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Ryzhova M.V.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

Kushel' Iu.V.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

Zheludkova O.G.

GU FNKTs detskoĭ gematologii, onkologii i immunologii Minzdrava RF im. D. Rogacheva, Moskva

Shishkina L.V.

Burdenko Neurosurgery Institute, Moscow, Russia

Panina T.N.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Melikian A.G.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

Zemlianskiĭ M.Iu.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN

Lemeneva N.V.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

Are the medulloepithelioma, ependymoblastoma and embryonal tumor with multilayered rosettes the same entity?

Authors:

Ryzhova M.V., Kushel' Iu.V., Zheludkova O.G., Shishkina L.V., Panina T.N., Melikian A.G., Zemlianskiĭ M.Iu., Lemeneva N.V.

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Journal: Burdenko's Journal of Neurosurgery. 2013;77(6): 51‑55

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ARE THE MEDULLOEPITHELIOMA, EPENDYMOBLASTOMA AND EMBRYONAL TUMOR WITH MULTILAYERED ROSETTES THE SAME ENTITY?
ARE THE MEDULLOEPITHELIOMA, EPENDYMOBLASTOMA AND EMBRYONAL TUMOR WITH MULTILAYERED ROSETTES THE SAME ENTITY?

To cite this article:

Ryzhova MV, Kushel' IuV, Zheludkova OG, et al. . Are the medulloepithelioma, ependymoblastoma and embryonal tumor with multilayered rosettes the same entity? Burdenko's Journal of Neurosurgery. 2013;77(6):51‑55. (In Russ., In Engl.)

Подписка 2025-2 (Burdenko's Journal of Neurosurgery)
 
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Medulloepithelioma is a rare malignant tumor arising in cerebral hemispheres. Microscopically, medulloepithelioma is characterized by epithelial structures that mimic the embryonic neural tube. Immunohistochemical analysis revealed that tumor cells are immunopositive for LIN28A and fluorescence in situ hybridization showed an amplification of a miRNA cluster at 19q13.42. Presence of these both aberrations suggesting that medulloepithelioma, ependymoblastoma and embryonal tumor with multilayered rosettes are the same entity.

Keywords:

medulloepithelioma
ependymoblastoma
embryonal tumor with multilayered rosettes
amplification miRNA at 19q13.42
LIN28A

Authors:

Ryzhova M.V.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

Kushel' Iu.V.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

Zheludkova O.G.

GU FNKTs detskoĭ gematologii, onkologii i immunologii Minzdrava RF im. D. Rogacheva, Moskva

Shishkina L.V.

Burdenko Neurosurgery Institute, Moscow, Russia

Panina T.N.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Melikian A.G.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

Zemlianskiĭ M.Iu.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN

Lemeneva N.V.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

List of references:

  1. Ryzhova M.V., Zheludkova O.G., Ozerov S.S., et al. A new entity in WHO classification of tumors of the central nervous system-embryonic tumor with abundant neuropile and true rosettes: case report and review of literature. Vopr Neirokhir 2011; 75 (4): 25—33. In Russian.
  2. Buccoliero A.M., Castiglione F., Degl’Innocenti D.R. et al. Embryonal tumor with abundant neuropil and true rosettes: morphological, immunohistochemical, ultrastructural and molecular study of a case showing features of medulloepithelioma and areas of mesenchymal and epithelial differentiation. Neuropathology 2010; 30: 84—91. doi:10.1111/j.1440-1789.2009. 01040.x
  3. Burger P.C., Scheithauer B.W., Kleinschmidt-DeMasters B.K. et al. Diagnostic Pathology. Neuropathology. Ed. P.C. Burger. 1-st Ed. Amirsys Salt Lake City (Utah) 2012.
  4. Burger P.C., Scheithauer B.W. Tumors of the Central Nervous System (AFIP atlas of tumor pathology, Series 4. Fascicle 7). Am Reg Pathol (Washington DC) 2007; 596; 14.
  5. Corrêa Z.M., Augsburger J.J., Spaulding A.G. Medulloepithelioma of the optic disc. Human Pathology 2011; 42: 2047—2051. doi:10.1016/j.humpath.2011.02.020
  6. Korshunov A., Remke M., Gessi M. et al. Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes . Acta Neuropathologica 2010; 120: 2: 253—260.
  7. Korshunov A., Ryzhova M., Jones D. T. W. et al. LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR). Acta Neuropathol 2012; 124: 875—881. doi:10.1007/s00401-012-1068-3
  8. Louis D.N., Ohgaki H., Wiestler O.D., Cavenee W.K. (Eds.). WHO Classification of Tumours of the Central Nervous System. IARC: Lyon 2007.
  9. McLendon R.E., Rosenblum M.K., Bigner D.D. Russell and Rubinstein’s Pathology of Tumors of the Nervous System. 7-th Ed. Hodder Arnold (London) 2006.
  10. Nobusawa S., Yokoo H., Hirato J. et al. Analysis of chromosome 19q13.42 amplification in embryonal brain tumors with ependymoblastic multilayered rosettes. Brain Pathol 2012; 22: 689—697. doi:10.1111/j.1750-3639.2012. 00574.x
  11. Pastora-Salvador N., Abelairas-Gómez J., Peralta-Calvo J. et al. Atypical clinical presentation and long-term survival in a patient with optic nerve medulloepithelioma: a case report. J Med Case Reports 2012; 6: 123. http://www.jmedicalcasereports.com/content/6/1/123
  12. Putnam A.R., Wallentine J.C., Polydorides A.D. et al. Diagnostic Pathology. Neuropathology. Eds. A.R. Putnam, J.C. Wallentine. 1-st Ed. Amirsys Salt Lake City (Utah) 2012.
  13. Syal R., Reddy J., Kumar R. et al. Unusual clinical and MRI features of a cerebellopontine angle medulloepithelioma: case report and review of literature. Pediatr Neurosurg 2006; 42: 299—303. doi:10.1159/000094066

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