Objective. To assess an alliance-centred method of short-term psychotherapy (AP) in the formation of compliance in patients with opiate addiction. Material and methods. Authors studied 100 male inpatients with ICD-10 diagnosis Opioid Dependence (F11.2). Patients were stratified into main (with use of AP) and control groups. The tasks of short-term psychotherapy were to determine mutual goals for the patient and the physician and the interaction between them. Results and Conclusion. Based on some special quantitative psychological tests and correlation analysis, it was identified that AP stimulated compliance behaviour in patients with opioid dependence more effectively than traditional recommendations