Intraoperative fluorescent visualization and laser spectrosopy in intrinsic brain tumor surgery

Potapov A.A.; Gavrilov A.G.; Goriaĭnov S.A.; Gol'bin D.A.; Zelenkov P.V.; Kobiakov G.L.; Okhlopkov V.A.; Zhukov V.Iu.; Shishkina L.V.; Shurkhaĭ V.A.; Loshchenov V.B.; Savel'eva T.A.; Grachev P.V.; Kholodtsova M.N.; Kuz'min S.G.; Vorozhtsov G.N.

doi:https://doi.org/

Potapov A.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Gavrilov A.G.

N.N. Burdenko Institute of Neurosurgery, Moscow, Russia

Goriaĭnov S.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Gol'bin D.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Zelenkov P.V.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN

Kobiakov G.L.

GBU NII neĭrokhirurgii im. N.N. Burdenko

Okhlopkov V.A.

GBOU "Omskaia gosudarstvennaia meditsinskaia akademiia" Ministerstva zdravookhraneniia Rossiĭskoĭ Federatsii

Zhukov V.Iu.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN

Shishkina L.V.

Burdenko Neurosurgery Institute, Moscow, Russia

ORCID: 0000-0001-7045-7223

Shurkhaĭ V.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Loshchenov V.B.

Institut obshcheĭ fiziki im. A.M. Prokhorova RAN

Savel'eva T.A.

Institut obshcheĭ fiziki im. A.M. Prokhorova RAN

Grachev P.V.

Institut obshcheĭ fiziki im. A.M. Prokhorova RAN

Kholodtsova M.N.

Institut obshcheĭ fiziki im. A.M. Prokhorova RAN

Kuz'min S.G.

Research Institute of Clinical Oncology at N.N. Blokhin Oncological Research Centre

Vorozhtsov G.N.

'Intermedbiofizkhim' International Research and Clinical Centre, Moscow

Intraoperative fluorescent visualization and laser spectrosopy in intrinsic brain tumor surgery

Authors:

Potapov A.A., Gavrilov A.G., Goriaĭnov S.A., Gol'bin D.A., Zelenkov P.V., Kobiakov G.L., Okhlopkov V.A., Zhukov V.Iu., Shishkina L.V., Shurkhaĭ V.A., Loshchenov V.B., Savel'eva T.A., Grachev P.V., Kholodtsova M.N., Kuz'min S.G., Vorozhtsov G.N.

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Journal: Burdenko's Journal of Neurosurgery. 2012;76(5): 3‑12

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To cite this article:

Potapov AA, Gavrilov AG, Goriaĭnov SA, et al. Intraoperative fluorescent visualization and laser spectrosopy in intrinsic brain tumor surgery. Burdenko's Journal of Neurosurgery. 2012;76(5):3‑12. (In Russ.)

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)

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Abstract:

Absence of well-defined borders of the glial tumor due to their infiltrative growth is one of the main issues in neurosurgery. A number of methods for intraoperative visualization are available today. The fluorescent metabolic navigation with 5-aminolevulinic acid (5-ALA) combined with quantitative laser spectroscopy is one of the latest technique. In our series of 99 consecutive patients with brain gliomas (WHO Grade I-IV) we found that visible fluorescence was observed in 68% of cases. Additional use of the laser spectroscopy could increase method sensitivity up to 74% due to accumulation of the protoporphyrine IX in nonfluorescense tumors. It was shown that there are some differences in quantitative fluorescence not only within same tumor (glioblastoma) but also in-between low- and high-grade gliomas. Intraoperative fluorescence and laser spectroscopy are effective and very helpful methods of intraoperative imaging in of intrinsic brain tumor surgery.

Keywords:

glial brain tumors

metabolic navigation

5-aminolevulinic acid (5-ALA)

quantitative fluorescence

laser spectroscopy

Authors:

Potapov A.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Gavrilov A.G.

N.N. Burdenko Institute of Neurosurgery, Moscow, Russia

Goriaĭnov S.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Gol'bin D.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Zelenkov P.V.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN

Kobiakov G.L.

GBU NII neĭrokhirurgii im. N.N. Burdenko

Okhlopkov V.A.

GBOU "Omskaia gosudarstvennaia meditsinskaia akademiia" Ministerstva zdravookhraneniia Rossiĭskoĭ Federatsii

Zhukov V.Iu.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN

Shishkina L.V.

Burdenko Neurosurgery Institute, Moscow, Russia

ORCID: 0000-0001-7045-7223

Shurkhaĭ V.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Loshchenov V.B.

Institut obshcheĭ fiziki im. A.M. Prokhorova RAN

Savel'eva T.A.

Institut obshcheĭ fiziki im. A.M. Prokhorova RAN

Grachev P.V.

Institut obshcheĭ fiziki im. A.M. Prokhorova RAN

Kholodtsova M.N.

Institut obshcheĭ fiziki im. A.M. Prokhorova RAN

Kuz'min S.G.

Research Institute of Clinical Oncology at N.N. Blokhin Oncological Research Centre

Vorozhtsov G.N.

'Intermedbiofizkhim' International Research and Clinical Centre, Moscow

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