-mutant glioblastomas in adults

Authors:

Ryzhova M.V.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

Shishkina L.V.

Burdenko Neurosurgery Institute, Moscow, Russia

Zheludkova O.G.

GU FNKTs detskoĭ gematologii, onkologii i immunologii Minzdrava RF im. D. Rogacheva, Moskva

Golanov A.V.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

Gorelyshev S.K.

GBU NII neĭrokhirurgii im. N.N. Burdenko

Pitskhelauri D.I.

Burdenko Neurosurgical Center

Bekiashev A.Kh.

FGBU "Rossiĭskiĭ nauchnyĭ onkologicheskiĭ tsentr im. N.N. Blokhina" RAMN, Moskva, Rossiia

Kobiakov G.L.

GBU NII neĭrokhirurgii im. N.N. Burdenko

Absaliamova O.V.

FGBU "Nauchno-issledovatel'skiĭ institut neĭrokhirurgii im. akad. N.N. Burdenko"

Sycheva R.V.

FGBU "Nauchno-issledovatel'skiĭ institut neĭrokhirurgii im. akad. N.N. Burdenko"

Korshunov A.G.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

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References:

  1. Antonelli M., Buttarelli F.R., Arcella A. et al. Prognostic significance of histological grading, p53 status, YKL-40 expression, and IDH1 mutations in pediatric high-grade gliomas. J Neurooncol 2010; 99: 209-215. DOI: 10.1007/s11060-010-0129-5
  2. Balss J., Meyer J., Mueller W. et al. Analysis of the IDH1 codon 132 mutation in brain tumors. Acta Neuropathol 2008. DOI: 10.1007/s00401-008-0455-2
  3. Byeon S.-J., Myung J.K., Kim S.H. et al. Distinct genetic alterations in pediatric glioblastomas. Childs Nerv Syst 2012; 28: 1025-1032. DOI: 10.1007/s00381-012-1773-1
  4. Capper D., Weiβert S., Balss J. et al. Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors. Brain Pathology 2010; 20: 245-254. DOI: 10.1111/j.1750-3639.2009.00352.x
  5. Capper D., Zentgraf H., Balss J. et al. Monoclonal antibody specific for IDH1 R132H mutation. Acta Neuropathol 2009; 118: 599-607.
  6. Carén H., Pollard S.M., Beck S. The good, the bad and the ugly: Epigenetic mechanisms in glioblastoma. Mol Aspects Med 2012. http://dx.doi.org/10.1016/j.mam.2012.06.007
  7. Deimling A., von Korshunov A., Hartmann C. The next generation of glioma biomarkers: MGMT methylation, BRAF fusions and IDH1 mutations. Brain Pathology 2011; 21: 74-87. DOI: 10.1111/j.1750-3639.2010.00454.x
  8. Dubuc A.M., Mack S., Unterberger A. et al. The epigenetics of brain tumors. Eds. R.G. Dumitrescu, M. Verma. Cancer epigenetics: methods and protocols, methods in molecular biology.Springer Science+Business Media LLC 2012; 863: 139-153. DOI: 10.1007/978-1-61779-612-8_8
  9. Garrett-Bakelman F.E., Melnick A.M. Differentiation therapy for IDH1/2 mutant malignancies. Cell Res 2013. DOI: 10.1038/cr.2013.73
  10. Hartmann C., Hentschel B., Wick W. et al. Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas. Acta Neuropathol 2010; 120: 707-718. DOI: 10.1007/s00401-010-0781-z.
  11. Je E.M., Yoo N.J., Lee S.H. Mutational analysis of H3F3A, a chromatin remodeling gene in common solid tumors. APMIS 2013. DOI: 10.1111/apm.12124
  12. Korshunov A., Sycheva R., Golanov A. Genetically distinct and clinically relevant subtypes of glioblastoma defined by array-based comparative genomic hybridization (array-CGH). Acta Neuropathol 2006; 111: 465-474. DOI: 10.1007/s00401-006-0057-9
  13. Korshunov A., Sycheva R., Golanov A. The prognostic relevance of molecular alterations in glioblastomas for patients age 50 years. Cancer 2005; 104: 825-832. DOI: 10.1002/cncr.21221
  14. Louis D.N., Ohgaki H., Wiestler O.D., Cavenee W.K. (Eds.): WHO Classification of Tumours of the Central Nervous System. IARC: Lyon 2007.
  15. Macy M.E., Birks D.K., Barton V.N. et al. Clinical and molecular characteristics of congenital glioblastoma. Neuro Oncol 2012; 14: 7: 931-941. DOI: 10.1093/neuonc/nos125
  16. Miller R., Perry A. Glioblastoma: morphologic and molecular genetic diversity. Arch Pathol Lab Med 2007; 131: 397-406.
  17. Ohgaki H., Kleihues P. Genetic alterations and signaling pathways in the evolution of gliomas. Cancer Sci 2009; 100: 2235-2241. DOI: 10.1111/ j.1349-7006.2009.01308.x
  18. Ohgaki H., Kleihues P. Genetic pathways to primary and secondary glioblastoma. Am J Pathol 2007; 170: 5: 1445-1453. DOI: 10.2353/ajpath. 2007.070011
  19. Ohgaki H., Kleihues P. The definition of primary and secondary glioblastoma. Clin Cancer Res 2012; 19: 4: 764-772. DOI: 10.1158/1078-0432.CCR-12-3002
  20. Parsons D.W., Jones S., Zhang X. et al. An integrated genomic analysis of human glioblastoma multiforme. Science 2008; 321: 1807-1812.
  21. Rickert C.H., Strater R., Kaatsch P. et al. Pediatric high-grade astrocytomas show chromosomal imbalances distinct from adult cases. Am J Pathol 2001; 158: 4: 1525-1532.
  22. Ruano Y., Ribalta T., Rodríguez de Lope A. et al. Worse outcome in primary glioblastoma multiforme with concurrent epidermal growth factor receptor and p53 alteration. Am J Clin Pathol 2009; 131: 257-263. DOI: 10.1309/AJCP64YBDVCTIRWV
  23. Schwartzentruber J., Korshunov A., Liu X.-Y. et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature 2012; 482: 226-231. DOI: 10.1038/nature10
  24. Sturm D., Witt H., Hovestadt V. et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell 2012; 22: 1-13. http://dx.doi.org/10.1016/j.ccr.2012.08.024
  25. Weiss M.M., Hermsen M.A.J.A., Meijer G.A. et al. Comparative genomic hybridization. J Clin Pathol Mol Pathol 1999; 52: 243-251.
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